A5065110573- Radiopharmaceutical Chemistry and Applications
- Curcumin's Biomedical Applications
- RNA Interference and Gene Delivery
- Alzheimer's disease research and treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- Medical Imaging Techniques and Applications
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Diet and metabolism studies
- Metal-Organic Frameworks: Synthesis and Applications
- Skin Protection and Aging
- Nonmelanoma Skin Cancer Studies
- Synthesis and biological activity
- Cell Adhesion Molecules Research
- Animal testing and alternatives
- 14-3-3 protein interactions
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Medicinal Plants
- Nuclear Receptors and Signaling
- Radioactive Decay and Measurement Techniques
Azienda Sanitaria Unità Locale di Reggio Emilia
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2024
Ospedale Santa Maria
2013-2017
Santa Maria Nuova Hospital
2017
Santa Maria Nuova Hospital
2015
Curcumin (CUR) and curcuminoids complexes labeled with fluorine-18 or technetium-99m have recently shown their potential as diagnostic tools for Alzheimer's disease. Gallium-68 is a positron-emitting, generator-produced radionuclide, its properties can be exploited in situ medical facilities without cyclotron. Moreover, CUR showed higher uptake tumor cells compared to normal cells, suggesting applications this field. In spite of this, no studies using been performed direction, so far....
We report a simple method for the incorporation of Cu(I) or 64Cu(I) radionuclides in covellite nanocrystals (CuS NCs). After situ reduction Cu(II) 64Cu(II) ions by ascorbic acid, their PEG-coated CuS NCs takes place at room temperature. In all reaction steps, stability under physiological conditions was ensured. The copper could also take on bearing biotin molecules surface, with no detrimental effects specific binding affinity toward streptavidin after incorporation. At low loading Cu ions,...
In spite of the hazard due to radiation exposure, preparation 90 Y- and 177 Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures. present study performance a commercial automatic synthesizer based on disposable cassettes for labelling Lu- Y-DOTA-conjugated biomolecules (namely, DOTATOC PSMA-617) was evaluated compared semiautomated approach. The dose exposure operators as well. More than 300 clinical preparations both have been three different methods. mean...
Curcumin derivatives labelled with fluorine-18 or technetium-99m have recently shown their potential as diagnostic tools for Alzheimer’s disease. Nevertheless, no study by exploiting the labelling gallium-68 has been performed so far, in spite of its suitable properties (positron emitter, generator produced radionuclide). Herein, an evaluation affinity synthetic β-amyloid fibrils and amyloid plaques three nat/68Ga-labelled curcumin analogues, namely (CUR), bis-dehydroxy-curcumin (bDHC)...
Curcumin is known for its therapeutic properties; among these, antioxidant, anti-inflammatory and anti-cancer ones stand out. Besides, curcumin metal complexes have shown widespread application in medicine can be exploited as lead structures developing metal-based drugs. Unfortunately, poorly bioavailable, mainly due to instability physiological conditions; this weakness tightly connected the presence of β-diketo moiety undergoing tautomeric equilibrium. Stability metal-chelating ability...
The use of germanium-68 (⁶⁸Ge)/gallium-68 (⁶⁸Ga) generators is still limited when compared with the ⁹⁹Mo/⁹⁹mTc counterpart, mainly because absence commercial kits and a kit-based method for preparing Ga-labelled radiopharmaceuticals in reliable way. present study aimed to develop optimize direct labelling DOTATOC ⁶⁸Ga through approach.A fraction eluate two different ⁶⁸Ge/⁶⁸Ga was directly injected into vial prefilled precursor, buffer scavenger (the prototype potential lyophilized kit)....
Colorectal cancer is the third most commonly occurring in men and second women worldwide. We have recently reported that curcuminoid complexes labelled with gallium-68 demonstrated preferential uptake HT29 colorectal K562 lymphoma cell lines compared to normal human lymphocytes. In present study, we report a new gallium-68-labelled curcumin derivative (68Ga-DOTA-C21) its initial validation as marker for early detection of cancer. The precursor non-radioactive were synthesized deeply...
Abstract MiRNAs are single stranded RNAs of 18–22 nucleotides. They promising diagnostic and prognostic markers for several pathologies including tumors, neurodegenerative, cardiovascular autoimmune diseases. In the present work development characterization anti-miRNA radiolabeled probes based on peptide nucleic acids (PNAs) potential non-invasive molecular imaging in vivo giant cell arteritis described. MiR-146a miR-146b-5p were selected as targets because they have been found up-regulated...
Abstract Clinical use of topical ascorbic acid solution could have both the role as an adjunct to consolidated therapies and alternative them, for treatment BCC SCC skin.