Michal Zikán
A5072204852- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Health, Environment, Cognitive Aging
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Nutrition, Genetics, and Disease
- Cancer Genomics and Diagnostics
- Beetle Biology and Toxicology Studies
- Intraperitoneal and Appendiceal Malignancies
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Lymphatic Disorders and Treatments
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- CRISPR and Genetic Engineering
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- Multiple and Secondary Primary Cancers
Charles University
2016-2025
Fakultní nemocnice Bulovka
2018-2025
General University Hospital in Prague
2010-2022
Creative Commons
2022
University Hospital Kralovske Vinohrady
2021
Masaryk University
2019
Ocní klinika
2008-2016
Georgetown University
2010
Centre Léon Bérard
2010
City Of Hope National Medical Center
2010
PURPOSE Tissue factor is highly expressed in cervical carcinoma and can be targeted by tisotumab vedotin (TV), an antibody-drug conjugate. This phase Ib/II study evaluated TV combination with bevacizumab, pembrolizumab, or carboplatin for recurrent metastatic cancer (r/mCC). METHODS open-label, multicenter (ClinicalTrials.gov identifier: NCT03786081 ) included dose-escalation arms that assessed dose-limiting toxicities (DLTs) identified the recommended II dose (RP2D) of bevacizumab (arm A),...
Abstract Tobacco use is a major modifiable risk factor for adverse health outcomes, including cancer, and elicits profound epigenetic changes thought to be associated with long-term cancer risk. While electronic cigarettes (e-cigarettes) have been advocated as harm reduction alternatives tobacco products, recent studies revealed potential detrimental effects, highlighting the urgent need further research into molecular impacts of e-cigarettes. Here, we applied computational deconvolution...
Abstract The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of for BRCA1 or BRCA2 mutation carriers. We evaluated the associations 3 additional single nucleotide (SNPs), rs4973768 SLC4A7/NEK10, rs6504950 STXBP4/COX11, rs10941679 at 5p12, reanalyzed previous using carriers a sample 12,525 7,409 Additionally, we investigated potential interactions between SNPs assessed implications risk prediction. minor alleles were...
Background Endometrial cancer incidence is continuing to rise in the wake of current ageing and obesity epidemics. Much risk for endometrial development influenced by environment lifestyle. Accumulating evidence suggests that epigenome serves as interface between genome hypermethylation stem cell polycomb group target genes an epigenetic hallmark cancer. The objective this study was determine functional role factors development. Methods Findings Epigenome-wide methylation analysis >27,000...
Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains significant challenge. Aberrant methylation patterns linked CpGs analyzed DNA fragments shed by cancers into bloodstream (i.e. cell-free DNA) can provide highly specific signals indicating presence. We 699 cancerous and non-cancerous tissues using array or reduced representation bisulfite sequencing discover most OC patterns. A three-DNA-methylation-serum-marker...
Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of changes in human carcinogenesis remain largely unexplored. Moreover, role for prediction clinical outcome still uncertain and confined to specific cancers. Here we perform most comprehensive study throughout carcinogenesis, analysing 27,578 CpGs each 1,475 samples, ranging from normal cells advance non-invasive neoplastic transformation invasive cancers metastatic tissue. We demonstrate that hypermethylation at...
The vast majority of epithelial ovarian cancer arises from tissues that are embryologically derived the Müllerian Duct. Here, we demonstrate a DNA methylation signature in easy-to-access Duct-derived cervical cells women with and without (i.e. referred to as Women's risk IDentification for Ovarian Cancer index or WID-OC-index) is capable identifying an absence tumour AUC 0.76 endometrial 0.81. This observation cell WID-OC-index mimics epigenetic program those at becoming cancerous BRCA1/2...
PURPOSE Selinexor inhibits exportin-1 (XPO1) resulting in nuclear accumulation of tumor suppressor proteins including p53 and has clinical activity endometrial cancer (EC). The primary end point was to assess progression-free survival (PFS) with once-weekly oral selinexor patients advanced or recurrent EC. PATIENTS AND METHODS ENGOT-EN5/GOG-3055/SIENDO a randomized, prospective, multicenter, double-blind, placebo-controlled, phase III study at 107 sites 10 countries. Patients 18 years older...
Background Second-line treatment options for persistent, recurrent or metastatic (r/m) cervical cancer are limited. We investigated the safety, efficacy, and immunogenicity of therapeutic DNA-based vaccine VB10.16 combined with immune checkpoint inhibitor atezolizumab in patients human papillomavirus (HPV)16-positive r/m cancer. Patients methods This multicenter, single-arm, phase 2a study ( NCT04405349 , registered 26 May 2020) enrolled adult HPV16-positive received 3 mg (every weeks (Q3W)...
The goal of this study was to determine the sensitivity, specificity, and accuracy transrectal ultrasound (TRUS) in comparison magnetic resonance imaging (MRI) evaluation tumor volume, early parametrial infiltration, identification residual early-stage cervical cancer. Patients whom an cancer diagnosed by clinical examination were enrolled study. Only those patients who examined both MRI TRUS with following surgical treatment included. Imaging results compared pathology findings. Altogether,...
Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased risks in the general population. In a previous study, we demonstrated minor alleles at three these SNPs, FGFR2, TNRC9 and MAP3K1, also confer for BRCA1 or BRCA2 mutation carriers. Three additional SNPs rs3817198 LSP1, rs13387042 2q35 rs13281615 8q24 since been reported to be population, this study evaluated their risk 9442 5665 carriers from 33...