A5072747894- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Fatty Acid Research and Health
- Nutritional Studies and Diet
- Cholesterol and Lipid Metabolism
- Genetic factors in colorectal cancer
- Diet and metabolism studies
- Hormonal Regulation and Hypertension
- Lipid metabolism and disorders
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Disease and Adiposity
- Pharmaceutical Economics and Policy
- Edible Oils Quality and Analysis
- Bone Tumor Diagnosis and Treatments
- Consumer Attitudes and Food Labeling
- Diet, Metabolism, and Disease
- Spine and Intervertebral Disc Pathology
- Cytokine Signaling Pathways and Interactions
- Nutrition, Genetics, and Disease
- Dental materials and restorations
- Intracranial Aneurysms: Treatment and Complications
- Sarcoma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
Universidad de Alcalá
2025
Universidade Estadual de Montes Claros
2024
Fundação Faculdade de Odontologia
2023
Fundación General
2016
Hospital Universitario Fundación Jiménez Díaz
2001-2014
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2012
University College London
2012
Medical University of Graz
2012
Leiden University Medical Center
2012
Institute of Cardiology
2012
Background/Objectives: Approximately 30% of women experience pelvic pain one year after vaginal delivery, and this increases to 50% during intercourse. Multimodal physiotherapy is the first-line treatment for myofascial floor muscles (PFM), often incorporating emerging technologies like radiofrequency, despite limited evidence supporting its use. The RASDOP study aims (i) evaluate effectiveness multimodal combining therapeutic education, PFM training, syndrome (MPS) management with or...
The National Cholesterol Education Program (NCEP) has recommended that dietary total fat, saturated and cholesterol intake be reduced to
Forty-two healthy men and women were subjected to four consecutive dietary periods differing in the fat content of saturated fatty acids (SFAs), monounsaturated (MUFAs), polyunsaturated (n-6) [PUFA(n-6)] (n-3) [PUFA(n-3)]. Plasma lipids, vitamin E, vitro LDL oxidation examined during each period. Adhesion human monocytes cultured endothelial cells was used as a functional test identify differences biological properties from Consumption an SFA-rich diet resulted higher cholesterol (4.06±0.85...
The National Cholesterol Education Program (NCEP) recommends that dietary total fat, saturated and cholesterol intake be reduced to < or = 30% of calories, 10% 300 mg/d, respectively (step 1 diet), in the general population reduce plasma low-density lipoprotein (LDL-C) levels heart disease risk. We examined LDL-C-lowering response such a diet (26% 8% 201 mg/d cholesterol) compared with an average American (39% 15% 435 mg cholesterol/d) 153 subjects using periods 4 through 24 weeks for...
The effects of dietary fat saturation on eicosanoid urinary excretion, platelet aggregation (PA) and blood pressure (BP) were studied in 42 healthy subjects. They consumed four consecutive diets differing their [saturated (SFA); monounsaturated (MUFA); polyunsaturated n ‐6 (PUFA ‐6); ‐6/ ‐3, ‐3)]. Each diet period lasted 5 weeks. There no differences 24‐h 2,3‐dinor‐6‐keto‐prostaglandin F 1α excretion among periods. A significant effect was noted regarding the 11‐dehydro‐thromboxane B 2 ( P...
Objectives: This study describes health-related quality of life (HRQL) in a large sample molecularly defined familial hypercholesterolemia (FH) patients compared with unaffected relatives. Study design and setting: Cross-sectional cases recruited the Spanish FH cohort study. A total 1947 subjects ≥18 years were included—1321 626 HRQL was assessed by 12-Item Short-Form Health Survey questionnaire. Main outcomes as follows: Self-perceived health, physical summary component, mental component...
Treatment with selective oestrogen receptor modulators (SERMs) reduces low-density lipoprotein (LDL) cholesterol levels. We assessed the effect of tamoxifen, raloxifene and toremifene their combinations lovastatin on LDL activity in lymphocytes from normolipidaemic familial hypercholesterolaemic (FH) subjects, human HepG2 hepatocytes MOLT-4 lymphoblasts.Lymphocytes were isolated peripheral blood, treated different compounds, 1,1'-dioctadecyl-3,3,3,3'-tetramethylindocarbocyanine perchlorate...
High-density lipoproteins (HDLs) induce prostacyclin (PGI2) release in vascular smooth muscle cells (VSMCs) by up-regulation of cyclooxygenase-2 (Cox-2). Our goal was to analyze the role human HDL lipid moiety on Cox-2-dependent PGI2 synthesis VSMCs and assess impact that intake diets with different fatty acid composition exert HDL-induced release.Human were treated or acids presence absence cell signalling inhibitors (by enzyme immunoassay) Cox-2 protein levels Western blot) analyzed....
Familial hypercholesterolemia is a genetic disorder caused by mutations in the LDL receptor gene. During survey of gene Spanish FH patients we found two same allele: missense N543H mutation exon 11 and 9bp inframe deletion (2393del9) located 17. This double mutant allele was founded 10 out 458 unrelated patients: one homozygous [N543H+2393del9] + [N543H+2393del9], compound heterozygote [W-18X+E256K] 8 heterozygotes. Flow cytometric analysis showed defective binding (20% normal value)...
To derive an estimate for increased cardiovascular (CV) risk in familial hypercholesterolemia (FH) patients use economic analyses. A literature search reporting CV risk, rates, odds or ratios of mortality and morbidity FH was undertaken 2004-2014 reviewing registries, PubMed reference citations. Papers were assessed bias using Newcastle-Ottawa scale. The literature-based relative (RR) calculated. validate the RR, a 10-year baseline events estimated Rutherford-2 clinical trial population. RR...