A5035282867- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Cardiac Imaging and Diagnostics
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Bacterial Genetics and Biotechnology
- Multiple Myeloma Research and Treatments
- Advanced X-ray and CT Imaging
- Neuroblastoma Research and Treatments
- Prostate Cancer Treatment and Research
- DNA Repair Mechanisms
- Alzheimer's disease research and treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Dementia and Cognitive Impairment Research
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
University of Oslo
2017-2025
Oslo University Hospital
2016-2025
OsloMet – Oslo Metropolitan University
2014-2019
Cancer Registry of Norway
2011
The purpose of the EANM Dosimetry Committee is to provide recommendations and guidance scientists clinicians on patient-specific dosimetry. Radiopharmaceuticals labelled with lutetium-177 (177Lu) are increasingly used for therapeutic applications, in particular treatment metastatic neuroendocrine tumours using ligands somatostatin receptors prostate adenocarcinoma small-molecule PSMA-targeting ligands. This paper provides an overview reported dosimetry data these therapies summarises current...
Abstract The aim of this standard operational procedure is to standardize the methodology employed for evaluation pre- and post-treatment absorbed dose calculations in 90 Y microsphere liver radioembolization. Basic assumptions include permanent trapping microspheres, local energy deposition method voxel dosimetry, patient–relative calibration activity quantification.The identity 99m Tc albumin macro-aggregates (MAA) biodistribution also assumed. large observed discrepancies some patients...
Abstract The numbers of diagnostic and therapeutic nuclear medicine agents under investigation are rapidly increasing. Both novel emitters carrier molecules require careful selection measurement procedures. This document provides guidance relevant to dosimetry for first-in human early phase clinical trials such agents. guideline includes a short introduction different molecules, followed by recommendations on the methods activity measurement, pharmacokinetic analyses, as well absorbed dose...
The European directive on basic safety standards (Council 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. comes into operation February 2018, and the aim of a report produced by Internal Dosimetry Task Force Association Nuclear Medicine is to address this aspect directive. A summary presented. brief review five most common therapy procedures included in current text, focused potential perform patient-specific dosimetry. In full report, 11...
Currently, the implementation of dosimetry in molecular radiotherapy (MRT) is not well investigated, and view Council Directive (2013/59/Euratom), there a need to understand current availability dosimetry-based MRT clinical practice research studies. The aim this study was assess across European countries. An electronic questionnaire distributed This addressed 18 explicitly considered therapies, for each therapy, similar set questions were included. Questions covered number patients...
The purpose of the EANM Dosimetry Committee Series on "Standard Operational Procedures for Dosimetry" (SOP) is to provide advice scientists and clinicians how perform patient-specific absorbed dose assessments. This SOP describes image data acquisition parameters dosimetry calculations determine doses delivered whole-body, tumour normal organs following a therapeutic administration
Hematologic toxicity, although often transient, is the most common limiting adverse effect during somatostatin peptide receptor radionuclide therapy. This study investigated association between Monte Carlo–derived absorbed dose to red marrow (RM) and hematologic toxicity in patients being treated for their neuroendocrine tumors. <b>Methods:</b> Twenty each receiving 4 treatment cycles of [<sup>177</sup>Lu]Lu-DOTATATE were included. Multiple-time-point <sup>177</sup>Lu SPECT/CT imaging–based...
Many studies are performed on chromosome replication and segregation in Escherichia coli other bacteria capable of complex with C phases spanning several generations. For such investigations an understanding the patterns, including copy numbers origins forks, is crucial for correct interpretation results.Flow cytometry important tool generation experimental DNA distributions cell populations. Here, a Visual Basic based simulation program was written computation theoretical different choices...
Absorbed radiation doses are essential in assessing the effects, e.g. safety and efficacy, of radiopharmaceutical therapy (RPT). Patient-specific absorbed dose calculations target or organ at risk require multiple inputs. These include number disintegrations organ, i.e. time-integrated activities (TIAs) organs, as well other parameters describing process energy deposition tissue (i.e. mean per disintegration, constants, etc). TIAs then estimated by incorporating area under...
