A5041800929- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes and associated disorders
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Thyroid Disorders and Treatments
- Diabetes Management and Education
- Parathyroid Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Nutritional Studies and Diet
- Thyroid Cancer Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Diet, Metabolism, and Disease
- Health Systems, Economic Evaluations, Quality of Life
- Blood Pressure and Hypertension Studies
- Pharmacology and Obesity Treatment
- Pancreatic function and diabetes
BioCruces Health research Institute
2016-2024
Centre for Biomedical Network Research on Rare Diseases
2008-2024
University of the Basque Country
2011-2024
Hospital de Cruces
2014-2023
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2014-2023
Instituto de Salud Carlos III
2008-2023
Instituto de Investigación de Enfermedades Raras
2019-2023
Centro de Investigación Biomédica en Red
2008-2023
Idom (Spain)
2020
Osakidetza
2010-2016
The Di@bet.es Study is the first national study in Spain to examine prevalence of diabetes and impaired glucose regulation. A population-based, cross-sectional, cluster sampling was carried out, with target population being entire Spanish population. Five thousand seventy-two participants 100 clusters (health centres or equivalent each region) were randomly selected a probability proportional size. Participation rate 55.8%. variables clinical demographic structured survey, lifestyle physical...
It is not known whether drugs that block the renin-angiotensin system reduce risk of diabetes and cardiovascular events in patients with impaired glucose tolerance.In this double-blind, randomized clinical trial a 2-by-2 factorial design, we assigned 9306 tolerance established disease or factors to receive valsartan (up 160 mg daily) placebo (and nateglinide placebo) addition lifestyle modification. We then followed for median 5.0 years development (6.5 vital status). studied effects on...
The ability of short-acting insulin secretagogues to reduce the risk diabetes or cardiovascular events in people with impaired glucose tolerance is unknown.In a double-blind, randomized clinical trial, we assigned 9306 participants and either disease factors receive nateglinide (up 60 mg three times daily) placebo, 2-by-2 factorial design valsartan addition participation lifestyle modification program. We followed for median 5.0 years incident (and 6.5 vital status). evaluated effect on...
OBJECTIVE: To undertake a multicentre epidemiological study reflecting acromegaly in Spain. DESIGN: Voluntary reporting of data on patients with to an online database, by the managing physician. METHODS: Data demographics, diagnosis, estimated date initial symptoms and pituitary imaging, visual fields, GH IGF-I concentrations (requested locally), medical, radiotherapy neurosurgical treatments, morbidity mortality were collected. RESULTS: included for 1219 (60.8% women) mean age at diagnosis...
Abstract BACKGROUND Hürthle cell neoplasms, often considered a variant of follicular thyroid represent 3% carcinomas. Only handful publications have focused on the biologic behavior, prognostic factors, and treatment outcomes carcinoma. The objective current study was to identify clinical pathologic features carcinomas that predict disease progression or death. METHODS authors reviewed medical records patients who were treated for carcinoma (HCC) adenoma (HCA) at University Texas M. D....
Several endocrine disorders that share resistance to PTH are grouped under the term pseudohypoparathyroidism (PHP). PHP type I, associated with blunted PTH-induced nephrogenous cAMP formation and phosphate excretion, is subdivided according presence or absence of additional abnormalities, Albright's hereditary osteodystrophy (AHO), reduced Gsalpha activity caused by GNAS mutations.We sought identify molecular defect in four unrelated patients who were thought have PHP-Ia because TSH mild AHO...
Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target Spanish population. In total 5072 people older than 18 years,were randomly selected all over Spain). Socio-demographic and clinical data, survey on habits (physical activity food consumption) weight, height, waist, hip blood pressure were recorder. A fasting draw an oral glucose tolerance test performed. Determinations serum made. follow-up same...
Type 2 diabetes mellitus is associated with a diverse range of pathologies. The aim the study was to determine incidence diabetes-related complications, prevalence coexistent chronic conditions and report multimorbidity in people type living Basque Country. Administrative databases, four cross sections (annually from 2007 2011) were consulted analyse 149,015 individual records patients aged ≥35 years mellitus. data observed were: age, sex, complications (annual rates acute myocardial...
Summary objective To develop a disease‐specific questionnaire suitable to measure health‐related quality of life (HRQOL) in acromegaly (ACROQOL). design, patients and measurements For the development ACROQOL different sources information were used: First, literature search was performed identify relevant papers describing impact HRQOL. Second, 10 endocrinologists identified main domains on HRQOL with acromegaly. Third, in‐depth, semistructured interviews conducted acromegalic items related...
