Local heating can be produced by iron oxide nanoparticles (IONPs) when exposed to an alternating magnetic field (AMF). To measure the temperature profile at nanoparticle surface with a subnanometer resolution, here we present molecular probe based on thermal decomposition of thermo-sensitive molecule, namely, azobis[N-(2-carboxyethyl)-2-methylpropionamidine]. Fluoresceineamine (FA) was bound azo molecule IONP functionalized poly(ethylene glycol) (PEG) spacers different weights. Significant...

Abstract Magnetic hyperthermia (MHT) and photothermal therapy (PTT) are emergent state‐of‐the‐art modalities for thermal treatment of cancer. While their mechanisms action have distinct physical bases, both approaches rely on nanoparticle‐mediated remote onset thermotherapy. Yet, the two heating techniques interchangeable? Here, obtained either with MHT or PTT is compared. The assessed in environments involves a set nanomaterials differing shape (spheres, cubes, stars, shells, rods) as well...

Innovative synthesis routes revolutionized nanomaterial combination and design possibilities resulting in a new generation of fine-tuned nanoparticles featuring exquisite shape constitution control.However, there is still room for improvement when it comes to the development multi-functional nanoparticle agents merging plurality therapeutic functions tackle tumors simultaneously by synergic mechanisms.Herein, we report an optimized nanohybrid cancer tri-therapy maghemite (γ-Fe2O3)...

We present an approach for the synthesis of ternary copper indium sulfide (CIS) and quaternary zinc (CIZS) nanocrystals (NCs) by means partial cation exchange with In3+ Zn2+. The consists a sequential three-step synthesis: first, binary Cu2S NCs were synthesized, followed homogeneous incorporation in situ cation-exchange reaction, leading to CIS NCs. In last step, second was performed where Zn2+ partially replaced Cu+ cations at surface, creating ZnS-rich shell preservation size shape. By...

The use of magnetic nanoparticles in oncothermia has been investigated for decades, but an effective combination and localized chemotherapy under clinical hyperthermia (MH) conditions calls novel platforms. In this study, we have engineered thermoresponsive iron oxide nanocubes (TR-cubes) to merge MH treatment with heat-mediated drug delivery, having mind the translation nanoplatform. We chosen based a cubic shape because their outstanding heat performance conditions, which makes them...

Progress of thermal tumor therapies and their translation into clinical practice are limited by insufficient nanoparticle concentration to release therapeutic heating at the site after systemic administration. Herein, use Janus magneto-plasmonic nanoparticles, made gold nanostars iron oxide nanospheres, as efficient nanoheaters whose on-site delivery can be improved magnetic targeting, is proposed. Single combined magneto- photo-thermal properties nanoparticles render them compelling...

Significance Naturally occurring magnetic nanoparticles have been detected in human cells; however, their origin and role remain unknown. In the present paper, observation of long-term transformations man-made internalized stem cells displays a mechanism regarding assimilation. Indeed, are first degraded by cells, then new synthesized situ from released iron. This “remagnetization” phenomenon is observed under specific pathways only, involves ferritin protein, seems linked to detoxification...

Despite their highly efficient plasmonic properties, gold nanoparticles are currently preferred to silver for biomedical applications such as photothermal therapy due high chemical stability in the biological environment. To confer protection while preserving we allied advantages of both materials and produced hybrid made an anisotropic nanoplate core coated with a frame gold. The efficiency these (Ag@AuNPs) photothermia was compared monometallic nanoplates (AgNPs) or nanostars (AuNPs)....

Herein, we prepare nanohybrids by incorporating iron oxide nanocubes (cubic-IONPs) within a thermoresponsive polymer shell that can act as drug carriers for doxorubicin(doxo). The cubic-shaped nanoparticles employed are at the interface between superparamagnetic and ferromagnetic behavior have an exceptionally high specific absorption rate (SAR), but their functionalization is extremely challenging compared to bare they strongly interact with each other. By conducting grafting reaction using...

