A5103163186- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac Valve Diseases and Treatments
- Cardiac pacing and defibrillation studies
- Clinical practice guidelines implementation
- MicroRNA in disease regulation
- Traumatic Brain Injury and Neurovascular Disturbances
- Palliative Care and End-of-Life Issues
- COVID-19 and healthcare impacts
- Acute Myocardial Infarction Research
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Cardiac Arrhythmias and Treatments
- Erythropoietin and Anemia Treatment
- Cardiac Imaging and Diagnostics
- Iron Metabolism and Disorders
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cytokine Signaling Pathways and Interactions
- Protein Kinase Regulation and GTPase Signaling
- Emergency and Acute Care Studies
- Heart Failure Treatment and Management
Philipps University of Marburg
2016-2025
Universitätsklinikum Gießen und Marburg
2013-2023
Philips (Germany)
2023
Philips (United States)
2017
Medizinische Hochschule Hannover
1998-2012
University of Freiburg
1991-1997
Emory University
1995-1996
In vascular smooth muscle cells, the induction of early growth response genes involves Janus kinase (JAK)/signal transducer and activators transcription (STAT) Ras/Raf-1/mitogen-activated protein cascades. present study, we found that electroporation antibodies against MEK1 or ERK1 abolished cell proliferation in to either platelet-derived factor angiotensin II. However, anti-STAT1 -STAT3 antibody proliferative responses only II not factor. AG-490, a specific inhibitor JAK2 tyrosine kinase,...
MicroRNA (miR) is reported to be involved in vascular inflammation and may represent a novel class of diagnostic biomarkers cardiovascular disease. We aimed identify the miR expression profile human advanced coronary atherosclerotic plaques (CAP) connect this processes atherosclerosis. Microarray techniques TaqMan polymerase chain reaction were used analyse global 352 miRs CAP obtained during ACS MULTI-LINK study. 11 selected on basis their implication atherosclerosis, endothelial...
An early event in signaling by the G-protein-coupled angiotensin II (Ang II) AT<sub>1</sub>receptor vascular smooth muscle cells is tyrosine phosphorylation and activation of phospholipase Cγ1 (PLCγ1). In present study, we show that stimulation this Ang accompanied binding PLCγ1 to AT<sub>1</sub> receptor an II- phophorylation-dependent manner. The PLCγ1-AT<sub>1</sub> interaction appears depend on 319 a YIPP motif C-terminal intracellular domain phosphorylated most two Src homology 2...
The proinflammatory alarmins S100A8 and S100A9 are among the most abundant proteins in neutrophils monocytes but completely silenced after differentiation to macrophages. molecular mechanisms of extraordinarily dynamic transcriptional regulation S100a8 S100a9 genes, however, only barely understood. Using an unbiased genome-wide CRISPR/Cas9 knockout (KO)-based screening approach immortalized murine monocytes, we identified transcription factor C/EBPδ as a central regulator expression. We...
Background: Transcatheter aortic valve replacement (TAVR) is the standard treatment for stenosis (AS), particularly in elderly or high-risk surgical patients. The New York Heart Association (NYHA) classification, which assesses severity of heart failure (HF), a key factor influencing TAVR outcomes. However, its impact on procedural success, complications, and outcomes remains underrepresented recent studies. Methods: In this multicenter study, data from 2,256 patients who underwent between...
Abstract Background Despite continuous advances in post-resuscitation management, the outcome after out-of-hospital cardiac arrest (OHCA) is limited. To improve outcome, interdisciplinary centres (CACs) have been established recent years, but survival remains low, and treatment strategies vary considerably clinical geographical aspects. Here we analysed a strategy of in-hospital management while evaluating outcome. Methods A broad spectrum pre- parameters 545 resuscitated patients admitted...
