A5067217739- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Cardiovascular and Diving-Related Complications
- Electrostatic Discharge in Electronics
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Public Administration and Political Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Valve Diseases and Treatments
- Pancreatic function and diabetes
- 14-3-3 protein interactions
- Atomic and Subatomic Physics Research
- Prion Diseases and Protein Misfolding
- Plasma Applications and Diagnostics
- Hemodynamic Monitoring and Therapy
- Combustion and Detonation Processes
- Acute Myocardial Infarction Research
- Metabolism, Diabetes, and Cancer
- Microbial metabolism and enzyme function
University Medical Center Hamburg-Eppendorf
2021-2025
German Centre for Cardiovascular Research
2022-2025
Universität Hamburg
2021-2025
Asklepios Klinik St. Georg
2025
University Hospital Münster
2019-2024
University Cancer Center Hamburg
2024
RELX Group (United States)
2024
RELX Group (United Kingdom)
2024
Sorbonne Université
2024
University of Birmingham
2020-2021
Abstract Purpose Pulsed-field ablation (PFA) is a new energy source to achieve pulmonary vein isolation (PVI) by targeted electroporation of cardiomyocytes. Experimental and controlled clinical trial data suggest good efficacy PFA-based PVI. We aimed assess efficacy, safety follow-up PVI in an early adopter routine care setting. Methods Consecutive patients with symptomatic paroxysmal or persistent atrial fibrillation (AF) underwent using the Farawave® PFA catheter conjunction...
Abstract Background and Aims In patients with atrial fibrillation (AF), recurrent AF sinus rhythm during follow-up are determined by interactions between cardiovascular disease processes control therapy. Predictors of attaining at not well known. Methods To quantify the interaction outcomes, 14 biomarkers reflecting AF-related in 1586 EAST-AFNET 4 biomolecule study (71 years old, 45% women) were quantified baseline. Mixed logistic regression models including clinical features constructed for...
Hyperglycaemia-induced oxidative stress and inflammation contribute to vascular cell dysfunction subsequent cardiovascular events in T2DM. Selective sodium-glucose co-transporter-2 (SGLT-2) inhibitor empagliflozin significantly improves mortality T2DM patients (EMPA-REG trial). Since SGLT-2 is known be expressed on cells other than the kidney cells, we investigated potential ability of regulate glucose transport alleviate hyperglycaemia-induced these cells.Primary human monocytes were...
Abstract Aims Pulsed-field ablation (PFA) is an emerging technology to perform pulmonary vein isolation (PVI). Initial data demonstrated high safety and efficacy. Data on long-term PVI durability reconduction patterns in comparison established energy sources for are scarce. We compare findings repeat procedures after a first PFA cryoballoon (CBA) based PVI. Methods result A total of 550 consecutively enrolled patients underwent or CBA index Repeat ablations with symptomatic atrial arrhythmia...
Abstract Aims A novel three-dimensional mapping platform combined with a lattice-tip catheter that can toggle between monopolar pulsed field ablation (PFA) and radiofrequency energy delivery was recently launched. So far, the system predominantly applied in general anaesthesia (GA), not deep sedation. Methods results Patients symptomatic paroxysmal or persistent atrial fibrillation (AF) were enrolled, pulmonary vein isolation (PVI) of additional linear lesion sets performed either GA Pulsed...
Pulsed-field ablation (PFA) and the multielectrode radiofrequency balloon (RFB) are two novel technologies to perform pulmonary vein isolation (PVI). It is currently unknown whether these differ in lesion formation extent. We compared acute extent after PVI induced by PFA RFB measuring low-voltage area high-density maps release of biomolecules reflecting cardiac injury.PVI was performed with a pentaspline catheter (FARAPULSE) applying or compliant (HELIOSTAR). Before mapping CARTO 3...
Abstract Background High-sensitivity cardiac troponin (hs-cTn) assays indicating myocardial injury are critical for the diagnosis of acute infarction (AMI), but their use to differentiate between and chronic is limited. This study aimed assess differential utility three hs-cTn assays, targeting different epitopes (proximal and/or central), detect in a clinical model by left-atrial ablation. Methods First, pre- post-procedural serum samples were prospectively collected from 158 patients...
