A5057323990- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Obstructive Sleep Apnea Research
- Peroxisome Proliferator-Activated Receptors
- Antioxidant Activity and Oxidative Stress
- Fatty Acid Research and Health
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Gout, Hyperuricemia, Uric Acid
- Neuroscience of respiration and sleep
- Epigenetics and DNA Methylation
- Bariatric Surgery and Outcomes
- Muscle metabolism and nutrition
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Gastrointestinal motility and disorders
Universidad de Málaga
2014-2024
Instituto de Investigación Biomédica de Málaga
2013-2023
Hospital Regional Universitario de Málaga
2002-2021
Instituto de Salud Carlos III
2009-2020
Hospital Clínico Universitario Virgen de la Victoria
2009-2020
Centro de Investigación Biomédica en Red
2011-2020
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2013-2020
Victoria University
2016
Escuela Nacional de Sanidad
2016
University of Eastern Philippines
2016
A recent study using a rat model found significant differences at the time of diabetes onset in bacterial communities responsible for type 1 modulation. We hypothesized that humans could also be linked to specific gut microbiota. Our aim was quantify and evaluate difference composition microbiota between children with healthy determine possible relationship glycemic level.A case-control carried out 16 children. The fecal bacteria investigated by polymerase chain reaction-denaturing gradient...
Several evidences indicate that gut microbiota is involved in the control of host energy metabolism.To evaluate differences composition rat models under different nutritional status and physical activity to identify their associations with serum leptin ghrelin levels.In a case study, forty male rats were randomly assigned one these four experimental groups: ABA group food restriction free access exercise; no exercise feed ad libitum without libitum. The fecal bacteria was investigated by...
This study evaluated the possible prebiotic effect of a moderate intake red wine polyphenols on modulation gut microbiota composition and improvement in risk factors for metabolic syndrome obese patients. Ten patients ten healthy subjects were included randomized, crossover, controlled intervention study. After washout period, consumed de-alcoholized over 30 day period each. The dominant bacterial did not differ significantly between groups after two periods. In patients, increased number...
We assessed whether intermittent hypoxia, which emulates one of the hallmarks obstructive sleep apnoea (OSA), leads to altered faecal microbiome in a murine model. In vivo partial pressure oxygen was measured colonic faeces during hypoxia four anesthetised mice. 10 mice were subjected pattern chronic (20 s at 5% O 2 and 40 room air for 6 h·day −1 ) weeks served as normoxic controls. Faecal samples obtained composition determined by 16S rRNA pyrosequencing bioinformatic analysis Quantitative...
The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, confirmed obese patients. To study relationship between diet and bacterial we analyzed postprandial endotoxemia morbidly patients after fat overload. endotoxin levels were determined serum chylomicron fraction at baseline 3 h overload 40 their related degree of insulin...
The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity type 2 diabetes is not completely understood. Vitamin receptor (VDR) expression in adipose tissue (AT) related to might be regulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].To analyze serum 25(OH)D VDR gene AT according body mass index (BMI) glycemic status the effect of 1,25(OH)2D3 on BMI.Two cohorts were studied: 1) 118 subjects classified their BMI (lean, overweight, obese, or morbidly obese [MO]) (normoglycemic [NG]...
Intermittent hypoxia (IH) mimicking obstructive sleep apnea (OSA) significantly modifies gut microbiota in mice. However, whether these IH-induced microbiome changes are reversible after restoring normal oxygenation (the equivalent of effective OSA therapy) is unknown. The aim this study was to investigate composition and circulating endotoxemia a post-IH normoxic period mouse model OSA. Ten mice were subjected IH (40 sec 21% O2-20 5% O2) for 6 h/day w 10 breathing air (NM) used as controls....
Background Adipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance diabetes. Lipid uptake is the first step to adipose storage. The aim of this study was analyze gene expression factors involved in subcutaneous (SAT) visceral (VAT) according body mass index (BMI) degree (IR). Methods Principal Findings VLDL receptor (VLDLR), lipoprotein lipase (LPL), acylation stimulating protein (ASP), LDL receptor-related 1...
Background FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity a poor atherogenic profile. Objective In patients wide BMI range, we analyze expression hepatic tissues the settings of insulin resistance. Associations between tissue plasma level as well main adipogenic lipolytic genes were also analyzed. Methods The several lipogenic, lipolytic, PPAR family FABP was analyzed by real time PCR. protein total fractions determined western blot....
The expansion of adipose tissue is linked to the development its vasculature, which appears have potential regulate onset obesity. However, at present, there are no studies highlighting relationship between human angiogenesis and obesity-associated insulin resistance (IR).Our aim was analyze compare angiogenic factor expression levels in both subcutaneous (SC) omentum (OM) tissues from morbidly obese patients (n = 26) with low (OB/L-IR) (healthy obese) high (OB/H-IR) degrees IR, lean...
Impaired adipose tissue (AT) lipid handling and inflammation is associated with obesity-related metabolic diseases. Circulating lipopolysaccharides (LPSs) from gut microbiota (metabolic endotoxemia), proposed as a triggering factor for the low-grade in obesity, might also be responsible AT dysfunction. Nevertheless, this hypothesis has not been explored human obesity. To analyze relationship between endotoxemia markers lipogenesis, handling, 33 patients obesity scheduled surgery were...
Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes, cardiovascular disease and cancer. Adipose tissue (AT) plays an important role in metabolic homeostasis, AT dysfunction active diseases. MetS is closely related lifestyle environmental factors. Epigenetics emerged as interesting landscape evaluate possible interconnection between disease, since it can be modulated by factors status. The aim of this study was determine whether impact on global DNA...
Changes in the intestinal microbial community and some metabolic disturbances, including obesity type2 diabetes, are related. Glucagon-like peptide-1 (GLP-1) regulates glucose homeostasis. Microbiota have been linked to incretin secretion. Antibiotic use causes changes diversity composition. Our aim was evaluate relationship between microbiota GLP-1 A prospective case-control study with a Helicobacter pylori-positive patient model involving subjects under eradication therapy (omeprazole,...
Background H. pylori infection and eradication cause perturbations of the gut microbiome. The microbiota has been identified as a potential contributor to metabolic diseases. We evaluate whether these alterations in intestinal composition produced by its posterior with antibiotic treatment could be associated glucose homeostasis metabolically healthy subjects. Methods Forty adult patients infected 20 control subjects were recruited. evaluated before two months after (omeprazole,...
Several different epidemiological studies have examined the association between consumption of tea and coronary heart disease. Some, though not all, support view that or flavonoids reduce risk cardiovascular The aim this study was to determine short-to medium-term effect a green extract on vascular function lipid peroxidation as compared with placebo.The undertaken 14 healthy women, none whom were receiving any medical treatment. Measurements made antibodies immune complexes by ELISA,...
Objective: Polyamines are naturally occurring cationic molecules present in all living cells. Dysregulation of circulating polyamines has been reported several conditions, but little is known about the levels serum chronic metabolic disorders such as type 2 diabetes (T2D). Therefore, aim this study was to evaluate polyamine-related metabolome a cohort syndrome individuals with and without T2D. Design methods: This nested case⁻control within PREDIMED-Plus trial that included 44 patients T2D...
Introduction Adipose tissue is considered an important metabolic tissue, in charge of energy storage as well being able to act systemic homeostasis and inflammation. Epigenetics involves a series factors that are for gene regulation or chromatin structure, mostly DNA methylation histone-tail modifications, which can be modified by environmental conditions (nutrition, lifestyle, smoking…). Since diseases like obesity diabetes closely related lifestyle nutrition, epigenetic deregulation could...