A5034028785- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Gestational Diabetes Research and Management
- Gut microbiota and health
- Ovarian function and disorders
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Atherosclerosis and Cardiovascular Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Bariatric Surgery and Outcomes
- Diet, Metabolism, and Disease
- Circular RNAs in diseases
- Body Composition Measurement Techniques
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Nutrition, Genetics, and Disease
- Dietary Effects on Health
- Muscle metabolism and nutrition
Instituto de Salud Carlos III
2008-2025
Centro de Investigación Biomédica en Red
2009-2025
Instituto de Investigación Biomédica de Málaga
2018-2025
Universidad de Málaga
2023-2025
Andalusian Centre for Nanomedicine and Biotechnology
2023-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2012-2025
Hospital Clínico Universitario Virgen de la Victoria
2009-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2013-2018
Universidad de Alcalá
2013-2018
Hospital Universitario Ramón y Cajal
2013-2018
A recent study using a rat model found significant differences at the time of diabetes onset in bacterial communities responsible for type 1 modulation. We hypothesized that humans could also be linked to specific gut microbiota. Our aim was quantify and evaluate difference composition microbiota between children with healthy determine possible relationship glycemic level.A case-control carried out 16 children. The fecal bacteria investigated by polymerase chain reaction-denaturing gradient...
Several evidences indicate that gut microbiota is involved in the control of host energy metabolism.To evaluate differences composition rat models under different nutritional status and physical activity to identify their associations with serum leptin ghrelin levels.In a case study, forty male rats were randomly assigned one these four experimental groups: ABA group food restriction free access exercise; no exercise feed ad libitum without libitum. The fecal bacteria was investigated by...
Abstract Context Gut microbiota play a major role in health and disease by influencing physiology, metabolism, nutrition, immune function. Objective To evaluate the composition of gut women with polycystic ovary syndrome (PCOS), focusing on influence sex, sex hormones obesity associations found. Design Cross-sectional study. Setting Academic hospital. Participants We recruited 15 PCOS, 16 nonhyperandrogenic control women, men. were classified as nonobese (<30 kg/m2) or obese (≥30...
MicroRNAs (miRNAs) are small, noncoding RNA sequences that negatively regulate gene expression at the post-transcriptional level. miRNA-21, miRNA-27b, miRNA-103, and miRNA-155 have been associated with metabolic disorders such as obesity diabetes, which also polycystic ovary syndrome (PCOS).We aimed to evaluate effects of sex, sex hormones, PCOS their interactions on in circulation these miRNAs.This was a case-control study.The setting an academic hospital.We included 12 control women,...
The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, confirmed obese patients. To study relationship between diet and bacterial we analyzed postprandial endotoxemia morbidly patients after fat overload. endotoxin levels were determined serum chylomicron fraction at baseline 3 h overload 40 their related degree of insulin...
To determine the usefulness of measuring hemoglobin A(1c) (A1C), alone or combined with fasting glucose test, compared oral tolerance test (OGTT) for reassessment carbohydrate metabolism status in postpartum women a history gestational diabetes mellitus (GDM).We evaluated by performing OGTT and A1C tests 231 prior GDM 1 year after delivery.The prevalence abnormal was 45.89% criterion, 19.05% 38.10% 46.75% A1C-fasting criteria. Using as gold standard, according to criterion had 22.64%...
The postprandial state seems to have a direct influence on oxidative status and insulin resistance. We determined the effect of an increase in plasma triglycerides after high-fat meal stress severely obese patients with differing degrees study was undertaken 60 persons who received 60-g fat overload commercial preparation. Measurements were made resistance, activity various antioxidant enzymes, total capacity (TAC) concentration thiobarbituric acid reactive substances (TBARS). greater...
The analysis of microbial phenolic metabolites in fecal samples from vivo studies is crucial to understanding the potential modulatory effects derived polyphenol consumption and its overall health effects, particularly at gut level. In this study, composition human feces collected after regular either red wine, dealcoholized or gin was analyzed by UPLC-ESI-MS/MS. Red wine interventions produce a change content eight acids, which are probably catabolism flavan-3-ols anthocyanins, main...
OBJECTIVE Cell death determines the onset of obesity and associated insulin resistance. Here, we analyze relationship among obesity, adipose tissue apoptosis, signaling. RESEARCH DESIGN AND METHODS The expression levels initiator (CASP8/9) effector (CASP3/7) caspases as well antiapoptotic B-cell lymphoma (BCL)2 inflammatory markers were assessed in visceral (VAT) subcutaneous (SAT) from patients with different degrees without resistance or diabetes. Adipose explants lean subjects cultured...
Objective This study aimed to analyze the potential association of different microRNA (miRNA) molecules with both type 2 diabetes (T2D) and obesity determine their target genes. Methods Quantitative PCR was used miR‐20b, miR‐296, Let‐7f levels in human visceral subcutaneous adipose tissues (ATs) relation T2D, miRTarBase 4.0 for validation genes, Protein Analysis Through Evolutionary Relationships (PANTHER) Classification System Database Annotation, Visualization Integrated Discovery (DAVID)...