A5048380224- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Obesity, Physical Activity, Diet
- Vitamin D Research Studies
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Thyroid Disorders and Treatments
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Cystic Fibrosis Research Advances
- Health and Lifestyle Studies
- Atherosclerosis and Cardiovascular Diseases
- Diabetes Treatment and Management
- Muscle metabolism and nutrition
- Antioxidant Activity and Oxidative Stress
- Diabetes Management and Education
- Genetic Associations and Epidemiology
Universidad de Málaga
2008-2022
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2012-2021
Instituto de Investigación Biomédica de Málaga
2012-2021
Instituto de Salud Carlos III
2012-2021
Hospital Regional Universitario de Málaga
2009-2021
Hospital Universitario Rey Juan Carlos
2003-2020
Centro de Investigación Biomédica en Red
2008-2017
Sociedad Española de Endocrinología y Nutrición
2007-2014
Hospital Doctor José Molina Orosa
2003-2013
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2009-2013
The Di@bet.es Study is the first national study in Spain to examine prevalence of diabetes and impaired glucose regulation. A population-based, cross-sectional, cluster sampling was carried out, with target population being entire Spanish population. Five thousand seventy-two participants 100 clusters (health centres or equivalent each region) were randomly selected a probability proportional size. Participation rate 55.8%. variables clinical demographic structured survey, lifestyle physical...
A recent study using a rat model found significant differences at the time of diabetes onset in bacterial communities responsible for type 1 modulation. We hypothesized that humans could also be linked to specific gut microbiota. Our aim was quantify and evaluate difference composition microbiota between children with healthy determine possible relationship glycemic level.A case-control carried out 16 children. The fecal bacteria investigated by polymerase chain reaction-denaturing gradient...
Prospective longitudinal studies evaluating the relevance of "Metabolically Healthy but Obese" (MHO) phenotype at risk for type 2 diabetes mellitus (T2D) and cardiovascular diseases are few results contradictory.As a representative general population, 1051 individuals were evaluated in 1997-1998 re-evaluated after 6 years 11 years. Subjects without known T2D given an oral glucose tolerance test. Anthropometric biochemical variables measured. Four sets criteria considered to define MHO...
Background: Transsexual persons afford a very suitable model to study the effect of sex steroids on uric acid metabolism. Design:This was prospective evaluate levels and fractional excretion (FEUA) in cohort 69 healthy transsexual persons, 22 male-to-female transsexuals (MFTs) 47 female-to-male (FMTs).The subjects were studied at baseline 1 2 yr after starting cross-sex hormone treatment. Results:The higher MFT group.Compared with baseline, had fallen significantly therapy group risen FMT...
Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target Spanish population. In total 5072 people older than 18 years,were randomly selected all over Spain). Socio-demographic and clinical data, survey on habits (physical activity food consumption) weight, height, waist, hip blood pressure were recorder. A fasting draw an oral glucose tolerance test performed. Determinations serum made. follow-up same...
Low physical activity (PA), or sedentary lifestyle, is associated with the development of several chronic diseases. We aimed to investigate current prevalence sedentariness and its association diabetes other cardiovascular risk factors. PA was evaluated in a population-based, cross-sectional, randomly sampled study conducted 2009–2010 Spain. International Physical Activity Questionnaire (SF-IPAQ) used assess PA. 4991 individuals (median age 50 years, 57% women) were studied. Prevalence 32.3%...
The aim of this study was to investigate the national prevalence thyroid dysfunction in Spain and its association with various clinical, environmental, demographic variables.The included 4554 subjects (42.4% men) a mean age 50 years (range 18-93 years), who were participants national, cross-sectional, population-based survey conducted 2009-2010. Data gathered clinical characteristics, physical examination, blood sampling. Thyrotropin, free thyroxine, triiodothyronine, peroxidase antibody...
In the last years, epigenetic processes have emerged as a promising area of complex diseases research. DNA methylation measured in Long Interspersed Nucleotide Element 1 (LINE-1) sequences has been considered surrogate marker for global genome methylation. New findings suggested potential involvement mechanisms Type 2 diabetes (T2DM) crucial interface between effects genetic predisposition and environmental influences. Our study evaluated whether predicted increased risk from T2DM or other...
Abstract Background Few European studies have used an oral glucose tolerance test (OGTT) to examine the incidence of type 2 diabetes. We determined impaired fasting (IFG), (IGT) and diabetes in a population from southern Spain. Material methods A population‐based cohort study was undertaken Pizarra, Baseline data were recorded on age, sex, weight, height, waist hip circumferences, status for 1051 persons, whom 910 free (at‐risk sample). Of these, 714 completed 6‐year follow‐up study. Body...
Eur J Clin Invest 2011; 41 (11): 1202–1209 Background Different studies, mostly cross-sectional, have found an association between low levels of thyroid hormones, even within the normal range, and a greater body mass index. The aim this study was to determine function risk for obesity. Materials methods In population-based prospective study, measurements were made anthropometric parameters, hormone urinary iodine in cohort Pizarra Study (n = 937), repeated 6 years later 784). At second...
Animal studies have revealed the association between stearoyl-CoA desaturase 1 (SCD1) and obesity insulin resistance. However, only a few been undertaken in humans. We studied SCD1 visceral adipose tissue (VAT) subcutaneous (SAT) from morbidly obese patients their with resistance, sterol regulatory element binding protein-1 (SREBP-1) ATPase p97, proteins involved synthesis degradation. The resistance was calculated 40 11 overweight controls. Measurements were made of VAT SAT SCD1, SREBP-1...