A5025985811- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Sleep and Wakefulness Research
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Neuropeptides and Animal Physiology
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Sleep and related disorders
- Birth, Development, and Health
- Cannabis and Cannabinoid Research
- Advanced Proteomics Techniques and Applications
- Biochemical effects in animals
- Nutrition and Health in Aging
- Diabetes, Cardiovascular Risks, and Lipoproteins
- GDF15 and Related Biomarkers
- Sirtuins and Resveratrol in Medicine
- Health and Lifestyle Studies
- Grit, Self-Efficacy, and Motivation
- Circadian rhythm and melatonin
Instituto de Salud Carlos III
2015-2025
Instituto de Investigación Sanitaria de Santiago
2016-2025
Servicio Gallego de Salud
2016-2025
Complejo Hospitalario Universitario de Santiago
2013-2025
Centro de Investigación Biomédica en Red
2010-2024
Complexo Hospitalario Universitario A Coruña
2015-2023
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2013-2022
Universidade de Santiago de Compostela
2000-2016
European Foundation for the Study of Chronic Liver Failure
2016
Canon (Japan)
2016
Exercise provides clear beneficial effects for the prevention of numerous diseases. However, many molecular events responsible curative and protective role exercise remain elusive. The recent discovery FNDC5/irisin protein that is liberated by muscle tissue in response to might be an important finding with regard this unsolved mechanism. most striking aspect myokine its alleged capacity drive brown-fat development white fat thermogenesis. nature secretion form new controversial. present...
Several evidences indicate that gut microbiota is involved in the control of host energy metabolism.To evaluate differences composition rat models under different nutritional status and physical activity to identify their associations with serum leptin ghrelin levels.In a case study, forty male rats were randomly assigned one these four experimental groups: ABA group food restriction free access exercise; no exercise feed ad libitum without libitum. The fecal bacteria was investigated by...
Ghrelin is a growth hormone-releasing acylated peptide from stomach. The purified consist of 28 amino acids in which the serine 3 residue n-octanoylated. has been reported to increase vitro GH secretion as well vivo plasma levels pentobarbital anaesthetized rats. aim this work was characterize stimulatory effect on freely-moving Furthermore, we compare with GHRH. In addition vehicle, administered different doses (3 nmol/Kg, 12 nmol/Kg and 60 nmol/Kg); GHRH nmol/kg). Plasma were measured...
Ghrelin, the endogenous ligand of GH secretagogue receptor, acts at central level to elicit release and regulate food intake. To elucidate neural circuit that exerts its effects, we measured expression hypothalamic neuropeptides involved in weight regulation secretion after ghrelin administration. Adult male rats, fed or fasted for 72 h, were treated centrally (intracerebroventicularly) with a single dose (5 micro g). After 2, 4, 6 8 agouti-related peptide, melanin-concentrating hormone,...
Hepatocellular carcinoma (HCC) is the sixth most common cancer type and fourth leading cause of cancer-related death. This appears with higher incidence in men during obesity; however, specific mechanisms underlying this correlation are unknown. Adipose tissue, a key organ metabolic syndrome, shows evident gender disparities production adipokines. Levels important adipokine adiponectin decrease puberty, as well obese state. Here, we show that levels responsible for increased liver risk...
Abstract Early-life determinants are thought to be a major factor in the rapid increase of obesity. However, while maternal nutrition has been extensively studied, effects breastfeeding by infant on reprogramming energy balance childhood and throughout adulthood remain largely unknown. Here we show that delayed weaning rat pups protects them against diet-induced obesity adulthood, through enhanced brown adipose tissue thermogenesis expenditure. In-depth metabolic phenotyping this model as...
Recent data indicate that leptin may well play an important regulatory role in the hypothalamo-pituitary-gonadal axis. In order to further unravel mechanisms by which acts, we have studied effect of treatment (8 days) antiserum (5 µl daily; i.c.v.) on LH pulsatility and estrous cycle adult female rats. The administration led a marked decrease as assessed area under curve (13.5 ± 4.7 ng/ml) comparison rats treated with normal rabbit serum (114 53 ng/ml; p < 0.01). Furthermore, showed...
Key points Two‐pore channels (TPCs) were identified as a novel family of endolysosome‐targeted calcium release gated by nicotinic acid adenine dinucleotide phosphate, also intracellular Na + able to control endolysosomal fusion, key process in autophagic flux. Autophagy, an evolutionarily ancient response cellular stress, has been implicated the pathogenesis wide range cardiovascular pathologies, including heart failure. We report direct evidence indicating that TPCs are involved regulating...
Nesfatin-1, a satiety-inducing peptide identified in hypothalamic regions that regulate energy balance, is an integral regulator of homeostasis and putative glucose-dependent insulin coadjuvant. We investigated its production by human cardiomyocytes effects on glucose uptake, the main cardiac transporter GLUT-4 intracellular signaling. Quantitative RT-PCR, Western blots, confocal immunofluorescence microscopy, ELISA murine and/or tissue showed can synthesize secrete nesfatin-1. Confocal...
Two recently discovered hypothalamic peptides, orexin-A and orexin-B, play a role as mediators in the central mechanisms that regulate feeding behavior sleep control. These peptides bind activate two orexins receptors belong to G-protein coupled receptor superfamily. Morphological studies have detected mRNA expression of orexin exclusively rat nervous system. In this paper we demonstrate strong level 1 2 adrenal medulla by RT-PCR immunohistochemistry. The results present study provide first...
Pregnancy and lactation provide excellent models of physiological hyperphagia hyperprolactinemia. To identify possible factors associated with the increased feeding in these situations, we measured hypothalamic mRNA levels three orexigenic neuropeptides--NPY, MCH, orexins--in nonpregnant, pregnant, lactating rats by situ hybridization. NPY content arcuate nucleus was significantly during pregnancy lactation. However, MCH prepro-orexin expression decreased both states. 48 or 72 h fasting...
Abstract Objective: Ghrelin is a 28‐amino‐acid acylated peptide that was recently identified as the endogenous ligand for growth hormone secretagogue receptor. Previous studies have shown ghrelin potently increases release and food intake. The aim of this study to clarify physiological implications in regulation energy balance, by assessing effect undernutrition throughout 21 days normal‐cycling pregnant rats on ghrelin. Research Methods Procedures: We determined levels radioimmunoassay...
The role of obestatin, a 23-amino-acid peptide encoded by the ghrelin gene, on control metabolism pre-adipocyte and adipocytes as well adipogenesis was determined. For in vitro assays, adipocyte 3T3-L1 cells were used to assess obestatin effect cell based regulation key enzymatic nodes, Akt AMPK their downstream targets. vivo white adipose tissue (WAT) obtained from male rats under continuous subcutaneous infusion obestatin. Obestatin activated its targets, GSK3α/β, mTOR S6K1, cells....
Over the years, knowledge regarding relevance of cannabinoid system to regulation metabolism has grown steadily. A central interaction between and ghrelin been suggested regulate food intake. Although stomach is main source CB1 receptor expression in described, little information available possible gastric systems integrated control energy homeostasis. The objective present work was assess functional these two terms intake using a combination vivo vitro approaches. demonstrates that...
Growth hormone (GH) is a major anabolic and the primary regulator of organism growth. Its transcription triggered by GH-releasing (GHRH) through factor cAMP response element-binding protein (CREB) caloric intake. In contrast, deacetylase Sirt1 activated restriction. Therefore, present study investigates how affects CREB function GH synthesis. pharmacological activation with resveratrol (IC50=87 μM) suppressed GHRH-induced secretion from rat anterior pituitary cells in vivo vitro, while...