A5084146884- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Cardiovascular Health and Disease Prevention
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Blood Pressure and Hypertension Studies
- Transplantation: Methods and Outcomes
- Diabetes Management and Education
- Organ Donation and Transplantation
- Antioxidant Activity and Oxidative Stress
- Breastfeeding Practices and Influences
- Health and Lifestyle Studies
- Lipoproteins and Cardiovascular Health
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2014-2025
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2013-2025
Instituto de Salud Carlos III
2015-2025
Hospital Clínic de Barcelona
2014-2025
Fundació Clínic per a la Recerca Biomèdica
2025
Universitat de Barcelona
2015-2023
Centro de Investigación Biomédica en Red
2017-2023
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2015-2020
Idom (Spain)
2020
Pasqual Maragall Foundation
2020
To date no clinical trials have evaluated the role of dietary patterns on incidence microvascular diabetes complications. We hypothesized that a nutritional intervention based Mediterranean diet (MedDiet) would greater protective effect diabetic retinopathy and nephropathy than low-fat control diet.This was post hoc analysis cohort patients with type 2 participating in PREvención con DIeta MEDiterránea (PREDIMED) study, multicenter randomized trial conducted population at high cardiovascular...
Preeclampsia (PE) and type 1 diabetes (T1D) are significant risk factors for cardiovascular disease (CVD), but their combined effect on atherosclerosis progression has not been fully explored. This study aimed to evaluate the impact of T1D PE atherosclerosis. Prospective cohort 112 women divided into four groups: + /PE (n = 28), /PE- T1D-/PE T1D-/PE- 28). Participants underwent an initial assessment a follow-up visit five years later, which included anthropometric evaluation, blood tests,...
Pancreas graft status in simultaneous pancreas-kidney transplant (SPKTx) is currently assessed by nonspecific biochemical markers, typically amylase or lipase. Identifying a noninvasive biomarker with good sensitivity detecting early pancreas rejection could improve SPKTx management.Here, we developed pilot study to explore donor-derived cell-free DNA (dd-cfDNA) performance predicting biopsy-proven acute (P-BPAR) of the cohort 36 recipients biopsy-matched plasma samples. dd-cfDNA was...
Objective— Bilirubin is a potent antioxidant that has been inversely related to cardiovascular disease. There little information on serum total bilirubin (TB) in relation atherosclerosis familial dyslipidemia. We assessed the association between TB and carotid femoral this high-risk group. Approach Results— evaluated 464 individuals with dyslipidemia (56% men; median age, 48 years), 322 hypercholesterolemia, 142 combined hyperlipidemia. Carotid arteries were imaged bilaterally standardized...
Although insulin resistance (IR) is a growing trait among type 1 diabetes (T1D) population, its relationship with atherosclerosis has been scarcely studied. We assessed the association between IR indexes and carotid in T1D, population at high cardiovascular disease (CVD) risk.We evaluated 191 participants T1D no prior CVD least one of following criteria: ≥40 years old; diabetic nephropathy; or duration ≥10 harbouring ≥1 additional risk factor. was metabolic syndrome (MetS) harmonized...
OBJECTIVE To evaluate the concordance between 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with EASD (ESC/EASD-2019) Steno T1 Risk Engine (Steno-Risk) risk scales for individuals type 1 diabetes (T1D) without disease (CVD) to analyze relationships of their use identification preclinical atherosclerosis. RESEARCH DESIGN AND METHODS We consecutively selected patients T1D, CVD, age ≥40 years, nephropathy, and/or ≥10 years T1D evolution...
This study aimed to evaluate the influence of maternal diabetes in risk neurodevelopmental disorders offspring prenatal and postnatal periods.This cohort included singleton gestational mellitus (GDM) pregnancies >22 weeks' gestation with live newborns between 1991 2008. The control group was randomly selected matched (1:2) for age, weeks birth year. Cox regression models estimated effect GDM on attention-deficit/hyperactivity disorder (ADHD), autism spectrum (ASD), type 2 (T2DM). Moreover,...
People with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD). The Mediterranean diet is associated reduced CVD; however, the evidence in T1D scarce. We aimed to analyse relationships between adherence energy-restricted (erMEDd) and carotid atherosclerosis.
People living with type 1 diabetes (T1D) have an increased risk of cardiovascular disease (CVD), and it is the leading cause morbidity mortality in this population. CVD increases each uncontrolled factor, even individuals good glycaemic control. Recommendations for assessing T1D population are extended from those 2 (T2D) though physiopathology underlying mechanisms atherosclerosis poorly understood differ T2D. Unlike assessment microvascular complications, which well established T1D, far...
The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy Framingham-REGICOR scale, validated for Spanish population, to identify future CVD participants, who were predefined as being at high-risk PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and impact adherence Mediterranean diet on across risk categories.In a post hoc analysis, we value baseline estimated 5966...
Improvement in insulin alternatives is leading to a delayed presentation of microvascular and macrovascular complications diabetes. The objective this study was evaluate the long-term outcomes older (≥50 years) diabetic patients who receive pancreas transplantation (PT).We retrospectively evaluated all 338 PTs performed at our center between 2000 2016 (mean follow-up 9.4±4.9 years). Recipient graft survivals were estimated for up 10 years after PT. Major adverse cardiovascular events (MACEs)...
Lipoprotein disturbances have been associated with increased cardiovascular disease (CVD) risk in type 1 diabetes mellitus (T1DM). We assessed the advanced lipoprotein profile T1DM individuals, and analysed differences non-diabetic counterparts.This cross-sectional study involved 508 adults 347 controls, recruited from institutions a Mediterranean region of Spain. Conventional (assessed by nuclear magnetic resonance [NMR] spectroscopy) profiles were analysed. Crude adjusted (by age, sex,...
People with type 1 diabetes (T1D) have a high cardiovascular disease (CVD) risk, which remains the leading cause of death in this population. Despite improved control several classic risk factors, particularly better glycaemic control, morbidity and mortality continue to be significantly higher than general In routine clinical practice, estimating (CVR) people T1D using scales or equations is often imprecise because much evidence comes from pooled samples 2 (T2D) extrapolations studies...
Abstract Aims To explore the relationship between severe hypoglycemia (SH) and awareness with preclinical atherosclerosis in type 1 diabetes (T1D). Materials Methods Cross‐sectional study patients T1D without cardiovascular disease (CVD), ≥1 of following: ≥40 years, diabetic kidney disease, or ≥10 years duration another risk factor. CVD was estimated Steno T1 Risk Engine (Steno‐Risk). Carotid plaque evaluated using standardised ultrasonography protocol. Logistic regression models adjusted...
Since the arrival of continuous glucose monitoring (CGM), relationship between management indicator (GMI) and HbA1c has been a topic considerable interest in diabetes research. This study aims to explore association GMI/HbA1c ratio presence preclinical carotid atherosclerosis type 1 (T1D). Individuals with T1D no prior history cardiovascular disease were recruited from two centers. Carotid ultrasonography was performed using standardized protocol plaques defined as intima-media thickness ≥...