Background Alzheimer's disease (AD) remains a clinical diagnosis but biomarkers from cerebrospinal fluid (CSF) and more lately amyloid imaging with positron emission tomography (PET), are important to support of AD. Objective To compare amyloid-β (Aβ) PET in CSF evaluate the prediction Aβ on memory clinic setting. Methods We included 64 patients who had lumbar puncture 18F-Flutemetamol performed within 190 days. was binary classified (Flut+ or Flut-) logistic regression analyses for...
For patients with indolent non-Hodgkin lymphoma who fail initial anti-CD20-based immunochemotherapy or develop relapsed refractory disease, there remains a significant unmet clinical need for new therapeutic approaches to improve outcomes and quality of life. 177Lu-lilotomab satetraxetan is next-generation single-dose CD37-directed radioimmunotherapy (RIT) which was investigated in phase 1/2a study 74 relapsed/refractory B-cell lymphoma, including 57 follicular (FL). To targeting tumor...
We have investigated the replication patterns of two chromosomes bacterium Vibrio cholerae grown in four different media. By combining flow cytometry and quantitative real-time PCR with computer simulations, we show that rich media, V. cells grow overlapping cycles both large chromosome (ChrI) small (ChrII). In Luria-Bertani (LB) medium, initiation occurs at copies ChrI origin ChrII origin. Replication was found to occur end period all growth conditions. Novel cell-sorting experiments marker...
Dosimetry can be a useful tool for personalization of molecular radiotherapy (MRT) procedures, enabling the continuous development theranostic concepts. However, additional resource requirements are often seen as barrier to implementation. This guide discusses dosimetry and demonstrates how regimen tailored available facilities centre. The aim is help centres wishing initiate service but may not have experience or resources some more established therapy centres. multidisciplinary approach...
In preparation for an α-particle therapy trial using 1-7 MBq of 224Ra, the feasibility tomographic SPECT/CT imaging was interest. The nuclide decays in 6 steps to stable 208Pb, with 212Pb as principle photon-emitting nuclide. 212Bi and 208Tl emit high-energy photons up 2,615 keV. A phantom study conducted determine optimal acquisition reconstruction protocol. Methods: spheres a body were filled 224Ra-RaCl2 solution, background compartment water. Images acquired on system. addition, 30-min...
AB001, a prostate-specific membrane antigen (PSMA)–targeted small molecule labeled with the in vivo–generating α-emitter <sup>212</sup>Pb, was investigated in phase 0 trial patients metastatic castration-resistant prostate cancer (mCRPC). The primary objective to explore feasibility of γ-camera imaging assess biodistribution and uptake lesions. <b>Methods:</b> Three progressive mCRPC Eastern Cooperative Oncology Group performance status 1 were included, having levels 0.44, 0.75, 15...
<sup>177</sup>Lu-lilotomab satetraxetan is a novel antibody radionuclide conjugate currently tested in phase 1/2a first-in-human dosage escalation trial for patients with relapsed CD37+ indolent non-Hodgkin lymphoma. The aim of this work was to develop dosimetric methods and calculate tumor-absorbed radiation doses treated satetraxetan. <b>Methods:</b> Patients were at escalating injected activities (10, 15 20 MBq/kg) different predosing, or without 40 mg unlabeled lilotomab. Eight included...
Lead-212 (212Pb) is a promising radionuclide for targeted therapy, as it decays to α-particle emitter bismuth-212 (212Bi) via β-particle emission. This extends the problematic short half-life of 212Bi. In preparation upcoming clinical trials with 212Pb, feasibility quantitative single photon-emission computed tomography/computed tomography (SPECT/CT) imaging 212Pb was studied, purpose explore possibility individualised patient dosimetric estimation.Both acquisition parameters (combining two...
Abstract Purpose [ 18 F]FDG PET/CT in multiple myeloma (MM) is currently the best technology to demonstrate patchy and extramedullary disease. However, PET has some limitations, imaging with alternative tracers should be explored. In this study, we aimed evaluate performance of F]fluciclovine compared newly diagnosed MM patients. Procedures Thirteen transplant eligible patients were imaged both within 1 week a prospective study. The subjects visually assessed positive or negative for number...