A5083297397- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Advanced Neuroimaging Techniques and Applications
- Management of metastatic bone disease
- Traumatic Brain Injury Research
- Breast Cancer Treatment Studies
- Cardiac pacing and defibrillation studies
- Lung Cancer Research Studies
- MRI in cancer diagnosis
- Atrial Fibrillation Management and Outcomes
- Brain Tumor Detection and Classification
- Traumatic Brain Injury and Neurovascular Disturbances
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Effects of Radiation Exposure
- Head and Neck Cancer Studies
University Hospital of Zurich
2019-2025
University of Zurich
2019-2024
Klinikum rechts der Isar
2017-2024
Technical University of Munich
2018-2024
The Netherlands Cancer Institute
2020
Nestlé (France)
2020
Universitätsklinik für Strahlentherapie
2020
European Institute of Oncology
2018
Ludwig-Maximilians-Universität München
2014-2017
Brigham and Women's Hospital
2014-2017
Soccer is played by more than 250 million people worldwide. Repeatedly heading the ball may place soccer players at high risk for repetitive subconcussive head impacts (RSHI). This study evaluates long-term effects of RSHI on neurochemistry in athletes without a history clinically diagnosed concussion, but with exposure to RSHI. Eleven former professional (mean age 52.0±6.8 years) and comparison cohort 14 age- gender-matched, non-contact sport 46.9±7.9 underwent 3T magnetic resonance...
The interindividual differences in severity of acute radiation dermatitis are not well understood. To date, the pathomechanism and interplay microbiome radiodermatitis before during treatment remain largely unknown.
Concussion is a common injury in ice hockey and health problem for the general population. Traumatic axonal has been associated with concussions (also referred to as mild traumatic brain injuries), yet pathological course that leads from recovery or long-term sequelae still not known. This study investigated longitudinal of concussion by comparing diffusion MRI (dMRI) scans brains players before after concussion.The 2011-2012 Hockey Education Project followed 45 university-level (both male...
Object The aim of this study was to examine the brain's white matter microstructure by using MR diffusion tensor imaging (DTI) in ice hockey players with a history clinically symptomatic concussion compared without concussion. Methods Sixteen (concussed group; mean age 21.7 ± 1.5 years; 6 female) and 18 (nonconcussed 21.3 1.8 years, 10 underwent 3-T DTI at end 2011–2012 Canadian Interuniversity Sports season. Tract-based spatial statistics (TBSS) used test for group differences fractional...
Worldwide, more than 22 million children and adolescents are exposed to repetitive head impacts (RHI) in soccer. Evidence indicates cumulative effects on brain structure, but it is not known whether exposure RHI affects cognitive improvement adolescents. The aim of the study was determine while heading ball soccer performance over time. group consisted a convenience sample 16 male players (mean age 15.7 ± 0.7 years). A comparison cohort 14 non-contact sports athletes 14.9 1.1 years)...
To explore the prognostic value of oligometastatic disease (OMD) states as proposed by European Society for Radiotherapy and Oncology (ESTRO) Organisation Research Treatment Cancer (EORTC) classification system.This retrospective single-institution study included patients with 1-5 extracranial metastases from any solid malignancy treated SBRT to all metastases. OMD were defined according ESTRO EORTC classification. Overall survival (OS) progression-free (PFS) analyzed using Kaplan-Meier...
Concussion, or mild traumatic brain injury (mTBI), is a commonly occurring sports-related injury, especially in contact sports such as hockey. Cerebral microbleeds (CMBs), which appear small, hypointense lesions on T₂*-weighted images, can result from TBI. The authors use susceptibility-weighted imaging (SWI) to automatically detect small hypointensities that may be subtle signs of chronic and acute damage due both subconcussive concussive injury. goal was investigate how the burden these...
Abstract Purpose To assess the effects of daily adaptive MR-guided replanning in stereotactic body radiation therapy (SBRT) liver metastases based on a patient individual longitudinal dosimetric analysis. Methods Fifteen patients assigned to SBRT for oligometastatic underwent target localization and on-table treatment plan re-optimization. Gross tumor volume (GTV) organs at risk (OARs) were adapted anatomy-of-the-day. A reoptimized (RP) rigidly shifted baseline (sBP) without re-optimization...
Radiomics offers great potential in improving diagnosis and treatment for patients with glioblastoma multiforme. However, order to implement radiomics clinical routine, the features used prognostic modelling need be stable. This comprises significant challenge multi-center studies. The aim of this study was evaluate impact different image normalization methods on MRI robustness study.Radiomics stability checked magnetic resonance images eleven patients. were acquired two hospitals using...
Abstract Aims Stereotactic arrhythmia radioablation (STAR) has been recently introduced for the management of therapy-refractory ventricular tachycardia (VT). VT recurrences have reported after STAR but mechanisms remain largely unknown. We analysed in our patients STAR. Methods and results From 09.2017 to 01.2020, 20 (68 ± 8 y, LVEF 37 15%) suffering from refractory were enrolled, 16/20 with a history at least one electrical storm. Before STAR, an invasive electroanatomical mapping (Carto3)...
Abstract Background Surgical resection is the standard of care for patients with large or symptomatic brain metastases (BMs). Despite improved local control after adjuvant stereotactic radiotherapy, risk failure (LF) persists. Therefore, we aimed to develop and externally validate a pre-therapeutic radiomics-based prediction tool identify at high LF risk. Methods Data were collected from A Multicenter Analysis Stereotactic Radiotherapy Resection Cavity BMs (AURORA) retrospective study...
This study was performed to evaluate skin toxicity during modern three-dimensional conformal radiotherapy (3D-CRT) and the importance of dose distribution patient related factors.This comprises 255 patients with breast cancer treated tangential after conserving surgery between 03/2012 05/2017. The median prescribed 50.4 Gy (range 50-50.4) 92.2% received a sequential boost 10-16 Gy. Adverse toxicities (according CTCAE v. 4.03 occurrence moist desquamations) were assessed at end treatment. in...
Abstract Background Careful selection of malignant pleural mesothelioma (MPM) patients for curative treatment is highest importance, as the multimodal regimen challenging and harbors a high risk substantial toxicity. Radiomics—a quantitative method image analysis—has shown its prognostic ability in different tumor entities could therefore play an important role optimizing patient radical cancer treatment. So far, radiomics tool MPM was not investigated. Materials methods This study based on...
Stereotactic radiotherapy is a standard treatment option for patients with brain metastases. The planning target volume based on gross tumor (GTV) segmentation. aim of this work to develop and validate neural network automatic GTV segmentation accelerate clinical daily routine practice minimize interobserver variability.We analyzed MRIs (T1-weighted sequence ± contrast-enhancement, T2-weighted sequence, FLAIR sequence) from 348 at least one metastasis different cancer primaries treated in...
A novel quality assurance process for electroanatomical mapping (EAM)-to-radiotherapy planning imaging (RTPI) target transport was assessed within the multi-center multi-platform framework of RAdiosurgery VENtricular TAchycardia (RAVENTA) trial. stand-alone software (CARDIO-RT) developed to enable platform independent registration EAM and RTPI left ventricle (LV), based on pre-generated radiotherapy contours (RTC). LV-RTC were automatically segmented into American-Heart-Association...