A5081454088- Acute Myeloid Leukemia Research
- Advanced Radiotherapy Techniques
- Cardiac Arrhythmias and Treatments
- Radiation Therapy and Dosimetry
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Sarcoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Renal and related cancers
- Chronic Myeloid Leukemia Treatments
- Radiopharmaceutical Chemistry and Applications
- Management of metastatic bone disease
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Histone Deacetylase Inhibitors Research
- Spinal Fractures and Fixation Techniques
- Cardiac Imaging and Diagnostics
Amsterdam University Medical Centers
2018-2025
University of Amsterdam
2018-2024
Amsterdam UMC Location University of Amsterdam
2017-2019
Radiation Oncology Associates
2012-2015
Boston Children's Hospital
2010-2012
Erasmus MC - Sophia Children’s Hospital
2007-2011
Erasmus University Rotterdam
2010
Erasmus MC
2007
University Medical Center Utrecht
2005
Background Several studies of pediatric acute myeloid leukemia have described the various type-I or type-II aberrations and their relationship with clinical outcome. However, there has been no recent comprehensive overview these genetic in one large cohort.Design Methods We studied different aberrations, associations impact on prognosis a series (n=506). Karyotypes were studied, hotspot regions NPM1, CEPBA, MLL, WT1, FLT3, N-RAS, K-RAS, PTPN11 KIT screened for mutations available samples....
Abstract Aims Stereotactic arrhythmia radiotherapy (STAR) is suggested as potentially effective and safe treatment for patients with therapy-refractory ventricular tachycardia (VT). However, the current prospective knowledge base experience STAR limited. In this study we aimed to prospectively evaluate efficacy safety of STAR. Methods results The StereoTactic Arrhythmia Radiotherapy in Netherlands no.1 was a pre-post intervention VT, pro-arrhythmic region treated 25 Gy single fraction. main...
Background Pediatric acute myeloid leukemia is a heterogeneous disease characterized by non-random genetic aberrations related to outcome. The subtype currently detected different diagnostic procedures which differ in success rate and/or specificity.Design and Methods We examined the potential of gene expression profiles classify pediatric leukemia. Gene microarray data 237 children with were collected double-loop cross validation approach was used generate subtype-predictive profile...
Background Dysfunctioning of CCAAT/enhancer binding protein α (C/EBPα) in acute myeloid leukemia can be caused, amongst others, by mutations the encoding gene (CEBPA) and promoter hypermethylation. CEBPA-mutated is associated with a favorable outcome, but this may restricted to case double CEBPA adult leukemia. In pediatric leukemia, data on impact these are limited one series, hypermethylation lacking. Our objective was investigate characteristics, expression profiles prognostic different...
Cardiac radioablation has evolved as a potential treatment modality for therapy-refractory ventricular tachycardia. To standardize cardiac treatments, promote accurate communication and target identification, to assess toxicity, robust, reproducible methods angulation segmentation are paramount. In this study, we developed evaluated tool semiautomated according the American Heart Association 17-segment model.
In patients with recurrent ventricular tachycardia (VT), STereotactic Arrhythmia Radioablation (STAR) shows promising results. The STOPSTORM.eu consortium was established to investigate and harmonise STAR treatment in Europe. primary goals of this benchmark study were standardise contouring organs at risk (OAR) for STAR, including detailed substructures the heart, accredit each participating centre.Centres within asked delineate 31 OAR three cases. Delineation reviewed by expert panel after...
(1) Background: Orbital rhabdomyosarcoma is a rare and aggressive soft tissue tumor that primarily occurs in the eye socket (orbit) of children. Treatment usually involves combination surgery, chemotherapy, radiation therapy, aiming to remove prevent metastasis. (2) Methods: An institutional retrospective study was conducted with data from 39 patients primary orbital RMS treated between 1995 2016 at Amsterdam University Medical Centers/Emma Children Hospital. (3) Results: The median age...
Highlights•Cardiac substructure auto-contouring using deep learning (nnUNet) for VT patients.•Multi-institutional multi-modal training dataset.•Performance testing based on data from more than 20 observers.•Model performance equal to manual inter-observer variability.•All trained models available online: https://zenodo.org/records/13752275.AbstractBackground/PurposeHigh doses healthy cardiac substructures (CS) in stereotactic arrhythmia radioablation (STAR) raise concerns regarding potential...