A5048334186- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
- Advanced MRI Techniques and Applications
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Electrostatic Discharge in Electronics
- Heart Rate Variability and Autonomic Control
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Vascular anomalies and interventions
University of Göttingen
2022-2025
University Medical Center
2025
Universitätsmedizin Göttingen
2024
Heart and Diabetes Center North Rhine-Westphalia
2020-2024
Bielefeld University
2024
Ruhr University Bochum
2021
Abstract Purpose Pulsed-field ablation (PFA) is a new energy source to achieve pulmonary vein isolation (PVI) by targeted electroporation of cardiomyocytes. Experimental and controlled clinical trial data suggest good efficacy PFA-based PVI. We aimed assess efficacy, safety follow-up PVI in an early adopter routine care setting. Methods Consecutive patients with symptomatic paroxysmal or persistent atrial fibrillation (AF) underwent using the Farawave® PFA catheter conjunction...
BackgroundThe CASTLE-HTx trial demonstrated the benefit of atrial fibrillation (AF) ablation compared to medical therapy in decreasing mortality, need for left ventricular assist device (LVAD) implantation or heart transplantation (HTx) patients with end-stage failure (HF).ObjectivesThe aim this analysis was identify risk factors related adverse outcomes HF and assess impact ablation.MethodsThe protocol randomized 194 AF versus therapy. We identified ejection fraction (LVEF) <30%, NYHA-class...
Abstract Aims Accessory pathway (AP) ablation is a standard procedure for the treatment of Wolff-Parkinson-White syndrome (WPW). Twelve-lead electrocardiogram (ECG)-based delta wave analysis essential predicting sites. Previous algorithms have shown to be complex, time-consuming, and unprecise. We aimed retrospectively develop prospectively validate new, simple ECG-based algorithm considering patients’ heart axis allowing exact localization APs in patients undergoing WPW. Methods results Our...
Cryoballoon (CB)-guided pulmonary vein isolation (PVI) represents a cornerstone in the treatment of atrial fibrillation (AF). Recently, novel balloon-guided single shot device (POLARx, Boston Scientific) was designed. Our study aimed to compare efficacy, safety and characteristics CB system with established one (Arctic Front Advance (Pro), AFA, Medtronic). A total number 596 patients undergoing CB-guided ablation for AF were included. 65 (65.0 ± 11.6, 31% female) PVI POLARx compared cohort...
Cardioneuroablation is a treatment option for patients with recurrent vasovagal syncope (VVS). Ablation targets of parasympathetic ganglionated plexi (GP) adjacent to the right and left atrial walls distal endocardial inputs these GP can be identified both by their anatomical localization intracardiac mapping fragmented electrogram signals. In this case successful cardioneuroablation 22-year-old patient suffering from VVS, new algorithm automatic signals (CARTO Elevate Module, Biosense...
Cryoballoon (CB)-guided pulmonary vein isolation (PVI) is an established treatment for atrial fibrillation (AF). This study aimed to evaluate ablation efficacy and freedom from arrhythmia recurrence using the novel POLARx compared Arctic Front Advance Pro (AFA) CB system including analysis of individual PV characteristics.A total 687 patients underwent CB-guided AF. Arrhythmia was defined as ECG documented episode any AF/atrial tachycardia (AT) > 30 s. Anatomical characteristics were...
Aims: The CARTOFINDER module allows for simultaneous and automated detection of repetitive focal rotational activations in patients with atrial arrhythmias. This study aimed to validate the algorithm potential drivers fibrillation (AF) access their impact on individual arrhythmia substrates. Methods: Fifty consecutive underwent AF ablation persistent (PERS), using a 3D-mapping system integrated module. Regions interest (ROIs) were identified before after ablation, spatial temporal...
Abstract Aims The CASTLE‐HTx trial showed the benefit of atrial fibrillation (AF) ablation compared to medical therapy in decreasing mortality, need for left ventricular assist device implantation or heart transplantation (HTx) patients with end‐stage failure (HF). Herein we describe effects catheter on AF burden, arrhythmia recurrences, and function HF. Methods results protocol randomized 194 HF alone. ejection fraction (LVEF), type were assessed at baseline each follow‐up visit. Overall,...