Simplified detection of atrial arrhythmias via consumer-electronics would enable earlier therapy in at-risk populations. Whether this is feasible and effective older populations not known.The fully remote, investigator-initiated Smartphone wearable detected arrhythmia Older Adults Case finding study (Smart OAC-AFNET 9) digitally enrolled participants ≥65 years without known fibrillation, receiving oral anticoagulation Germany, Poland, Spain for 8 weeks. Participants were invited by media...
Achieving early rhythm control and maintaining sinus are associated with improved outcomes in patients atrial fibrillation (AF). Pulmonary vein isolation (PVI) is a validated alternative to medical control. This study determined associations between left strain reservoir (LAS
Genetically altered mice are powerful models to investigate mechanisms of atrial arrhythmias, but normal ranges for murine electrophysiology have not been robustly characterized.We analyzed results from 221 electrophysiological (EP) studies in isolated, Langendorff-perfused hearts wildtype (114 female, 107 male) 2.5 17.7 months (mean 7 months) with different genetic backgrounds (C57BL/6, FVB/N, MF1, 129/Sv, Swiss agouti). Left monophasic action potential duration (LA-APD), interatrial...
ulsed field ablation (PFA) is rapidly gaining importance in the of pulmonary vein isolation (PVI). 1 Initial data using PFA-capable multispline catheters suggests that PFA effective and safe for PVI. 2,3However, lack ability delivering individualized, focal lesions with different energy levels.Recently, a novel system (CENTAURI; Galvanize Therapeutics) was introduced enables monopolar biphasic commercially available, contact forcesensing, solid-tip their associated 3-dimensional mapping...
A novel multielectrode radiofrequency balloon (RFB) catheter has been released for pulmonary vein isolation (PVI).
Objective: This work proposes a semi-supervised training approach for detecting lung and heart sounds simultaneously with only one trained model in invariance to the auscultation point. Methods: We use open-access data from 2016 Physionet/CinC Challenge, 2022 George Moody sound database HF_V1. first train specialist single-task models using foreground ground truth (GT) labels different databases identify background events respective databases. The pseudo-labels generated this way were...
Cryoballoon (CB)- based pulmonary vein isolation (PVI) remains guided by fluoroscopy and dye. The novel saline injection-based occlusion tool allows for (PV)-occlusion assessment without the need dye injection.To compare KODEX-EPD CB-PVI using workflow with conventional cryoablation acute efficacy, exposure volume.Consecutive atrial fibrillation (AF)- patients undergoing in conjunction (CryoEPD group) were analyzed. Patients (Cryo same time period acted as controls.One hundred forty [91/140...
To investigate the feasibility, acute efficacy, periprocedural safety, and procedural parameters of CB-based PVI guided by KODEX-EPD using different occlusion tool software versions.A total 173 patients (60/173 (35%) paroxysmal AF, 64 ± 12 years, 66/173 (38%) female), underwent between August 2019 October 2021. Acute was achieved in all patients. Total fluoroscopy time dye volume were 13.9 [10.6-19.4] min 47.5 [20-70] ml. Periprocedural complications occurred 3 (2%) As part continued...
ABSTRACT Sporadic Creutzfeldt-Jakob disease is the predominant type of human prion disease. While routine diagnostic in phenotypic cases has advanced considerably, clinical heterogeneity and rarity subtypes continue to constitute a major challenge. Here, we report peculiar case Heidenhain-variant MM1 sporadic presenting as stroke mimic an 81-year-old patient with rapid clinically distinct course compared previously reported cases. 14-3-3 protein was negative, findings substantiated by...
Abstract Background Although electrophysiological (EP) centers have institutional standards, evidence on management of cardiac tamponade is lacking. Aim and Methods A physician‐based survey was conducted by sending out questionnaires to all hospitals in Germany performing EP procedures. To evaluate the infrastructure impact center volume onsite surgery tamponade, results were analyzed for low‐volume (0–250 procedures per year), mid‐volume (250–500 procedures), high‐volume (>500...
Introduction: Recent studies implicate a positive effect of empagliflozin, selective sodium-glucose co-transporter-2 (SGLT-2) inhibitor, on cardiovascular mortality in Type 2 Diabetes mellitus (T2DM) patients. Since SGLT-2 is expressed monocytes and endothelial cells (EC) dysfunction those T2DM known, we investigated the potential ability empagliflozin to regulate glucose transport alleviate HG-induced these cells.