A5067939058- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Bacterial Infections and Vaccines
- Cerebrospinal fluid and hydrocephalus
- Infectious Diseases and Tuberculosis
- Cerebrovascular and genetic disorders
- Acute Ischemic Stroke Management
- Streptococcal Infections and Treatments
- Neurobiology of Language and Bilingualism
- Neurological Disease Mechanisms and Treatments
- Otolaryngology and Infectious Diseases
- Epilepsy research and treatment
Oslo University Hospital
2019-2024
University of Oslo
2019-2023
Smerteklinikken
2019-2020
University of Oxford
2019-2020
Background Alzheimer's disease (AD) remains a clinical diagnosis but biomarkers from cerebrospinal fluid (CSF) and more lately amyloid imaging with positron emission tomography (PET), are important to support of AD. Objective To compare amyloid-β (Aβ) PET in CSF evaluate the prediction Aβ on memory clinic setting. Methods We included 64 patients who had lumbar puncture 18F-Flutemetamol performed within 190 days. was binary classified (Flut+ or Flut-) logistic regression analyses for...
Abstract Background Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI unclear. We hypothesize that deposition, measured Flutemetamol ( 18 F-Flut) positron emission tomography (PET), common seven-year survivors diagnosed and, further, quantitatively assessed F-Flut-PET uptake 7 years correlates amyloid-β peptide (Aβ 42 ) levels cerebrospinal fluid (CSF) at 1 year, measures neurodegeneration...
18F-flutemetamol positron emission tomography (PET) is used to assess cortical amyloid-β burden in patients with cognitive impairment support a clinical diagnosis. Visual classification the most widely method practice although semi-quantification beneficial obtain an objective and continuous measure of Aβ burden. The aims were: first evaluate correspondence between standardized uptake value ratios (SUVRs) from three different software, Centiloids visual classification, second estimate...
Abstract Background and purpose β‐Amyloid formation has been suggested to form part of the brain's response bacterial infection. This hypothesis based on experimental animal studies autopsy in humans. We asked if β‐amyloid accumulates locally around a brain abscess living human patients. Furthermore, because patients may suffer from chronic cognitive symptoms after treatment, we also precipitates accumulation neocortex manner that could explain abscess‐related complaints. Methods In...
BACKGROUND AND OBJECTIVES: A bacterial brain abscess is an emergency and should be drained of pus within 24 hours diagnosis, as recently recommended. In this cross-sectional study, we investigated whether delaying drainage entails expansion what the underlying mechanism might be. METHODS: Repeated MRI 47 patients who did not undergo immediate drainage, osmolarity measurements, immunocytochemistry, proteomics, 18 F-fluorodeoxyglucose positron emission tomography. RESULTS: Time from first to...
Background: Patients with Alzheimer’s disease (AD) show heterogeneity in clinical progression rate, and we have limited tools to predict prognosis. Amyloid burden from 18F-Flutemetamol positron emission tomography (PET), as measured by standardized uptake value ratios (SUVR), might provide prognostic information. Objective: We investigate whether PET composite or regional SUVRs are associated trajectories of progression. Methods: This observational longitudinal study included 94 patients AD....
Bacterial brain abscesses may have long-term clinical consequences, eg, mental fatigue or epilepsy, but structural consequences to the remain underexplored. We asked if damage activity long term, extent of such depends on size abscess, and abscess capsule, which is often left in place during neurosurgery, remains a site inflammation, could explain long-lasting symptoms patients with abscess.
Neurodegenerative dementia may, in rare cases, initially manifest as isolated language impairments the absence of other cognitive symptoms. These are often somewhat imprecisely referred to difficulties with 'word finding'. There several variants this form dementia, each caused by different underlying neuropathologies. Occasionally problems speech rather than predominate. Patients may have exclusively or speech-related symptoms for years, but eventually all will progress generalised dementia....
Abstract Background Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI unclear. We hypothesize that deposition, measured Flutemetamol ( 18 F-Flut) positron emission tomography (PET), common 7-year survivors diagnosed and, further, quantitatively assessed F-Flut-PET uptake seven years correlates amyloid-β peptide (Aβ 42 ) levels cerebrospinal fluid (CSF) at one year, measures neurodegeneration...
Abstract Background: Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI unclear. We hypothesize that deposition, measured Flutemetamol ( 18 F-Flut) positron emission tomography (PET), common 7-year survivors diagnosed and, further, quantitatively assessed F-Flut-PET uptake seven years correlates amyloid-β peptide (Aβ₄₂) levels cerebrospinal fluid (CSF) at one year, measures neurodegeneration...
Abstract Background: Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI unclear. We hypothesize that deposition, measured Flutemetamol ( 18 F-Flut) positron emission tomography (PET), common seven-year survivors diagnosed and, further, quantitatively assessed F-Flut-PET uptake seven years correlates amyloid-β peptide (Aβ₄₂) levels cerebrospinal fluid (CSF) at one year, measures...
Abstract Background: Cognitive impairment (CI) with mixed vascular and neurodegenerative pathologies after stroke is common. The role of amyloid pathology in post-stroke CI unclear. We hypothesize that deposition, measured Flutemetamol ( 18 F-Flut) positron emission tomography (PET), common 7-year survivors diagnosed and, further, quantitatively assessed F-Flut-PET uptake seven years correlates amyloid-β peptide (Aβ₄₂) levels cerebrospinal fluid (CSF) at one year, measures neurodegeneration...