The photothermal use of iron oxide magnetic nanoparticles (NPs) is becoming more and popular documented. Herein, we compared the (PT) therapy potential versus hyperthermia (MHT) modality nanospheres, largely used in biomedical field multicore nanoflowers known among best nanoheaters. NPs were imaged using transmission electron microscopy their optical properties characterized by UV-Vis-NIR-I-II before oxidation (magnetite) after to maghemite. efficiency all MHT PT preferred second...

The use of inorganic nanoparticles in biomedicine, particular the field diagnosis and therapy human diseases, has rapidly grown last few decades. Water solubilisation nanoparticles, especially for particles synthesized non-polar solvents, is an essential prerequisite their biological exploitation. encapsulation surfactant coated into polymer shells represents one most suitable popular methods to make them water soluble. Herein we provide overview amphiphilic molecules used efforts undertaken...

Despite efforts in producing nanoparticles with tightly controlled designs and specific physicochemical properties, these can undergo massive nano-bio interactions bioprocessing upon internalization into cells. These transformations generate adverse biological outcomes premature loss of functional efficacy. Hence, understanding the intracellular fate is a necessary prerequisite for their introduction medicine. Among nanomaterials devoted to theranostics copper sulfide (CuS), which provides...

We report a simple method for the incorporation of Cu(I) or 64Cu(I) radionuclides in covellite nanocrystals (CuS NCs). After situ reduction Cu(II) 64Cu(II) ions by ascorbic acid, their PEG-coated CuS NCs takes place at room temperature. In all reaction steps, stability under physiological conditions was ensured. The copper could also take on bearing biotin molecules surface, with no detrimental effects specific binding affinity toward streptavidin after incorporation. At low loading Cu ions,...

A polymer coating with multiple binding sites provides iron oxide nanoparticles protection against intracellular degradation.

The nanoparticles produced by magnetotactic bacteria, called magnetosomes, are made of a magnetite core with high levels crystallinity surrounded lipid bilayer. This organized structure has been developed during the course evolution these organisms to adapt their specific habitat and is assumed resist degradation be able withstand demanding biological environment. Herein, we investigated magnetosomes' structural fate upon internalization in human stem cells using magnetic photothermal...

We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs HeLa–GFP cells. The release via pH-mediated endosomal escape is shown. act first magnetofection agents boost cellular uptake then probes track the mechanism by electron microscopy.

Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on pH. On three different resulting nanocarrier systems, experiments loading release gold nanoparticles as well effective siRNA in vitro delivery human cells performed. Detailed facts importance to specialist readers published ”Supporting Information”....

Carbon Dots (CDs) are innovative materials which have potential applications in many fields, including nanomedicine, energy and catalysis. Here CDs were produced by the alkali-assisted ultrasonic route characterized several techniques to determine their composition properties. Fluorescence nanoscopy using single-molecule localization microscopy shows that they very good photophysical properties a remarkable blinking behaviour at 405 nm. Moreover, these safe material, non-toxic towards...

Magnetic nanoparticles coated with protein-specific molecularly imprinted polymers (MIPs) are receiving increasing attention thanks to their binding abilities, robustness, and easy synthesis compared natural analogues also able target proteins, such as antibodies or aptamers. Acting tailor-made recognition systems, MIPs can be used in many vivo nanomedicine applications, targeted drug delivery, biosensing, tissue engineering. Nonetheless, studies on biocompatibility long-term fate biological...

The combined passive and active targeting of tumoral tissue remains an relevant cancer research field. Here, we exploit the properties two highly magnetic nanomaterials, magnetosomes ultramagnetic liposomes, in order to magnetically target prostate adenocarcinoma tumors, implanted orthotopically or subcutaneously, take into account role tumor vascularization efficiency. Analysis organ biodistribution vivo revealed that, for all conditions, both nanomaterials accumulate mostly liver spleen,...

Merging pH- and thermo-responsive surface properties with intrinsic features of gold–iron oxide heterodimers: example their exploitation for dual loading applications.

Abstract Iron oxide nanoparticles, due to their magnetic properties, are versatile tools for biomedical applications serving both diagnostic and therapeutic roles. Their performance is intricately intertwined with fate in the demanding biological environment. Once inside cells, these nanoparticles can be degraded, implying a loss of efficacy, but also transformed into neo‐synthesized potentially restoring functionality. This study aims delineate features governing processes. Magnetic...