A5003266494- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Radiation Dose and Imaging
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Ovarian cancer diagnosis and treatment
- Pancreatic and Hepatic Oncology Research
- Radiation Therapy and Dosimetry
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Advanced MRI Techniques and Applications
- Gestational Trophoblastic Disease Studies
- Advances in Oncology and Radiotherapy
- Hip disorders and treatments
- Congenital gastrointestinal and neural anomalies
- Liver Disease and Transplantation
- Anorectal Disease Treatments and Outcomes
- Neuroblastoma Research and Treatments
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Ospedale Santa Maria
2013-2024
Azienda Sanitaria Unità Locale di Reggio Emilia
2018-2024
Vita-Salute San Raffaele University
2022-2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2022-2023
University of Turin
2022
TH Bingen University of Applied Sciences
2022
University of Tübingen
2022
IRCCS Ospedale San Raffaele
2022
Essen University Hospital
2022
Kidney dosimetry in 177 Lu and 90 Y PRRT requires 3 to 6 whole-body/SPECT scans extrapolate the peptide kinetics, it is considered time resource consuming. We investigated most adequate timing for imaging time-activity interpolating curve, as well performance of a simplified dosimetry, by means just 1-2 scans. Finally influence risk factors (DOTATOC versus DOTATATE) considered. 28 patients treated at first cycle with DOTATATE 30 DOTATOC underwent SPECT 2 hours, 1, 2, days after...
Abstract Purpose Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and predict response. Dosimetry involves several steps, first which determination activity radiopharmaceutical taken up by an organ/lesion over time. As uncertainties propagate along each subsequent steps (integration time–activity curve, absorbed dose calculation), establishing a reliable quantification essential. The MRTDosimetry project was European initiative bring together expertise in...
In this report, we compared endoscopic ultrasonography (EUS), multidetector CT (MDCT), and Ga-68 DOTATOC PET/CT in patients with neuroendocrine tumors (NETs). We report our experience use of these methods suspected to have duodenopancreatic primitive NET.Nineteen consecutive (mean age, 56; 21-80), who underwent both EUS between March 2007 November 2008 were retrospectively included the study (16 MDCT). Suspicion NET was confirmed by EUS-FNA and/or surgery. Operative characteristics PET, EUS,...
Absorbed radiation doses are essential in assessing the effects, e.g. safety and efficacy, of radiopharmaceutical therapy (RPT). Patient-specific absorbed dose calculations target or organ at risk require multiple inputs. These include number disintegrations organ, i.e. time-integrated activities (TIAs) organs, as well other parameters describing process energy deposition tissue (i.e. mean per disintegration, constants, etc). TIAs then estimated by incorporating area under...
The accurate prediction of prognosis and pattern failure is crucial for optimizing treatment strategies patients with cancer, early evidence suggests that image texture analysis has great potential in predicting outcome both terms local control toxicity. aim this study was to assess the value pretreatment 18F-FDG PET primary head neck squamous cell carcinoma (HNSCC) treated concurrent chemoradiation therapy.We performed a retrospective 90 diagnosed HNSCC between January 2010 June 2017...
Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment uncertainty is complicated and, for that reason, it commonly ignored in clinical routine. However, essential adequate interpretation the results. Recently, EANM published practical guidance on analysis molecular radiotherapy based application law propagation uncertainty. In this study, we investigated overall sample patient following guidelines. The aim...
The aim of this study was to assess the efficacy PRRT in patients with advanced neuroendocrine tumors (NETs). Patients and Methods. From January 2007 August 2011, we enrolled 65 (m/f 38/27; mean age years, range 33-83) NETs having enhanced SSTR expression, treated PRRT. expression assessed using (68)Ga-DOTATOC/DOTATATE PET/CT. Among all patients, 6 them were excluded from present analysis since they voluntarily interrupted treatment. Mean activity/cycle 2.6 GBq ((90)Y-DOTATOC/DOTATATE) or...
