M. Rosa Bernal‐López
A5036360770- Nutritional Studies and Diet
- Diet and metabolism studies
- Diabetes Treatment and Management
- Obesity, Physical Activity, Diet
- Diabetes Management and Research
- Cardiovascular Function and Risk Factors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Consumer Attitudes and Food Labeling
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Diet, Metabolism, and Disease
- Heart Failure Treatment and Management
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Cardiac Health and Mental Health
- Chronic Disease Management Strategies
- Body Composition Measurement Techniques
- Atherosclerosis and Cardiovascular Diseases
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
Instituto de Salud Carlos III
2016-2025
Instituto de Investigación Biomédica de Málaga
2016-2025
Hospital Regional Universitario de Málaga
2015-2025
Centro de Investigación Biomédica en Red
2015-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2013-2025
Universidad de Málaga
2016-2025
Andalusian Centre for Nanomedicine and Biotechnology
2022-2025
Centro de Salud Casa del Barco
2024
Universidad de Navarra
2024
Universitat Ramon Llull
2024
High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on changes.To assess effect a physical activity education program quality.Preliminary exploratory interim analysis an ongoing trial. In 23 research centers in Spain, 6874 men women aged 55 to 75 years with metabolic syndrome no cardiovascular disease were enrolled trial between September 2013 December 2016, final...
The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity type 2 diabetes is not completely understood. Vitamin receptor (VDR) expression in adipose tissue (AT) related to might be regulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].To analyze serum 25(OH)D VDR gene AT according body mass index (BMI) glycemic status the effect of 1,25(OH)2D3 on BMI.Two cohorts were studied: 1) 118 subjects classified their BMI (lean, overweight, obese, or morbidly obese [MO]) (normoglycemic [NG]...
The Mediterranean diet is a well-recognized healthy that has shown to induce positive changes in gut microbiota. Lifestyle such as along with physical activity could aid weight loss and improve cardiovascular risk factors.To investigate the effect of an intensive lifestyle intervention on microbiota.This substudy PREDIMED-Plus (Prevención con Dieta Mediterránea-Plus), randomized controlled trial conducted overweight/obese men women (aged 55-75 y) metabolic syndrome. group (IG) underwent...
The association between ultra-processed food (UPF) and risk of cardiometabolic disorders is an ongoing concern. Different processing-based classification systems have originated discrepancies in the conclusions among studies. To test whether UPF consumption markers changes with system, we used baseline data from 5636 participants (48.5% female 51.5% male, mean age 65.1 ± 4.9) PREDIMED-Plus (“PREvention MEDiterranean DIet”) trial. Subjects presented overweight or obesity met at least three...
Dietary patterns can produce an environmental impact. Changes in people's diet, such as the increased consumption of ultra-processed food (UPF) not only influence human health but also environment sustainability.Assessment impact 2-year changes UPF on greenhouse gas emissions and water, energy land use.A longitudinal study after a dietary intervention including 5879 participants from Southern European population between ages 55-75 years with metabolic syndrome.Food intake was assessed using...
This article aims to estimate the differences in environmental impact (greenhouse gas [GHG] emissions, land use, energy used, acidification and potential eutrophication) after one year of promoting a Mediterranean diet (MD). Baseline 1-year follow-up data from 5800 participants PREDIMED-Plus study were used. Each participant's food intake was estimated using validated semi-quantitative frequency questionnaires, adherence MD Dietary Score. The influence on assessed through EAT-Lancet...
Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn cardiovascular disease (CVD) remains unclear individuals at high CVD risk. Objective: To assess association between MetS components an adult Mediterranean population Design: Baseline assessment nutritional adequacy participants (n = 6560, men women, 55–75 years old, with overweight/obesity MetS) PREvención con DIeta MEDiterránea (PREDIMED)-Plus randomized trial. Methods: Assessment (total fat,...
Objective: This study was designed to evaluate the impact of a teleassistance system on metabolic control type 2 diabetes patients. Research Design and Methods: We conducted 1-year controlled parallel-group trial comparing patients randomized (1) an intervention group, assigned using real-time transmission blood glucose results, with immediate reply when necessary, telephone consultations, or (2) being regularly followed-up at their healthcare center. Study subjects were >30 years age...
Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, which is present adipocytes stromal vascular fraction of human adipose tissue (AT), up-regulated AT insulin-resistant morbidly compared with healthy lean subjects. The aim this study was to explore effects vitro vivo administration its on adipocyte functions from T2D
Background and aims Obesity is linked to elevated levels of inflammatory serum markers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFa). Adiponectin resistin are adipokines related obesity. It has been described that adipose tissue presents a high production secretion these diverse pro-inflammatory molecules, which may have local effects on the physiology fat cells well systemic other organs. Our aim was evaluate impact lifestyle modifications, by...
Objective: Polyamines are naturally occurring cationic molecules present in all living cells. Dysregulation of circulating polyamines has been reported several conditions, but little is known about the levels serum chronic metabolic disorders such as type 2 diabetes (T2D). Therefore, aim this study was to evaluate polyamine-related metabolome a cohort syndrome individuals with and without T2D. Design methods: This nested case⁻control within PREDIMED-Plus trial that included 44 patients T2D...
Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of alterations that can result in severe and even death. Consumption ultra-processed foods (UPF) has been associated with obesity related comorbidities. However, the link between UPF NAFLD not sufficiently assessed. We aimed to investigate prospective association consumption health biomarkers. Methods: followed for 1 year 5867 older participants overweight/obesity metabolic syndrome (MetS) from PREDIMED-Plus trial. A validated...
Obesity is associated with a low-grade chronic inflammation state. As consequence, adipose tissue expresses pro-inflammatory cytokines that propagate inflammatory responses systemically elsewhere, promoting whole-body insulin resistance and consequential islet β-cell exhaustation. Thus, considered the early stage of type 2 diabetes. However, there evidence obese individuals never develop diabetes indicating mechanisms governing association between increase factors are much more complex...