V. Ferrero
A5027406104- Radiation Therapy and Dosimetry
- Radiation Detection and Scintillator Technologies
- Advanced Radiotherapy Techniques
- Radiation Effects in Electronics
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Particle Detector Development and Performance
- Boron Compounds in Chemistry
- Advances in Oncology and Radiotherapy
- Electric Power System Optimization
- Atomic and Subatomic Physics Research
- Electron and X-Ray Spectroscopy Techniques
- Ion-surface interactions and analysis
- Radiation Shielding Materials Analysis
- Radioactivity and Radon Measurements
- Biomedical and Engineering Education
- Infrared Target Detection Methodologies
- Energy Load and Power Forecasting
- Age of Information Optimization
- Chemical Reactions and Isotopes
- Laser-Plasma Interactions and Diagnostics
- Graphite, nuclear technology, radiation studies
- Environmental Monitoring and Data Management
- Diamond and Carbon-based Materials Research
- Scientific Computing and Data Management
University of Turin
2016-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Torino
2016-2024
Universidad de León
2024
Istituto Nazionale di Fisica Nucleare
2017-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2021
National University of Science and Technology
2021
Particle therapy exploits the energy deposition pattern of hadron beams. The narrow Bragg Peak at end range is a major advantage but uncertainties can cause severe damage and require online verification to maximise effectiveness in clinics. In-beam Positron Emission Tomography (PET) non-invasive, promising in-vivo technique, which consists measurement β+ activity induced by beam-tissue interactions during treatment, presents highest correlation measured distribution with deposited dose,...
The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators the plan correctness. Among available imaging techniques, positron emission tomography (PET) has long been investigated then clinically applied to proton carbon beams. In 2013, Innovative Solutions for Dosimetry in Hadrontherapy (INSIDE) collaboration proposed an innovative bimodal concept combines in-beam PET scanner with tracking...
Objective. In this study we introduce spatiotemporal emission reconstruction prompt gamma timing (SER-PGT), a new method to directly reconstruct the photon in space and time domains inside patient proton therapy.Approach. SER-PGT is based on numerical optimisation of multidimensional likelihood function, followed by post-processing results. The current approach relies specific implementation maximum-likelihood expectation maximisation algorithm. robustness guaranteed complete absence any...
Monitoring Ultra-High Dose Rate (UHDR) beams is one of the multiple challenges posed by emergent FLASH radiotherapy. Technologies (i.e., gas-filled ionization chambers) nowadays used in conventional radiotherapy are no longer effective when applied to UHDR regimes, due recombination effect they affected by, and time required collect charges. Exploiting expertise field silicon sensors’ applications into clinics, medical physics group University INFN Torino investigating thin sensors as...
In vivo range monitoring techniques are necessary in order to fully take advantage of the high dose gradients deliverable hadrontherapy treatments. Positron emission tomography (PET) scanners can be used monitor beam-induced activation tissues and hence measure range. The INSIDE (Innovative Solutions for In-beam DosimEtry Hadrontherapy) in-beam PET scanner, installed at Italian National Center Oncological Hadrontherapy (CNAO, Pavia, Italy) synchrotron facility, has already been successfully...
In particle therapy, the uncertainty of delivered range during patient irradiation limits optimization treatment planning. Therefore, an in vivo verification device is required, not only to improve plan robustness, but also detect significant interfractional morphological changes itself. this article, effective and robust analysis regions with a discrepancy proposed. This study relies on by means in-beam Positron Emission Tomography (PET) was carried out INSIDE system installed at National...
Abstract FOOT (FragmentatiOn Of Target) is a nuclear physics experiment currently under construction that will measure differential cross sections for the production of secondary fragments induced by interactions proton and ion beams, up to 400 MeV/u, with human tissues. By extending energy range about 800 also provide data useful radio-protection in space, as understanding fragmentation processes take place spacecraft shieldings crucial their optimisation. The collaboration building...
Abstract The high dose conformity and healthy tissue sparing achievable in Particle Therapy when using C ions calls for safety factors treatment planning, to prevent the tumor under-dosage related possible occurrence of inter-fractional morphological changes during a treatment. This limitation could be overcome by range monitor, still missing clinical routine, capable providing on-line feedback. Dose Profiler (DP) is detector developed within INnovative Solution In-beam Dosimetry...