Abstract Background Data comparing remote magnetic catheter navigation (RMN) with manual (MCN) ablation of atrial fibrillation (AF) is lacking. The aim the present prospective observational study was to compare outcome RMN versus (vs.) MCN AF regards recurrence. Methods comprised 667 consecutive patients a total 939 procedures: 287 were ablated using RMN, 380 MCN. Results There no significant difference between groups at baseline. After 2.3 ± years follow‐up, 23% in group remained free...
Cryoballoon-guided pulmonary vein isolation (CB-PVI) for symptomatic atrial fibrillation (AF) has become an established treatment option with encouraging results in terms of safety and efficacy. Data reporting on long-term data beyond a follow-up (FU) period 5 years is scarce. This prospective study aimed to evaluate very outcome after CB-PVI AF.Data from consecutive patients treated drug refractory AF between 2005 2012 were analyzed. Patients FU ≥9 index included. All continuously...
Remote magnetic navigation (RMN) facilitates ventricular arrhythmia (VA) ablation. This study aimed to evaluate the long-term efficacy of RMN-guided ablation for tachycardia (VT) and premature contractions (PVC). A total 176 consecutive patients (mean age 53.23 ± 17.55 years, 37% female) underwent VA PVC (132 patients, 75%) or VT (44 25%). The cohort consisted 119 (68%) with idiopathic VA, 31 (18%) ischemic (ICM), 26 (15%) dilated cardiomyopathy (DCM). recurrence was observed in 69 (39%,...
Approaches applying higher energy levels for shorter periods (high power short duration, HPSD) to improve lesion formation atrial fibrillation (AF) ablation have been introduced. This single-center study aimed compare the efficacy, safety, and using novel DiamondTemp (DT) catheter or an index (AI)-guided HPSD protocol a force-sensing with surround-flow irrigation.One hundred thirteen consecutive patients undergoing radiofrequency-guided (RFCA) AF were included. Forty-five treated DT (50 W, 9...
Cryoballoon (CB)-guided pulmonary vein isolation (PVI) is an established treatment for atrial fibrillation (AF). This observational study aimed to assess the role of individual anatomical characteristics predict long-term freedom from arrhythmia recurrence after CB-guided PVI paroxysmal AF (PAF).Three hundred fifty three consecutive patients (58 ± 11 years, 56% males), undergoing between 2012 and 2018 were analysed. Individual (PV) anatomy was assessed using preprocedural cardiac magnetic...
The present study describes our experience with a new mapping approach for ventricular arrhythmia (VA) ablation in patients structural heart disease (SHD). Consecutive undergoing catheter recurrent VA were analyzed. High-density was conducted all patients. In inducible VA, local activation time (LAT) and novel vector-based algorithm implemented to analyze propagation. case of focal tachycardia, the location earliest targeted. VAs re-entrant mechanisms, zones slow conduction based on coherent...
The DiamondTemp (DT) radiofrequency ablation (RFA) catheter has been introduced as a new tool for atrial fibrillation (AF) ablation. technology allows temperature-controlled irrigated and real-time lesion assessment. Recently, the EnSite X mapping system became commercially available allowing omnipolar ultra-high-resolution mapping. We aimed to assess feasibility of DT RFA in performing AF procedures conjunction with novel under routine clinical conditions.We analyzed data from 10...
In atrial fibrillation (AF) patients, catheter ablation of pulmonary veins (PVI) is the most effective therapeutic option to maintain sinus rhythm. To improve successful PVI, contact force-sensing (CF) catheters became routinely available. Previous studies did not clearly show superior clinical efficacy in comparison with non-CF catheters.We investigated consecutive who underwent index PVI for AF at our hospital between 2012 and 2018. Three hundred fifty-four patients were ablated without...
Abstract Background Multielectrode mapping catheters improve the detection of scarred and fibrotic tissue in patients with atrial fibrillation (AF) Recently, a novel multispline catheter 48 closely spaced microelectrodes has been introduced enabling fast high-resolution electroanatomical mapping. Objective This study sought to report our initial clinical experience Octaray AF undergoing index ablation compare its impact on 5-spline Pentaray catheter. Methods The included consecutive who...
Abstract Background Data comparing remote magnetic catheter navigation (RMN) with manual in combination contact force sensing (MCN-CF) ablation of atrial fibrillation (AF) is lacking. The primary aim the present retrospective comparative study was to compare outcome RMN versus (vs.) MCN-CF AF regards recurrence. Secondary analyze periprocedural risk, characteristics and repeat procedures. Methods We retrospectively analyzed 452 patients undergoing a total 605 ablations AF: 180 were ablated...