A5026662417- Ovarian function and disorders
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Hormonal Regulation and Hypertension
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Lipid metabolism and disorders
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Diabetes Management and Research
- Sexual Differentiation and Disorders
- Thyroid Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Ovarian cancer diagnosis and treatment
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Pharmacology and Obesity Treatment
- Cardiovascular Health and Disease Prevention
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Gestational Diabetes Research and Management
- Bariatric Surgery and Outcomes
Hospital Universitario Ramón y Cajal
2016-2025
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2016-2025
Instituto Ramón y Cajal de Investigación Sanitaria
2016-2025
Universidad de Alcalá
2016-2025
Instituto de Salud Carlos III
2008-2024
Ghent University Hospital
2023
Instituto Cajal
2017-2022
Weatherford College
2021
Center for Human Reproduction
2013-2021
Diabetes Australia
2021
The Androgen Excess Society (AES) charged a task force to review all available data and recommend an evidence-based definition for polycystic ovary syndrome (PCOS), whether already in use or not, guide clinical diagnosis future research.Participants included expert investigators the field.Based on systematic of published peer-reviewed medical literature, by querying MEDLINE databases, we tried identify studies evaluating epidemiology phenotypic aspects PCOS.The drafted initial report,...
We prospectively estimated the prevalence of polycystic ovary syndrome (PCOS), as defined by NIH/NICHHD 1990 endocrine criteria, in a population 154 Caucasian women reproductive age reporting spontaneously for blood donation. Anthropometric data; presence hirsutism, acne, and androgenic alopecia; menstrual history were recorded single investigator. In 145 women, samples also obtained measurement serum androgen levels. PCOS was 1) oligomenorrhea, 2) clinical and/or biochemical...
BACKGROUNDThe diagnosis of polycystic ovary syndrome (PCOS) relies on clinical, biological and morphological criteria. With the advent ultrasonography, follicle excess has become main aspect ovarian morphology (PCOM). Since 2003, most investigators have used a threshold 12 follicles (measuring 2–9 mm in diameter) per whole ovary, but that now seems obsolete. An increase volume (OV) and/or area may also be considered accurate markers PCOM, yet their utility compared with remains unclear.
Context: The polycystic ovary syndrome (PCOS) is frequently associated with obesity. However, there are very few data about PCOS in morbid obesity, especially regard to its evolution after bariatric surgery.
<h3>Background</h3> Surprisingly, the prevalence of polycystic ovary syndrome (PCOS) in otherwise unselected overweight or obese women is unknown, despite obesity being frequent patients with PCOS. We conducted present study to obtain an unbiased estimate PCOS and premenopausal from Spain. <h3>Methods</h3> All reporting Department Endocrinology, Hospital Universitario Ramón y Cajal, for dietary treatment May 2002 December 2005 were prospectively recruited. Women referred any other reason...
Abstract Context Gut microbiota play a major role in health and disease by influencing physiology, metabolism, nutrition, immune function. Objective To evaluate the composition of gut women with polycystic ovary syndrome (PCOS), focusing on influence sex, sex hormones obesity associations found. Design Cross-sectional study. Setting Academic hospital. Participants We recruited 15 PCOS, 16 nonhyperandrogenic control women, men. were classified as nonobese (&lt;30 kg/m2) or obese (≥30...
We have studied whether, or not, tissue-specific regulatory mechanisms provide normal 3,5,3'-triiodothyronine (T3) concentrations simultaneously in all tissues of a hypothyroid animal receiving thyroxine (T4), an assumption implicit the replacement therapy patients with T4 alone. Thyroidectomized rats were infused placebo 1 10 doses (0.2-8.0 micrograms per 100 grams body weight day). Placebo-infused intact served as controls. Plasma and obtained after 12-13 d infusion. thyrotropin plasma...
We have recently shown that it is not possible to restore euthyroidism completely in all tissues of thyroidectomized rats infused with T4 alone. The present study was undertaken determine whether this achieved when T3 added the continuous sc infusion T4. Thyroidectomized were placebo or (0.80 and 0.90 microgram/100 g BW.day), alone combination (0.10, 0.15, 0.20 BW.day). Placebo-infused intact served as euthyroid controls. Plasma 12 obtained after days infusion. TSH plasma tissue determined...
We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in pathogenesis polycystic ovary syndrome (PCOS).Seventy-six PCOS patients 40 non-hyperandrogenic women matched for BMI degree obesity were included. Serum levels, anthropometrical hormonal variables, 45 T-->G 276 G-->T polymorphisms gene, -420 C-->G variant analysed.Serum concentrations reduced compared with controls (P = 0.038) irrespective obesity, whereas serum levels...
Low-grade chronic inflammation is involved in the pathogenesis of metabolic syndrome and atherosclerosis, serum levels inflammatory cytokines are useful cardiovascular risk markers. We have studied IL-18 concentrations women with polycystic ovary (PCOS), focusing on its relationship obesity indexes insulin resistance. Sixty consecutive PCOS 34 healthy were recruited. Serum lipid hormone profiles measured. The sensitivity index was calculated from glucose during an oral tolerance test. Data...
Background: Substituting part of the dose l-thyroxine with small but supraphysiologic doses liothyronine in hypothyroid patients has yielded conflicting results. Objective: To evaluate combinations plus that match proportions present normal secretions human thyroid gland. Design: Randomized, double-blind, crossover trial. Setting: Academic research hospital. Participants: 28 women overt primary hypothyroidism. Intervention: Crossover trial comparing treatment l-thyroxine, 100 µg/d (standard...
Abstract Context: The diagnosis of the polycystic ovary syndrome requires exclusion nonclassical congenital adrenal hyperplasia (NCAH). Objective: Our objective was to evaluate actual prevalences 21-hydroxylase and 11β-hydroxylase deficiencies among women presenting with hyperandrogenic complaints. Settings: This study performed at an academic hospital. Patients: A total 270 consecutive unselected symptoms were prospectively recruited. Interventions: Basal ACTH-stimulated 11-deoxycortisol...
The polycystic ovary syndrome (PCOS) is frequently associated with visceral obesity, suggesting that omental adipose tissue might play an important role in the pathogenesis of syndrome.The objective was to study expression profiles fat biopsy samples obtained from morbidly obese women or without PCOS at time bariatric surgery.This a case-control study.We conducted academic hospital.Eight patients and seven nonhyperandrogenic submitted surgery because morbid obesity.Biopsy were during...