Olga Castañer
A5082521874- Nutritional Studies and Diet
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Consumer Attitudes and Food Labeling
- Cholesterol and Lipid Metabolism
- Fatty Acid Research and Health
- Antioxidant Activity and Oxidative Stress
- Edible Oils Quality and Analysis
- Dietary Effects on Health
- Diet, Metabolism, and Disease
- Health and Lifestyle Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health in Aging
- Metabolomics and Mass Spectrometry Studies
- Bariatric Surgery and Outcomes
- Gut microbiota and health
- Physical Activity and Health
- Obesity and Health Practices
- Sodium Intake and Health
- Cardiovascular Function and Risk Factors
- Nuts composition and effects
- Blood Pressure and Hypertension Studies
- Eating Disorders and Behaviors
- Cancer, Lipids, and Metabolism
- Cardiovascular Disease and Adiposity
Centro de Investigación Biomédica en Red
2016-2025
Instituto de Salud Carlos III
2016-2025
Hospital Del Mar
2016-2025
Hospital del Mar Research Institute
2016-2025
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2023-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2016-2025
Comunidad de Madrid
2025
Municipal Institute for Medical Research
2015-2024
University of the Basque Country
2024
Instituto de Investigación Biosanitaria de Granada
2024
OBJECTIVE The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body and risk factors PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the effectiveness an intensive lifestyle intervention primary prevention. RESEARCH DESIGN AND METHODS Overweight/obese adults with metabolic syndrome aged 55–75 years (n = 626) were randomized based energy-restricted Mediterranean diet, physical activity...
Little evidence exists on the effect of an energy-unrestricted healthy diet metabolic syndrome. We evaluated long-term Mediterranean diets ad libitum incidence or reversion
CHD, coronary heart disease;d, day; erMedDiet, energy-reduced Mediterranean diet (based on the 17-item questionnaire); MedDiet, 14-item 44,45 E, energy intake; LDL, low
Background: The biological functions of high-density lipoproteins (HDLs) contribute to explaining the cardioprotective role lipoprotein beyond quantitative HDL cholesterol levels. A few small-scale interventions with a single antioxidant have improved some functions. However, date, no long-term, large-scale, randomized controlled trial has been conducted assess effects an antioxidant-rich dietary pattern (such as traditional Mediterranean diet [TMD]) on function in humans. Methods: This...
Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian locomotor output cycles protein kaput), one of those genes, known to glucose metabolism in rodent models. Cross-sectional studies humans have reported associations between this locus obesity, plasma glucose,...
High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on changes.To assess effect a physical activity education program quality.Preliminary exploratory interim analysis an ongoing trial. In 23 research centers in Spain, 6874 men women aged 55 to 75 years with metabolic syndrome no cardiovascular disease were enrolled trial between September 2013 December 2016, final...
Diabetic retinopathy (DR) is a devastating complication of individuals with type 2 diabetes mellitus. The retina rich in long-chain ω-3 polyunsaturated fatty acids (LCω3PUFAs), which are substrate for oxylipins anti-inflammatory and antiangiogenic properties. Experimental models support dietary LCω3PUFA protection against DR, but clinical data lacking.To determine whether intake relates to decreased incidence sight-threatening DR older than 55 years.In late 2015, we conceived prospective...
Objective. To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on plasma concentrations inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease. Design Setting. 66 participants from primary care centers affiliated with Hospital Clinic Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts low-fat (LFD). At baseline 5 years, we evaluated changes 24 biomarkers related to...
Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims the present study are to describe dietary in a population syndrome (MetS) and examine association between components MetS. This cross-sectional analysis involved 6633 men women included PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. content foods was estimated from Phenol-Explorer 3.6 database. mean total 846 ± 318 mg/day. Except for stilbenes, had higher than men. Total older participants...
The Mediterranean diet is a well-recognized healthy that has shown to induce positive changes in gut microbiota. Lifestyle such as along with physical activity could aid weight loss and improve cardiovascular risk factors.To investigate the effect of an intensive lifestyle intervention on microbiota.This substudy PREDIMED-Plus (Prevención con Dieta Mediterránea-Plus), randomized controlled trial conducted overweight/obese men women (aged 55-75 y) metabolic syndrome. group (IG) underwent...
The association between ultra-processed food (UPF) and risk of cardiometabolic disorders is an ongoing concern. Different processing-based classification systems have originated discrepancies in the conclusions among studies. To test whether UPF consumption markers changes with system, we used baseline data from 5636 participants (48.5% female 51.5% male, mean age 65.1 ± 4.9) PREDIMED-Plus (“PREvention MEDiterranean DIet”) trial. Subjects presented overweight or obesity met at least three...
The production and consumption of ultra-processed foods (UPF) has increased considerably during the last years worldwide. Collective evidence shows association between UPF adverse health outcomes, including inflammatory gastro-intestinal disorders obesity. gut microbiota been suggested as potential mediator effects on metabolism health. However, few studies have conducted in order to elucidate these aspects. Therefore, aim present study was assess cross-sectional associations a population...
An altered gut microbiota has been associated with insulin resistance, a metabolic dysfunction consisting of cellular signaling impairment. The aim the present study is to determine taxonomic and functional fecal signatures HOMA-IR index in population high cardiovascular risk.A total 279 non-diabetic individuals (55-75 years aged) overweight/obesity syndrome were stratified according tertiles index. Blood biochemical parameters, anthropometric measurements samples collected at baseline....
Abstract Background Research related to sustainable diets is highly relevant provide better understanding of the impact dietary intake on health and environment. Aim To assess association between adherence an energy-restricted Mediterranean diet amount CO 2 emitted in older adult population. Design population Using a cross-sectional design, energy-reduced Diet (erMedDiet) score emissions 6646 participants was assessed. Methods Food erMedDiet assessed using validated food frequency...