Alice Bergamini
A5060103872- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Reproductive Biology and Fertility
- Gestational Trophoblastic Disease Studies
- PARP inhibition in cancer therapy
- Ovarian function and disorders
- Intraperitoneal and Appendiceal Malignancies
- Prenatal Screening and Diagnostics
- Endometriosis Research and Treatment
- Testicular diseases and treatments
- Uterine Myomas and Treatments
- Sarcoma Diagnosis and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- CAR-T cell therapy research
- Cervical Cancer and HPV Research
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Gynecological conditions and treatments
- Reproductive System and Pregnancy
- Genital Health and Disease
- BRCA gene mutations in cancer
- CRISPR and Genetic Engineering
- Reproductive tract infections research
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2025
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
IRCCS Ospedale San Raffaele
2015-2025
Ospedale Maggiore
2025
San Raffaele University of Rome
2013-2024
University of Milan
2022-2024
Charing Cross Hospital
2023
Mylan (Switzerland)
2019
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2016-2018
The objective of this work is to assess the 5-year outcomes patients undergoing conization for high-grade cervical lesions that simultaneously present as risk factors in persistence HPV infection and positivity surgical resection margins. This a retrospective study evaluating lesions. All included had both positive margins experienced at 6 months. Associations were evaluated with Cox proportional hazard regression summarized using ratio (HR). charts 2966 reviewed. Among whole population, 163...
Background: Cervical dysplasia persistence/recurrence has a great impact on women's health and quality of life. In this study, we investigated whether prognostic nomogram may improve risk assessment after primary conization. Methods: This is retrospective multi-institutional study based charts consecutive patients undergoing conization between 1 January 2010 31 December 2014. A assessing the importance different variables was built. cohort treated 2015 30 June 2016 used to validate nomogram....
Background To date, T cells redirected with CD19-specific chimeric antigen receptors (CAR) have gained impressive success in B-cell malignancies. However, treatment failures are common and the occurrence of severe toxicities, such as cytokine release syndrome (CRS), still limits full exploitation this approach. Therefore, development cell products improved therapeutic indexes is highly demanded. Methods In project, we investigated how CD4 CD8 populations cooperate during CD19 CAR-T responses...
PURPOSE Selinexor inhibits exportin-1 (XPO1) resulting in nuclear accumulation of tumor suppressor proteins including p53 and has clinical activity endometrial cancer (EC). The primary end point was to assess progression-free survival (PFS) with once-weekly oral selinexor patients advanced or recurrent EC. PATIENTS AND METHODS ENGOT-EN5/GOG-3055/SIENDO a randomized, prospective, multicenter, double-blind, placebo-controlled, phase III study at 107 sites 10 countries. Patients 18 years older...
Purpose Platinum-based chemotherapy (PBC) for patients with progressing ovarian cancer (OC) is more effective a longer time interval from previous platinum treatment (platinum-free [PFI]). In 1999, it was hypothesized that prolonging PFI single-agent non-PBC (NPBC) may offer strategy to improve overall outcome. MITO-8 aimed verify this hypothesis commonly used in clinical practice although has not been prospectively tested. Methods an open-label, prospective, randomized, superiority trial....
Fertility issues have become critical in the management and counseling of BRCA mutation carriers. In this setting four points deserve consideration. (1) Women general lose their ability to conceive at a mean age 41 years, thus suggested policy prophylactic bilateral salpingo-oophorectomy 40 for carriers does not affect chances natural pregnancy. Conversely, if procedure is chosen 35 years old, oocyte cryopreservation prior surgery should be considered. (2) Some evidence suggests that ovarian...
Background: Primary prevention through vaccination is a prophylactic approach aiming to reduce the risk of developing human papillomavirus (HPV)-related lesions. No mature and long-term data supported adoption in women undergoing conization. Methods: This retrospective multi-institutional study. Charts consecutive patients conization between 2010 2014 were collected. All included had at least 5 years follow-up. We compared outcomes plus alone. A propensity-score matching algorithm was...
The assessment of deep myometrial invasion (MI) and lymph node involvement is utmost importance in the preoperative staging endometrial cancer (EC). Imaging parameters derived respectively from MRI PET have shown good predictive value. main aim present study to assess diagnostic performance hybrid 18F-FDG PET/MRI EC staging, with particular focus on MI lymphnodal detection.Prospective monocentric including 35 patients biopsy-proven undergoing (December 2018-March 2021) for purpose....