A5086716304- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Food composition and properties
- Edible Oils Quality and Analysis
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Antioxidant Activity and Oxidative Stress
- Peroxisome Proliferator-Activated Receptors
- Immune cells in cancer
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Phytochemicals and Antioxidant Activities
- Bone Metabolism and Diseases
- Immune Cell Function and Interaction
- Lipid metabolism and biosynthesis
- Bone health and treatments
- Polysaccharides Composition and Applications
- Lipoproteins and Cardiovascular Health
- GDF15 and Related Biomarkers
- Microbial Metabolites in Food Biotechnology
- Neuroinflammation and Neurodegeneration Mechanisms
- Macrophage Migration Inhibitory Factor
Instituto de la Grasa
2013-2023
Consejo Superior de Investigaciones Científicas
2001-2022
University of Calabar
1997-2022
Universidad Pablo de Olavide
2017-2021
Maastricht University
2017
Universidad de Sevilla
2017
Oslo University Hospital
2017
University of Debrecen
2017
Ludwig-Maximilians-Universität München
2017
University of Oslo
2017
Growth differentiation factor (GDF) 15 is a member of the transforming growth β (TGF-β) superfamily, which operates in acute phase responses through currently unknown receptor. Elevated GDF-15 serum levels were recently identified as risk for coronary syndromes. We show that expression up-regulated disease progresses murine atherosclerosis and primarily colocalizes with plaque macrophages. Hematopoietic deficiency low density lipoprotein receptor−/− mice led to impaired initial lesion...
Objectives— Patients with mutations in the proprotein convertase subtilisin/kexin type 9 ( PCSK9 ) gene have hypercholesterolemia and are at high risk of adverse cardiovascular events. We aimed to stably express pathological human D374Y gain-of-function mutant form DY adult wild-type mice generate a hyperlipidemic proatherogenic animal model, achieved single systemic injection adeno-associated virus (AAV). Approach Results— constructed an AAV-based vector support targeted transfer liver....
The aim of this study was to determine whether isorhamnetin, an immediate 3′-O-methylated metabolite quercetin, affects proliferation, cell death, and the cycle human colon carcinoma (HCT-116) cells. Isorhamnetin found be a potent antiproliferative agent in dose- time-dependent manner, with IC50 72 μM after 48 h incubation as estimated by MTT assay. Flow cytometry fluorescence microscopy analysis showed that isorhamnetin exerted stimulatory effect on apoptosis necrosis. also increased number...
Low- and intermediate-molecular-weight polyphenols are usually extracted by using different solvents (e.g. water, methanol, aqueous acetone). The aim of the present work was to study possible effects some extractable (EPP) on fat protein digestibilities colonic microflora. Degradability these compounds through intestinal tract also studied. Catechin tannic acid (TA) were chosen as representatives most common basic structures EPP (flavonoids gallic respectively). Three groups eight male...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolyphenols as dietary fiber associated compounds. Comparative study on in vivo and vitro propertiesLaura Bravo, Rocio Abia, Fulgencio Saura-CalixtoCite this: J. Agric. Food Chem. 1994, 42, 7, 1481–1487Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/jf00043a017https://doi.org/10.1021/jf00043a017research-articleACS PublicationsRequest reuse...
Postprandial triglyceride-rich lipoproteins (TRL) have a direct effect on vascular smooth muscle cells (SMC) and they increase the risk of atherogenesis. Here, we tested hypothesis that different fatty acid composition TRL is capable differentially modifying gene expression in human coronary artery SMC (CASMC). In addition, cell proliferation transcription factor activation was also evaluated.TRL were prepared from plasma healthy volunteers after ingestion meals enriched refined olive oil...
Novel biological activities for tyrosol metabolites on human endothelial cells.
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), rate limiting enzyme in salvage pathway adenine dinucleotide (NAD)+ generation, atherogenesis is largely unknown. Here we investigated effects iNAMPT overexpression leukocytes on inflammation atherosclerosis.Low-density lipoprotein receptor-deficient mice with hematopoietic human (iNAMPThi), a western type diet, showed...
Stroke is one of the leading causes death worldwide and while there increasing evidence that a Mediterranean diet might decrease risk stroke, effects dietary fat composition on stroke outcomes have not been fully explored. We hypothesize brain damage provoked by would be different depending source fat. To test this, male C57BL/6J mice were fed for 4 weeks with standard low-fat (LFD), high-fat (HFD) rich in saturated fatty acids (HFD-SFA), an HFD containing monounsaturated (MUFAs) from olive...
High postprandial levels of TAG may further induce endothelial dysfunction and inflammation in subjects with high fasting TAG, an effect that seems to be related oxidative stress. The present study investigated whether minor compounds olive oil antioxidant activity decrease soluble isoforms intercellular adhesion molecule 1 (sICAM-1) vascular cell (sVCAM-1), as surrogate markers inflammation, after a high-fat meal. A randomized crossover blind trial on fourteen healthy...
Dietary fatty acids play a role in glucose homeostasis. The aim of this study was to assess the individual relationship between dietary saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) with postprandial β-cell function insulin sensitivity subjects normal high fasting triglycerides. We assessed (by insulinogenic index ratio areas under time–concentration curve) oral minimal model indices) over four nonconsecutive, randomly assigned, high-fat meals containing panel SFA...