A5029485255- Cardiovascular Effects of Exercise
- Sports injuries and prevention
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Gun Ownership and Violence Research
- Cardiac Structural Anomalies and Repair
- Genetics and Physical Performance
- Vector-Borne Animal Diseases
- Cardiac Arrest and Resuscitation
- Cardiovascular and exercise physiology
- Cardiovascular Issues in Pregnancy
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Restraint-Related Deaths
- Retinal Development and Disorders
- Histiocytic Disorders and Treatments
- RNA regulation and disease
- Sports Performance and Training
- Eosinophilic Disorders and Syndromes
- Cellular transport and secretion
- Congenital Heart Disease Studies
- Skin and Cellular Biology Research
- Electrostatic Discharge in Electronics
Onassis Cardiac Surgery Center
2021-2025
National and Kapodistrian University of Athens
2001-2023
Aristotle University of Thessaloniki
2023
Harvard University
2011-2016
Johns Hopkins University
2010-2016
Beth Israel Deaconess Medical Center
2011-2016
Marienhospital Osnabrück
2015
University of Pennsylvania Health System
2015
Tufts University
2015
Netherlands Heart Institute
2015
Background— In 1994, an International Task Force proposed criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) that facilitated recognition and interpretation frequently nonspecific features ARVC/D. This enabled confirmatory in index cases through exclusion phenocopies provided a standard on which research genetic studies could be based. Structural, histological, electrocardiographic, arrhythmic, familial disease were incorporated into...
In 1994, an International Task Force proposed criteria for the clinical diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) that facilitated recognition and interpretation frequently nonspecific features ARVC/D. This enabled confirmatory in index cases through exclusion phenocopies provided a standard on which research genetic studies could be based. Structural, histological, electrocardiographic, arrhythmic, familial disease were incorporated into criteria,...
The diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) can be challenging because the clinical presentation is highly variable and genetic penetrance often low.To determine whether a change in distribution desmosomal proteins used as sensitive specific diagnostic test for ARVC, we performed immunohistochemical analysis human myocardial samples.We first tested myocardium from 11 subjects with ARVC; these samples, 8 had gene mutations. We also obtained at autopsy 10 no or...
Abstract Aims To study the impact of genotype on performance 2019 risk model for arrhythmogenic right ventricular cardiomyopathy (ARVC). Methods and results The cohort comprised 554 patients with a definite diagnosis ARVC no history sustained arrhythmia (VA). During median follow-up 6.0 (3.1,12.5) years, 100 (18%) experienced primary VA outcome (sustained tachycardia, appropriate implantable cardioverter defibrillator intervention, aborted sudden cardiac arrest, or death) corresponding to an...
Cardiac abnormalities were identified in patients with familial palmoplantar keratosis. All of them descended from families on the Greek island Naxos. Four studied and nine cases keratosis identified; seven showed symptoms signs heart disease. Cardiomegaly chest x ray electrocardiographic common findings. Three had episodes ventricular tachycardia a fourth patient died suddenly. cardiac echocardiographic enlargement right ventricle band; three left was also affected.
Background —Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disease of unknown etiology that causes arrhythmias, failure, and sudden death. Diagnosis can be difficult, this hampers investigation its molecular basis. Forms ARVC in which gene penetrance expression are greater should facilitate genetic study. We undertook clinical Naxos disease, originally described by Protonotarios 1986. This constitutes the triad ARVC, diffuse nonepidermolytic palmoplantar...
Background— Immunoreactive signal for the desmosomal protein plakoglobin (γ-catenin) is reduced at cardiac intercalated disks in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), a highly condition caused by mutations genes encoding proteins. Previously, we observed false-positive case which was patient initially believed to have ARVC but who actually had sarcoidosis. Sarcoidosis can masquerade clinically as has not been previously associated altered Methods and Results—...
To evaluate arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) in affected families with desmosome mutations on the basis of recently revised Task Force Criteria (TFC). One hundred and three consecutive carriers pathogenic 102 mutation-negative relatives belonging to 22 dominant 14 recessive ARVC/D were evaluated according original TFC. Serial cardiac assessment 12-lead, signal-averaged, 24 h ambulatory ECG two-dimensional echocardiography was performed. Clinical events...
AimsArrhythmogenic right-ventricular cardiomyopathy (ARVC) is a genetically determined disorder, mostly caused by mutations in genes encoding desmosomal proteins. We evaluated phenotype/genotype characteristics to predict the risk for first major arrhythmic event desmosomal-mutation-associated ARVC families.
Analysis of myocardium has revealed mechanistic insights into arrhythmogenic cardiomyopathy but cardiac samples are difficult to obtain from probands and especially family members. To identify a potential surrogate tissue, we characterized buccal mucosa cells.Buccal cells patients, mutation carriers, controls were immunostained analyzed in blinded fashion. In additional studies, grown vitro incubated with SB216763. Immunoreactive signals for the desmosomal protein plakoglobin major gap...
AimsRecent immunohistochemical studies observed the loss of plakoglobin (PG) from intercalated disc (ID) as a hallmark arrhythmogenic right ventricular cardiomyopathy (ARVC), suggesting final common pathway for this disease. However, underlying molecular processes are poorly understood.
Abstract The presence of multiple pathogenic variants in desmosomal genes ( DSC2 , DSG2 DSP JUP and PKP2 ) patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) has been linked to a severe phenotype. However, the pathogenicity is reclassified frequently, which may result changed clinical risk prediction. Here, we present collection, reclassification, outcome correlation for largest series ARVC carrying date n = 331). After only 29% remained carriers two (likely) variants. They...