A novel radioguided surgery (RGS) technique exploiting β<sup>−</sup> radiation has been proposed. To develop such a technique, suitable radiotracer able to deliver emitter the tumor be identified. first candidate is represented by <sup>90</sup>Y-labeled DOTATOC, compound commonly used today for peptide radioreceptor therapy. The application of this RGS neuroendocrine tumors (NET) requires study uptake DOTATOC and its time evolution both in healthy organs evaluation corresponding performance...
The purpose of this work is to implement a radiobiological model compare different treatment schedules for Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu and 90Y. principal quantities were studied as function radionuclides, fractionation schemes, activity distribution in kidneys tumor radiosensitivity.Clinical data used derive representative absorbed doses several schemes 177Lu-PRRT 90Y-PRRT considered input the model. Both uniform non-uniform distributions cortex; tumors possible...
In spite of the hazard due to radiation exposure, preparation 90 Y- and 177 Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures. present study performance a commercial automatic synthesizer based on disposable cassettes for labelling Lu- Y-DOTA-conjugated biomolecules (namely, DOTATOC PSMA-617) was evaluated compared semiautomated approach. The dose exposure operators as well. More than 300 clinical preparations both have been three different methods. mean...
The present work concerns the comparison of performances three systems for dosimetry in RPT that use different techniques absorbed dose calculation (organ-level dosimetry, voxel-level kernel convolution and Monte Carlo simulations). aim was to assess importance choice most adequate modality, providing recommendations about computation tool.The were evaluated both on phantoms patients a multi-level approach. Different filled with 177Lu-radioactive solution used: homogeneous cylindrical...
The introduction of peptide receptor radionuclide therapy, mainly performed with (90)Y and (177)Lu-labelled somatostatin analogues, has widened the therapeutic horizon nuclear medicine.The handling pharmaceuticals implies an increase personnel exposure this aspect is evaluated in paper, comparison personal manipulation.Personal dose measurements were during 26 (177)Lu-DOTATOC preparations by using a series thin active layer LiF: Mg,Cu,P thermoluminescence dosimeters fixed at operator's...
Beta-emitting radionuclides are being increasingly used in targeted radionuclide therapy nuclear medicine. In particular, the pure high-energy beta-emitter 90Y (Emax=2.27 MeV) has a physical half-life compatible with pharmacokinetics of peptides. The use this isotope implies an increase radiation dose received by medicine staff. aim study is thus evaluation personal beta-dosimetry data related to therapeutic 90Y-labelled DOTA-D-Phe1-Tyr3-octreotide preparation and administration...
Objective . The aim of this work was to assess robustness and reliability an adaptive thresholding algorithm for the biological target volume estimation incorporating reconstruction parameters. Method In a multicenter study, phantom with spheres different diameters (6.5–57.4 mm) filled 18 F-FDG at target-to-background ratios (TBR: 2.5–70) scanned acquisition periods (2–5 min). Image algorithms were used varying number iterations postreconstruction transaxial smoothing. Optimal thresholds...
Targeted radionuclide therapies in nuclear medicine departments increasingly depend on using unsealed beta radiation sources the labeling of peptides and antibodies. Monitoring doses received by fingers hands during these procedures is best accomplished with TLD dosimeters that can be located at fingertips. The present study examines response two (MCP-Ns GR200A) to 90Sr/90Y, 85Kr, 147Pm. were supplied different services, all irradiations performed PTB Institute Germany. Each dosimetry...
18F-FDG PET/CT imaging allows to study oncological patients and their relative diagnosis through the standardised uptake value (SUV) evaluation. During radiopharmaceutical injection, an extravasation event may occur, making SUV less accurate possibly leading severe tissue damage. The aimed propose a new technique monitor manage these events, provide early evaluation correction estimated coefficient.A cohort of 70 undergoing 18F- FDG examinations was enrolled. Two portable detectors were...