Low physical activity (PA), or sedentary lifestyle, is associated with the development of several chronic diseases. We aimed to investigate current prevalence sedentariness and its association diabetes other cardiovascular risk factors. PA was evaluated in a population-based, cross-sectional, randomly sampled study conducted 2009–2010 Spain. International Physical Activity Questionnaire (SF-IPAQ) used assess PA. 4991 individuals (median age 50 years, 57% women) were studied. Prevalence 32.3%...
The aim of this study was to investigate the national prevalence thyroid dysfunction in Spain and its association with various clinical, environmental, demographic variables.The included 4554 subjects (42.4% men) a mean age 50 years (range 18-93 years), who were participants national, cross-sectional, population-based survey conducted 2009-2010. Data gathered clinical characteristics, physical examination, blood sampling. Thyrotropin, free thyroxine, triiodothyronine, peroxidase antibody...
Lipid metabolism rearrangements in nonalcoholic fatty liver disease (NAFLD) contribute to progression. NAFLD has emerged as a major risk for hepatocellular carcinoma (HCC), where metabolic reprogramming is hallmark. Identification of drivers might reveal therapeutic targets improve HCC treatment. Here, we investigated the contribution transcription factors E2F1 and E2F2 NAFLD-related their involvement rewiring during In mice receiving high-fat diet (HFD) diethylnitrosamine (DEN)...
Background. Brief depression screens have recently been developed, but their use in older or minority populations has not studied. To date, optimal and cutpoints identifed for middle-aged Hispanic primary care patients.
BACKGROUND AND OBJECTIVE The most effective option for the medical treatment of patients with acromegaly is use somatostatin analogues. Long‐acting depot formulations intramuscular injection two analogues have recently become available: octreotide acetate LAR (Sandostatin ® , Novartis Pharma AG) and lanreotide SR (Somatuline Ipsen Biotech). We wished to compare efficacy in acromegalic patients. PATIENTS METHODS A group 125 (67 females; mean age, 47 years; 59 had previous pituitary...
Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder mostly owing to genetic defect in MEN1 gene. Not all patients with phenotype present this Thus, other genes like CDKN and AIP have been showed be involved MEN1-like patients.The aim of study was perform screening our cohort or suspected syndrome by direct sequencing analysis MEN1, CDKN1B AIP, dosage AIP.A total 79 different sporadic familial cases the studied, which 34 them (48%) mutation In two without...
Although most pituitary neoplasms are benign, some grow rapidly, spreading to extrasellar tissues. Definition of these 'giant' adenomas (PAs) is not clear. In order clarify this question, we studied all macroadenomas operated in our hospital during the last 20 years, differentiating those with diameter > or = 3 cm (n 43) and attempting identify their typical features prognosis. The reason for consultation was local 58.3% giant PAs, hormonal 22.9% tumour recurrence 16.7%. Surgery performed...
Recent advances in genetics and epigenetics have revealed an overlap between molecular clinical features of pseudohypoparathyroidism (PHP) subtypes, broadening the previous spectrum PHP genotype-phenotype correlations indicating limitations current classification disease.The aim study was to screen patients with diagnoses type I or pseudo-PHP for underlying defects explore possible findings features.We investigated GNAS locus at level 72 affected (46 women 26 men) from 56 nonrelated...
To analyze the reference range of thyroid-stimulating hormone (TSH) in different BMI categories and its impact on classification hypothyroidism.The study included 3,928 individuals free thyroid disease (without previous disease, no interfering medications, TSH <10 µUI/mL peroxidase antibodies [TPO Abs] <50 IU/mL) who participated a national, cross-sectional, population-based were representative adult population Spain. Data gathered clinical demographic characteristics, physical examination,...
OBJECTIVE To assess the efficacy of insulin pen cap Insulclock on improving glycemic control, treatment adherence, and user satisfaction in people with type 1 diabetes. RESEARCH DESIGN AND METHODS This multicenter, open-label, randomized controlled trial comprised a 4-week run-in phase 6-week double-arm which participants were randomly assigned into an active or masked mode. RESULTS Fifty-five evaluable (active group, n = 26, 29). The increase time range was higher versus group (5.2% vs....
Background: Physicians must have an understanding of patients' medication beliefs in order to enhance adherence. To increase understanding, this study examined how about and four osteoporosis treatments influenced treatment selection Methods: Six focus groups, three with 28 African Americans one 11 non-Hispanic white women, were conducted English. Two groups 16 Hispanics Spanish. The convenience sample was recruited from senior centers housing lower socioeconomic geographic areas. average...