Fırat Duru
A5047983323- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Sports injuries and prevention
- Atrial Fibrillation Management and Outcomes
- Cardiomyopathy and Myosin Studies
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Particle Detector Development and Performance
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Advanced MRI Techniques and Applications
- Viral Infections and Immunology Research
- Dark Matter and Cosmic Phenomena
- Cardiovascular Syncope and Autonomic Disorders
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular and exercise physiology
- COVID-19 Clinical Research Studies
University Hospital of Zurich
2016-2025
University of Zurich
2016-2025
Swiss Integrative Center for Human Health
2015-2024
Zurich Heart House
2015-2024
GZO Spital Wetzikon
2022-2024
Fu Wai Hospital
2019-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
University Medical Centre Mannheim
2022
Nestlé (France)
2020
Coe College
2016-2020
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients.Five hundred twenty-eight patients with definite diagnosis no history sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries North America Europe. Over 4.83 (interquartile range 2.44-9.33) years follow-up, 146 (27.7%)...
Abstract Aims Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is characterized by arrhythmias (VAs) and sudden cardiac death (SCD). We aimed to develop a model for individualized prediction of incident VA/SCD in ARVC patients. Methods results Five hundred twenty-eight patients with definite diagnosis no history sustained VAs/SCD at baseline, aged 38.2 ± 15.5 years, 44.7% male, were enrolled from five registries North America Europe. Over 4.83 (interquartile range 2.44–9.33)...
Pathogenic desmoplakin (DSP) gene variants are associated with the development of a distinct form arrhythmogenic cardiomyopathy known as DSP cardiomyopathy. Patients harbouring these at high risk for sustained ventricular arrhythmia (VA), but existing tools individualized arrhythmic assessment have proven unreliable in this population.
Aims Magnetic resonance imaging (MRI) is well established as an important diagnostic tool in medicine.However, the presence of a cardiac pacemaker usually regarded contraindication for MRI due to safety reasons.In this study, heating effects at myocardium-pacemaker lead tip interface have been investigated chronic animal model during 1.5 Tesla. Methods and resultsPacemaker leads with additional thermocouple wires temperature sensors were implanted nine animals.Temperature increases up 208C...
Short QT syndrome (SQTS) is a genetically determined ion-channel disorder, which may cause malignant tachyarrhythmias and sudden cardiac death. Thus far, mutations in five different genes encoding potassium calcium channel subunits have been reported. We present, for the first time, novel loss-of-function mutation coding an L-type subunit. The electrocardiogram of affected member single family revealed interval 317 ms (QTc 329 ms) with tall, narrow, symmetrical T-waves. Invasive...
Background ECG criteria differentiating Takotsubo cardiomyopathy (TTC) from mainly anterior myocardial infarction (MI) have been suggested; however, this was in small patient populations. Methods and Results Twelve‐lead admission ECGs of consecutive 200 TTC MI patients were compared dichotomized groups based on the presence or absence ST‐elevation (STEMI versus STE‐TTC non‐ST elevation non ST‐elevation‐TTC). When comparing STEMI STE‐TTC, –aVR characteristic with a sensitivity/specificity 43%...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by myocardial replacement and life-threatening arrhythmias. Desmosomal gene mutations are sometimes identified, but clinical genetic diagnosis remains challenging. skin disorders can be caused desmosomal or autoantibodies. We sought to determine if anti-desmosome antibodies present in subjects with ARVC.
Aims Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is characterized by fibrofatty infiltration of the myocardium and arrhythmias that may lead to sudden cardiac death. It has been observed male patients develop disease earlier present with more severe phenotypes as compared females. Thus, we hypothesized serum levels sex hormones contribute major arrhythmic cardiovascular events (MACE) in ARVC/D. Methods results The five hormones, hormone-binding globulin, high...
The value of standard 2-dimensional transthoracic echocardiographic parameters for risk stratification in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is controversial.We investigated the impact RV fractional area change (FAC) and tricuspid annulus plane systolic excursion (TAPSE) prediction major adverse cardiovascular events (MACE) defined as occurrence cardiac death, heart transplantation, survived sudden fibrillation, sustained tachycardia, or syncope....
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with arrhythmias (VA) and sudden cardiac death (SCD). A model was recently developed to predict incident sustained VA in patients ARVC. However, since this outcome may overestimate the risk for SCD, we aimed specifically life-threatening (LTVA) as a closer surrogate SCD.We assembled retrospective cohort of definite ARVC cases from 15 centers North America Europe. Association 8 prespecified clinical predictors LTVA (SCD,...
Patients with likely pathogenic/pathogenic desmoplakin (
Abstract Background and Aims Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences utilization of primary prevention ICDs survival free from sustained arrhythmia (VA) ARVC. Methods was a retrospective analysis ARVC patients without prior VA enrolled clinical registries 11 countries throughout Europe North America. Patients were...
Abstract Background and Aims Pathogenic variants in the desmoplakin (DSP) gene are associated with development of a distinct arrhythmogenic cardiomyopathy phenotype not fully captured by either dilated (DCM), non-dilated left ventricular (NDLVC), or right (ARVC). Prior studies have described baseline DSP genetic, inflammatory, structural characteristics. However, cohort sizes limited full clinical characterization identification demographic predictors sustained arrhythmias (VAs), heart...
BACKGROUND: Genetic variants in desmosomal cadherins, desmoglein 2 ( DSG2 ) and desmocollin DSC2 ), cause a distinct form of arrhythmogenic right ventricular cardiomyopathy (ARVC), which remains poorly reported. In this study, we aimed to provide comprehensive description the phenotypic expression, natural history, clinical outcomes patients with ARVC subset. METHODS: data variant carriers were collected from 5 countries Europe Asia. We assessed profile these their outcomes, focusing on...
LUECHINGER, R., et al. : Force and Torque Effects of a 1.5‐Tesla MRI Scanner on Cardiac Pacemakers ICDs. Magnetic resonance imaging (MRI) is widely accepted tool for the diagnosis variety disease states. However, presence an implanted pacemaker considered to be strict contraindication in vast majority centers due safety concerns. In phantom studies, authors investigated force torque effects static magnetic field pacemakers Thirty‐one (15 dual chamber 16 single units) from eight manufacturers...