A5014814742- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Protease and Inhibitor Mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- Cholesterol and Lipid Metabolism
- Complement system in diseases
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Fatty Acid Research and Health
- Platelet Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Blood Coagulation and Thrombosis Mechanisms
- PARP inhibition in cancer therapy
- Immune Cell Function and Interaction
- RNA regulation and disease
- Inflammasome and immune disorders
- Calpain Protease Function and Regulation
- Endoplasmic Reticulum Stress and Disease
- Chemokine receptors and signaling
- Sirtuins and Resveratrol in Medicine
- Drug Transport and Resistance Mechanisms
- Gut microbiota and health
- Lipoproteins and Cardiovascular Health
- Heparin-Induced Thrombocytopenia and Thrombosis
Oslo University Hospital
2016-2025
University of Oslo
2010-2022
Maastricht University
2015-2017
Universidad Pablo de Olavide
2017
Universidad de Sevilla
2017
University of Debrecen
2017
Ludwig-Maximilians-Universität München
2017
Instituto de la Grasa
2017
Background and Purpose— Interleukin (IL)-23 is a cytokine in the IL-12 family, mainly produced by antigen-presenting cells with central role inflammation. We hypothesize that IL-23 also important atherogenesis investigate this population carotid atherosclerosis. Methods— Plasma levels of were measured patients artery stenosis healthy controls. The mRNA its receptor, IL-23R, atherosclerotic plaques, nonatherosclerotic vessels, peripheral blood mononuclear cells, plasmacytoid dendritic cells....
Abstract Aims We recently reported five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) 7–10 days after receiving the first dose ChAdOx1 nCoV-19 adenoviral vector vaccine against corona virus disease 2019 (COVID-19). aimed to investigate pathogenic immunological responses operating in these patients. Methods and results assessed circulating inflammatory markers by assays cell phenotyping flow cytometry analyses performed immunoprecipitation with anti-platelet factor (PF)4...
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically alternative complement pathway, is activated in patients with carotid atherosclerosis related adverse outcome these patients, are scarce. Methods Results We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), H advanced a Discovery (n=324) Validation (n=206) cohort relation (mean follow‐up 7.8 6.6 years, respectively). Our major...
Background Atherosclerosis is a major cause of cerebrovascular disease. Matrix metalloproteinases (MMPs) play an important role in matrix degradation within the atherosclerotic lesion leading to plaque destabilization and ischemic stroke. We hypothesized that MMP-7 could be involved this process. Methods Plasma levels were measured 182 consecutive patients with moderate (50–69%) or severe (≥70%) internal carotid artery stenosis, 23 healthy controls. The mRNA plaques different symptomatology,...
BackgroundDuring atherogenesis, cholesterol precipitates into crystals (CC) in the vessel wall, which trigger plaque inflammation by activating NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome. We investigated relationship between CC, complement NLRP3 patients with cardiovascular disease.MethodsWe analysed plasma, peripheral blood mononuclear cells (PBMC) carotid plaques from advanced atherosclerosis applying ELISAs, multiplex cytokine assay, qPCR, immunohistochemistry,...
Background and Purpose Fatty acid binding protein 4 (FABP4) has been shown to play an important role in macrophage cholesterol trafficking associated inflammation. To further elucidate the of FABP4 atherogenesis humans, we examined regulation carotid atherosclerosis ischemic stroke. Methods We plasma levels asymptomatic (n = 28) symptomatic 31) patients with atherosclerosis, as well 202 subjects acute In a subgroup also analysed expression within atherosclerotic lesion. addition,...
Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) has been shown to be increased in patients with acute ischemic stroke. Here, we evaluated plasma sLOX-1 levels and vascular carotid plaque LOX-1 (ie, OLR1) gene expression stroke transient attack (TIA) particular focus on their relation time since symptom onset.Plasma (n=232) OLR1 (n=146) were who referred evaluation for endarterectomy, as well healthy control (n=81). Patients categorized according presence of or (n=35)...
