A5067527456- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- Spectroscopy and Quantum Chemical Studies
- Cardiovascular Function and Risk Factors
- Acute Kidney Injury Research
- Cardiac Ischemia and Reperfusion
- Phase Equilibria and Thermodynamics
- Thermodynamic properties of mixtures
- Atrial Fibrillation Management and Outcomes
- Renal cell carcinoma treatment
- Virology and Viral Diseases
- Fetal and Pediatric Neurological Disorders
- Rabies epidemiology and control
- Hormonal Regulation and Hypertension
- Pharmacological Receptor Mechanisms and Effects
- Molecular spectroscopy and chirality
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Vectors
- Catalysis and Oxidation Reactions
- Heart Failure Treatment and Management
- Galectins and Cancer Biology
Philipps University of Marburg
2016-2025
National and Kapodistrian University of Athens
1998-2021
University of Ha'il
2021
Hippocration General Hospital
2021
Background: Cardiogenic shock remains a significant cause of mortality in patients with acute coronary syndrome, despite early interventions, such as revascularization. Mechanical circulatory support devices, particularly venoarterial extracorporeal membrane oxygenation (VA-ECMO), are increasingly being utilized to address this issue. Limited randomized controlled trials (RCTs) exist evaluate the efficacy VA-ECMO cardiogenic related syndrome. Methods: A meta-analysis was conducted assess...
Background: Cardiogenic shock (CS), characterized by inadequate tissue perfusion due to cardiac dysfunction, has a high mortality rate despite advances in treatment. Systemic inflammation and organ failure exacerbate the severity of CS. Extracorporeal hemadsorption techniques such as CytoSorb® have been introduced control inflammation. However, evidence their efficacy, particularly patients on various mechanical circulatory support (MCS) systems, remains limited. Methods: This retrospective...
Background: Transcatheter aortic valve replacement (TAVR) is the standard treatment for stenosis (AS), particularly in elderly or high-risk surgical patients. The New York Heart Association (NYHA) classification, which assesses severity of heart failure (HF), a key factor influencing TAVR outcomes. However, its impact on procedural success, complications, and outcomes remains underrepresented recent studies. Methods: In this multicenter study, data from 2,256 patients who underwent between...
Abstract Background Despite continuous advances in post-resuscitation management, the outcome after out-of-hospital cardiac arrest (OHCA) is limited. To improve outcome, interdisciplinary centres (CACs) have been established recent years, but survival remains low, and treatment strategies vary considerably clinical geographical aspects. Here we analysed a strategy of in-hospital management while evaluating outcome. Methods A broad spectrum pre- parameters 545 resuscitated patients admitted...
OBJECTIVES: Early mechanical circulatory support with Impella may improve survival outcomes in the setting of postcardiac arrest cardiogenic shock after out-of-hospital cardiac complicating acute myocardial infarction. However, optimal timing to initiate this particular remains unclear. Therefore, we aimed compare patients supported 2.5 before percutaneous coronary intervention (pre-PCI) those (post-PCI). DESIGN: Retrospective single-center study between September 2014 and December 2019...
To evaluate the effects of left ventricular support with microaxial pump using Impella device on renal resistive index assessed by Doppler ultrasonography in haemodynamically stable patients cardiogenic shock following myocardial infarction.A non-randomised interventional single-centre study. Consecutive supported an were included during May 2018 and October 2018. The determined as a quotient (peak systolic velocity - end diastolic velocity)/ peak was obtained ultrasound; invasive blood...
Post-cardiac arrest syndrome (PCAS) after out-of-hospital cardiac (OHCA) poses significant challenges due to its complex pathomechanisms involving inflammation, ischemia, and reperfusion injury. The identification of early available prognostic indicators is essential for optimizing therapeutic decisions improving patient outcomes.
Abstract Background Percutaneous mechanical circulatory devices are increasingly used in patients with cardiogenic shock (CS). As evidence from randomized studies comparing these lacking, optimal choice of the device type is unclear. Here we aim to compare outcomes CS supported either Impella or vaECMO. Methods Retrospective single-center analysis CS, September 2014 2019. Patients were assisted 2.5/CP ultimately both analyzed according first implanted. Primary hospital and 6-month survival....