Morphological changes that may arise through a treatment course are probably one of the most significant sources range uncertainty in proton therapy. Non-invasive in-vivo monitoring is useful to increase quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs and carbon therapy treatments at National Center Oncological Hadrontherapy (CNAO). It currently clinical trial (ID: NCT03662373) has acquired PET data during various patients. In this work we analyze (IB-PET)...
Goal:In-beam Positron Emission Tomography (PET) is a technique for in-vivo non-invasive treatment monitoring proton therapy. To detect anatomical changes in patients with PET, various analysis methods exist, but their clinical interpretation problematic. The goal of this work to investigate whether the gamma-index analysis, widely used dose comparisons, an appropriate tool comparing in-beam PET distributions. Focusing on head-and-neck patient, we map and passing rate are sensitive...
Gold nanoparticles (GNPs) are being proposed in combination with radiotherapy to improve tumor control. However, the exact mechanisms underlying GNP radiosensitization yet be understood, thus, we present a new approach estimate nanoparticle-driven increase radiosensitivity.A stochastic radiobiological model, derived from Local Effect Model (LEM), was coupled Monte Carlo simulations radiosensitivity produced by interactions between photons and GNPs at nanometric scale. The model validated...
Treatment quality assessment is a crucial feature for both present and next-generation ion therapy facilities. Several approaches are being explored, based on prompt radiation emission or PET signals by [Formula: see text]-decaying isotopes generated beam interactions with the body. In-beam monitoring at synchrotron-based facilities has already been performed, either inter-spill data only, to avoid influence of radiation, including in-spill data. However, images suffer poor statistics...
Positron emission tomography (PET) is a well established imaging technique for range monitoring in hadrontherapy. Multiple fields are standard protocol treatments, but because of washout and residual activity background from previous irradiation plans, to this date quantitative verification the particle each beam field still an open issue. In paper, new method evaluation with PET detector second treatment discussed. Two plans two parallel-opposed fields, one using protons carbon ions, were...
Particle therapy in which deep seated tumours are treated using 12 C ions (Carbon Ions RadioTherapy or CIRT) exploits the high conformity dose release, relative biological effectiveness and low oxygen enhancement ratio of such projectiles. The advantages CIRT driving a rapid increase number centres that trying to implement technique. To fully profit from ballistic precision achievable delivering target volume an online range verification system would be needed, but currently missing. beams...
Introduction: Charged Particle Therapy plays a key role in the treatment of deep-seated tumours, because advantageous energy deposition culminating Bragg peak. However, knowledge dose delivered entrance channel is limited by lack data on beam and fragmentation target. Methods: The FOOT experiment has been designed to measure cross sections nuclear projectile target with two different detectors: an electronic setup for identification Z ≥ 3 fragments emulsion spectrometer ≤ fragments. In this...
Irradiations at Ultra-High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radiotherapy with reduced harm normal tissues. This work details the hardware and software modifications implemented deliver 10 MeV UHDR electron beams a linear accelerator Elekta SL 18 MV beam characteristics obtained. GafChromic EBT XD films Advanced Markus chamber were used for dosimetry characterization,...
Quality assessment of particle therapy treatments by means PET systems has been carried out since late `90 and it is one the most promising in-vivo non invasive monitoring techniques employed clinically. It can be performed with a diagnostic scanners installed outside treatment room (off-line monitoring) or inside (in-room monitoring). However efficient way integrating scanner delivery system (on-line so that biological wash patient repositioning errors are minimized. In this work we present...
In-beam positron emission tomography (PET) is one of the modalities that can be used for in vivo noninvasive treatment monitoring proton therapy. Although PET has been frequently applied this purpose, there still no straightforward method to translate information obtained from images into easy-to-interpret clinical personnel. The purpose work propose a statistical analyzing in-beam locate, quantify, and visualize regions with possible morphological changes occurring over course treatment.We...
Background and purpose: In-beam Positron Emission Tomography (PET) is one of the modalities that can be used for in-vivo non-invasive treatment monitoring in proton therapy. PET distributions obtained during various sessions compared order to identify regions have anatomical changes. The purpose this work test compare different analysis methods context inter-fractional image comparison verification. Methods: For our study we FLUKA Monte Carlo code artificially generated CT scans simulate...