More than 170 post-transcriptional RNA modifications regulate the localization, processing and function of cellular RNAs, aberrant have been linked to a range human diseases. The modification landscape in atherosclerosis, main underlying cause cardiovascular diseases, is still largely unknown.We used mass spectrometry analyse selection RNA-modifying enzymes N6-methyladenosine (m6A) carotid atherosclerotic lesion samples representing early advanced stages atherosclerosis as compared...
Objective Atherosclerosis is a chronic inflammatory disorder that involves range of mediators. Although interleukin (IL)-9 has been related to inflammation, there are at present no data on its role in atherosclerosis. Here we have examined IL-9 and receptor (IL-9R) systemically locally patients with coronary carotid Methods Plasma was quantified by enzyme immunoassay multiplex technology. IL-9R mRNA were real-time RT-PCR, their localization within the lesion assessed immunohistochemistry....
Fish consumption is considered health beneficial as it decreases cardiovascular disease (CVD)-risk through effects on plasma lipids and inflammation. We investigated a salmon protein hydrolysate (SPH) that hypothesized to influence lipid metabolism have anti-atherosclerotic anti-inflammatory properties. 24 female apolipoprotein (apo) E(-/-) mice were divided into two groups fed high-fat diet with or without 5% (w/w) SPH for 12 weeks. The atherosclerotic plaque area in aortic sinus arch,...
Abstract Cholesterol crystals (CC) play an essential role in the formation of atherosclerotic plaques. CC activate classical and alternative complement pathways, but lectin pathway is unknown. We hypothesized that pattern recognition molecules (PRMs) from bind function as upstream innate inflammatory signal pathophysiology atherosclerosis. investigated binding PRMs mannose-binding (MBL), ficolin-1, ficolin-2, ficolin-3, associated serine proteases, activation products to vitro using...
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), rate limiting enzyme in salvage pathway adenine dinucleotide (NAD)+ generation, atherogenesis is largely unknown. Here we investigated effects iNAMPT overexpression leukocytes on inflammation atherosclerosis.Low-density lipoprotein receptor-deficient mice with hematopoietic human (iNAMPThi), a western type diet, showed...
AimsThe homeostatic chemokines, CCL19 and CCL21 their receptor CCR7, have recently been linked to atherogenesis. We investigated the expression of CCL19/CCL21/CCR7 in carotid atherosclerosis as well ability these chemokines modulate lipid accumulation macrophages vascular smooth muscle cell (SMC) phenotype.
Changes in brain stiffness can be an important biomarker for neurological disease. Magnetic resonance elastography (MRE) quantifies tissue stiffness, but the results vary between acquisition and reconstruction methods.To measure MRE repeatability estimate effect of different methods varying data quality on estimated stiffness.Prospective.Fifteen healthy subjects.3T MRI, gradient-echo sequence with a 50 Hz vibration frequency.Imaging was performed twice each subject. Images were reconstructed...
Acute myocardial infarction (MI) results in tissue damage to affected areas of the myocardium. The initial inflammatory response is most damaging for residual cardiac function, while at later stages inflammation a prerequisite proper healing and scar formation. Balancing extent duration during various after MI thus pivotal preserving function. Recently, signaling lymphocytic activation molecule 1 (SLAMF1)-derived peptide (P7) was shown reduce secretion cytokines protected against acute...
Atherosclerosis is a progressive chronic disease, in which inflammation plays key role. The calcium-binding proteins calgranulins including S100A8, S100A9, and S100A12 are involved many cellular activities pathological processes inflammation. We therefore hypothesized that may be markers of plaque instability patients with carotid atherosclerosis.Plasma levels S100A8/A9 S100A10 were measured 159 consecutive high-grade stenosis 22 healthy control subjects. mRNA also within the atherosclerotic...
Aim Interleukin-27 (IL-27) is involved in different inflammatory diseases; however, its role atherosclerosis unclear. In this study we investigated the expression of IL-27 and receptor patients with carotid if could modulate effects NLRP3 inflammasome vitro. Methods Plasma was measured by enzyme immunoassay stenosis (n = 140) healthy controls 19). Expression IL-27R analyzed quantitative PCR immunohistochemistry plaques from non-atherosclerotic vessels. THP-1 monocytes, primary monocytes...