Background: The L-type calcium channel (LCC) plays a crucial role in the electrical remodeling of atrial fibrillation (AF). AF is associated with reduction current density, due to transcriptional downregulation pore forming alpha1c-subunit LCC. However, it unclear, whether this related decrease number or alterations function. Hence, we performed single LCC analysis assess gating and function human AF. Methods results: We used cell-attached patch-clamp technique isolated cardiomyocytes 25...
OBJECTIVES: Early mechanical circulatory support with Impella may improve survival outcomes in the setting of postcardiac arrest cardiogenic shock after out-of-hospital cardiac complicating acute myocardial infarction. However, optimal timing to initiate this particular remains unclear. Therefore, we aimed compare patients supported 2.5 before percutaneous coronary intervention (pre-PCI) those (post-PCI). DESIGN: Retrospective single-center study between September 2014 and December 2019...
MicroRNA has been increasingly suggested to be involved in vascular inflammation. The aim of this study was assess the expression profile miRs as possible novel cellular biomarkers circulating monocytes patients with ST-segment elevation myocardial infarction (STEMI). Microarray techniques and TaqMan polymerase chain reaction were used analyse global 352 miRNAs peripheral blood from healthy donors (n = 20) 24) acute STEMI. level miR-143 STEMI compared controls increased, whereas miR-1, -92a,...
To evaluate the effects of left ventricular support with microaxial pump using Impella device on renal resistive index assessed by Doppler ultrasonography in haemodynamically stable patients cardiogenic shock following myocardial infarction.A non-randomised interventional single-centre study. Consecutive supported an were included during May 2018 and October 2018. The determined as a quotient (peak systolic velocity - end diastolic velocity)/ peak was obtained ultrasound; invasive blood...
Albuminuria has emerged from being a sign of early kidney disease in diabetes to an independent predictor cardiovascular risk. Epidemiological studies suggest that microalbuminuria (30-300 mg/d) is present 5-19% the general population, up 23% patients with hypertension and 40% diabetes. Recent data even higher prevalence certain patient populations. As it associated variety important risk factors, including prediabetes, dyslipidemia metabolic syndrome, detection albumin urine represents...
Objectives. Studies have evaluated the association of galectin-3 and outcome in patients with heart failure. However, there is still scarce evidence concerning clinical usefulness predictive value for left ventricular reverse remodeling (LVRR) recent-onset dilated cardiomyopathy (RODCM). Patients Methods. Baseline was measured 57 RODCM. All were followed at least 12 months. The study end point LVRR months, defined as an absolute improvement ejection fraction ≥10% to a final ≥35%, accompanied...
Background The Home Monitoring (HM) system of cardiac implantable electronic devices (CIEDs) permits early detection arrhythmias or device failures. aim this pilot study was to examine how the safety and efficacy HM in patients after ambulatory implanted primary CIEDs compare with a standard procedure hospitalization. Hypothesis We hypothesized that their modifications would be useful extension present concepts for CIEDs. Methods This retrospective analysis evaluates telemetric data obtained...
Einleitung Die COVID-19-Pandemie bedeutet einschneidende Maßnahmen für das nationale Gesundheitssystem. Dies bot den Anlass, die klinischen und ökonomischen Leistungsindikatoren der gynäkologischen geburtshilflichen Versorgung des Universitätsklinikums Marburg als regionaler universitärer Maximalversorger zu analysieren. Hierzu wurden Auswirkungen auf monatlichen stationären ambulanten Fallzahlvolumina sowie entsprechenden ICD- DRG-Kodierungen ausgewertet, um etwaige Versorgungsdefizite...
Familial hypercholesterolemia (FH) is an autosomal dominant lipid metabolism disorder characterized by severely elevated plasma low-density lipoprotein cholesterol levels. The disease caused mutations in 3 genes ( LDLR , APOB and PCSK9 ) while over 90% of the are located within gene. Thus, genetic analysis gene first step diagnosis FH. However, conventional methods like Sanger NextGen sequencing still costly time-consuming. In contrast, Oxford Nanopore technology emerging third-generation...