A5089554789- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Radiation Dose and Imaging
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Advanced X-ray and CT Imaging
- Prostate Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Effects of Radiation Exposure
- CAR-T cell therapy research
- Radiation Detection and Scintillator Technologies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Management of metastatic bone disease
- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Neuroendocrine Tumor Research Advances
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Spaceflight effects on biology
Azienda USL di Bologna
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2022-2025
University of Bologna
2021-2024
Policlinico S.Orsola-Malpighi
2015-2024
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2022
Expert System (Italy)
2011-2020
Istituti Fisioterapici Ospitalieri
2010-2020
Instituto Nazionale Tumori Regina Elena
2013-2020
Tumori Foundation
2020
Abstract Purpose A multidisciplinary expert panel convened to formulate state-of-the-art recommendations for optimisation of selective internal radiation therapy (SIRT) with yttrium-90 ( 90 Y)-resin microspheres. Methods steering committee 23 international experts representing all participating specialties formulated SIRT Y-resin microspheres activity prescription and post-treatment dosimetry, based on literature searches the responses a 61-question survey that was completed by 43 leading...
The possibility to combine Low Intensity UltraSound (LIUS) and Nanoparticles (NP) could represent a promising strategy for drugs delivery in tumors difficult treat overcoming resistance therapies. On one side the NP can carry that specifically target on other LIUS facilitate direct tumor cells. In this study, we investigated whether Very (VLIUS), at intensities lower than 120 mW/cm2, might constitute novel improve Thus, order verify efficacy of modality terms increase selective uptake...
This study aimed to describe 2 types of endometriosis-associated ovarian cancer: those with transitional elements (atypical endometriosis and borderline tumors) termed endometriosis-correlated or incidental benign vs cancer cases not associated endometriosis. was a prospective, observational, monocentric conducted from November 2021 December 2023. Patients eligible for surgery were enrolled classified into carcinoma, endometriosis-incidental carcinoma without groups based on the presence...
Radioactive <sup>90</sup>Y-selective internal radiation (SIR) sphere therapy is increasingly used for the treatment of nonresectable hepatocellular carcinoma (HCC). However, maximum delivered dose limited by severe injury to nontarget tissue, including liver parenchyma. Our study aimed implement radiobiologic models both tumor control probability (TCP) and normal-tissue complication (NTCP) describe more effectively local response toxicity rate, respectively. <b>Methods:</b> Patients with...
Purpose To report the final results on treatment outcomes of a randomized trial comparing conventional and hypofractionated radiotherapy in high-risk, organ-confined prostate cancer (PCa). Patients Methods This single-institution, clinical trial, conducted from January 2003 to December 2007, enrolled 168 patients with high-risk PCa who were randomly assigned 1:1 ratio (80 Gy 40 fractions 8 weeks) or (62 20 5 seminal vesicles. The primary outcome measure was late toxicity. Additional freedom...
To investigate the potential dosimetric and clinical benefits of Deep Inspiration Breath-Hold (DIBH) technique during radiotherapy breast cancer compared with Free Breathing (FB).Eight left-sided patients underwent a supervised breath hold treatment. For each patient, two CT scans were acquired without hold, virtual simulation was performed for conventional tangential fields, utilizing 6 or 15 MV photon fields. The resulting dose-volume histograms calculated, volumes heart/lung irradiated to...
Abstract Context We compared the efficacy, safety, and effect of 45-day isocaloric very-low-calorie ketogenic diets (VLCKDs) incorporating whey, vegetable, or animal protein on microbiota in patients with obesity insulin resistance to test hypothesis that source may modulate response VLCKD interventions. Subjects Methods Forty-eight (19 males 29 females, homeostatic model assessment (HOMA) index ≥ 2.5, aged 56.2 ± 6.1 years, body mass [BMI] 35.9 4.1 kg/m2) were randomly assigned three...
// Andrea Botticelli 1, 2 , Concetta Elisa Onesti Ilaria Zizzari 3 Bruna Cerbelli 4 Paolo Sciattella 5 Mario Occhipinti 1 Michela Roberto Francesca Di Pietro Adriana Bonifacino 6 Michele Ghidini 7 Patrizia Vici 8 Laura Pizzuti Chiara Napoletano Lidia Strigari 9 Giulia D'Amati Federica Mazzuca Marianna Nuti and Marchetti Medical Oncology Department, Sant'Andrea Hospital, Rome, Italy Department of Clinical Molecular Medicine, "Sapienza" University Experimental Radiological Oncological...
Abstract The aim of this standard operational procedure is to standardize the methodology employed for evaluation pre- and post-treatment absorbed dose calculations in 90 Y microsphere liver radioembolization. Basic assumptions include permanent trapping microspheres, local energy deposition method voxel dosimetry, patient–relative calibration activity quantification.The identity 99m Tc albumin macro-aggregates (MAA) biodistribution also assumed. large observed discrepancies some patients...
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer worldwide. They are typically characterized by a high incidence of local recurrence, which most common cause death in HNSCC patients. TP53 frequently mutated gene patients carrying mutations associated with higher probability to develop recurrence. MiRNAs, among mediators oncogenic activity mt-p53 protein, emerge as an appealing tool for screening, diagnosis prognosis cancer. We previously identified signature 12...
Radiopharmaceutical therapy (RPT) is a radiation delivery modality that uses radionuclides to irradiate tissues with various forms of ionizing radiation. In most RPT, the radionuclide targeted diseased tissue following systemic administration pharmaceutical circulates throughout body and delivers sites radiopharmaceutical accumulation. Three major classes are used in RPT including beta-particle emitters, alpha-particle Auger-electron emitters. Recent therapeutic successes regulatory approval...
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) are innovative small target molecules that, in combination with endocrine therapy, have recently been employed the treatment of patients HR+/HER2- metastatic breast cancer (mBC). In this prospective study, we investigate impact CDK4/6i on immune profile mBC.Immune cell subsets were analysed using flow cytometry peripheral blood mononuclear cells (PBMCs) isolated from mBC, both before and during treatment. Regulatory T (Tregs) identified...