This study was performed to identify coexisting structural lesions in patients with epilepsy and known temporal encephaloceles (TEs).Forty-seven magnetic resonance imaging (MRI) scans of radiologically diagnosed TEs were retrospectively reviewed visually using an automated postprocessing software, the Morphometric Analysis Program v2018 (MAP18), depict additional subtle, potentially epileptogenic 3D T1-weighted MRI data. All findings evaluated context clinical electroencephalographical...
Objectives. Studies have evaluated the association of galectin-3 and outcome in patients with heart failure. However, there is still scarce evidence concerning clinical usefulness predictive value for left ventricular reverse remodeling (LVRR) recent-onset dilated cardiomyopathy (RODCM). Patients Methods. Baseline was measured 57 RODCM. All were followed at least 12 months. The study end point LVRR months, defined as an absolute improvement ejection fraction ≥10% to a final ≥35%, accompanied...
Acute kidney injury is one of the most frequent and prognostically relevant complications in cardiogenic shock. The purpose this study was to evaluate potential effect Impella® pump on hemodynamics renal organ perfusion patients with myocardial infarction complicating Between January 2020 February 2022 infarct-related shock supported were included single-center prospective short-term study. Changes different levels support documented invasive pulmonal arterial catheter. As far as function...
Background: Cardiogenic shock (CS) following an out-of-hospital cardiac arrest (OHCA) poses significant management challenges, exacerbated by inflammatory responses and infectious complications. This study investigates the microbiological profiles impacts of mechanical circulatory support (MCS) on inflammation infection in OHCA patients. Methods: We retrospectively analyzed data from various specimens 372 patients, who were treated at Cardiac Arrest Center University Hospital Marburg January...
Our aim was to compare the outcomes of Impella with extracorporeal life support (ECLS) in patients post-cardiac arrest cardiogenic shock (CS) complicating acute myocardial infarction (AMI). This a retrospective study resuscitated from out hospital cardiac (OHCA) CS following AMI (May 2015 May 2020). Patients were supported either 2.5/CP or ECLS. Outcomes compared using propensity score-matched analysis account for differences baseline characteristics between groups. 159 included (Impella, n...
Background: Little is known about the impact of treatment with inotropic drugs on interaction hemodynamics, biomarkers, and end-organ function in patients acute decompensated heart failure (HF) different origins rhythms. Methods: Fifty causes HF (dilated cardiomyopathy DCM, ischemic ICM, atrial fibrillation AF, sinus rhythm/pacemaker lead rhythm SR/PM) were treated dobutamine or levosimendan. Non-invasive parameters renal organ evaluated at hospital admission after myocardial recompensation...
Background. Although scoring systems are widely used to predict outcomes in postcardiac arrest cardiogenic shock (CS) after out-of-hospital cardiac (OHCA) complicating acute myocardial infarction (AMI), data concerning the accuracy of these scores mortality patients treated with Impella this setting lacking. Thus, we aimed evaluate as well compare prognostic physiology and chronic health II (APACHE II), simplified score (SAPS sepsis-related organ failure assessment (SOFA), intra-aortic...
Since mechanical circulatory support (MCS) devices have become integral component in the therapy of refractory cardiogenic shock (RCS), we identified 67 patients biventricular with Impella and venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO) for RCS between February 2013 December 2019 evaluated risk factors mortality this setting. Mean age was 61.07 ± 10.7 54 (80.6%) were male. Main cause acute myocardial infarction (AMI) (74.6%), while 44 (65.7%) resuscitated prior to admission....
Although the use of microaxilar mechanical circulatory support systems may improve outcome patients with cardiogenic shock (CS), little is known about its effect on long-term structural integrity left ventricular (LV) valves as well development LV-architecture. Therefore, we aimed to study LV and architecture function after Impella support. Thus, 84 consecutive were monitored over two years having received ImpellaTM CP (n = 24) or 2.5 60) for refractory CS 62) high-risk percutaneous coronary...
Background: Capnocytophaga, a bacteria native to the oral flora of canines, in rare cases can lead severe infections resulting septic shock, respiratory tract infection, and multiple organ failure. In case trauma following animal bites with rapidly progressing clinical courses, also adjunctive therapeutic measures such as extracorporeal blood purification therapies might be beneficial. Case presentation: We report on 68-year-old male who was hospitalized fever, oliguria repeated vomiting...