A5048172759- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Inflammasome and immune disorders
- Chemokine receptors and signaling
- Signaling Pathways in Disease
- Viral Infections and Immunology Research
- Immune Response and Inflammation
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Complement system in diseases
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- Lipoproteins and Cardiovascular Health
- Cardiovascular Disease and Adiposity
- NF-κB Signaling Pathways
- IL-33, ST2, and ILC Pathways
- Acute Myocardial Infarction Research
- Cardiac Ischemia and Reperfusion
- Neuroinflammation and Neurodegeneration Mechanisms
- Biomarkers in Disease Mechanisms
- Systemic Lupus Erythematosus Research
- Protease and Inhibitor Mechanisms
Oslo University Hospital
2015-2025
University of Oslo
2014-2025
Pfizer (United States)
2024
657 Oslo
2021
Institute of Physiology and Basic Medicine
2006-2017
Faculty (United Kingdom)
2017
Instituto de la Grasa
2017
Universidad de Sevilla
2017
Universidad Pablo de Olavide
2017
University of Debrecen
2017
Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) is considered necessary for initiating profound sterile inflammatory response. NLRP3 forms multi-protein complexes Apoptosis-associated Speck-like protein containing Caspase recruitment (ASC) and Caspase-1, which activate pro-interleukin-1β (IL-1β) pro-IL-18. The role of in cardiac cells not known. Thus, we investigated the expression function during myocardial ischaemia.Myocardial infarction (MI) was...
Although the participation of inflammation in atherogenesis is widely recognized, identification different components has not been clarified. In particular, role plaque destabilization fully understood.Our main findings were as follows: (1) a microarray experiment, we identified visfatin, one most recently adipokines, gene that was markedly enhanced carotid plaques from symptomatic compared with asymptomatic individuals. This finding confirmed when 7 patients and 14 lesions examined...
Recent metabolomic, experimental and clinical studies have demonstrated that trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite from dietary phosphatidylcholine carnitine, is strong predictor of coronary artery disease (CAD). This finding suggests link between the gut microbiota atherosclerosis. The potential impact TMAO in chronic heart failure (HF) unknown. We hypothesized levels would provide prognostic information about adverse outcomes HF.Prospective, observational study...
Neutrophil gelatinase-associated lipocalin (NGAL or lipocalin-2) is a glycoprotein with bacteriostatic properties. Growing evidence suggests that NGAL may also be involved in cell survival, inflammation, and matrix degradation. We therefore aimed to investigate the role of heart failure (HF). Our main findings were (i) patients acute post-myocardial infarction (MI) HF (n = 236) chronic 150) had elevated serum levels (determined by enzyme immunoassay), significantly correlated clinical...
Background The NLR family, pyrin domain containing 3 ( NLRP 3) inflammasome is an interleukin IL )‐1β and ‐18 cytokine processing complex that activated in inflammatory conditions. role of the pathogenesis atherosclerosis myocardial infarction not fully understood. Methods Results Atherosclerotic plaques were analyzed for transcripts inflammasome, ‐1β release. Swedish First‐ever Infarction study Ac‐county FIA ) cohort consisting DNA from 555 patients 1016 healthy individuals was used to...
Persistent inflammation appears to play a role in the development of heart failure (HF). Osteoprotegerin (OPG), receptor activator nuclear factor-kappaB (RANK), and RANK ligand (RANKL) are newly discovered members tumor necrosis factor superfamily that critical regulators bone metabolism but appear also be involved immune responses. We hypothesized OPG/RANK/RANKL axis could pathogenesis (HF), this hypothesis was investigated both experimental clinical studies.Our main novel findings were as...
Based on its role in inflammation and matrix degradation, we hypothesized a for osteoprotegerin (OPG), RANK, RANK ligand (RANKL) coronary artery disease.We examined the expression of various members OPG/RANKL/RANK axis patients with stable unstable angina atherosclerotic lesions apolipoprotein E-deficient (apoE(-/-)) mice. Our findings were: (1) Serum levels OPG were raised (n=40), but not those comparing controls (n=20); (2) mRNA RANKL increased T-cells accompanied by monocytes; (3) strong...
Fetuin A has been associated with insulin resistance and the metabolic syndrome. We therefore explored role of fetuin in nonalcoholic fatty liver disease (NAFLD).Cross-sectional intervention studies.We included 111 subjects histologically proven NAFLD whom 44 participated a randomized, controlled trial metformin. One hundred thirty-one healthy 13 undergoing hepatic surgery for metastatic cancer served as controls. Main outcome variables were circulating levels according to presence NAFLD,...
Abstract Aims Recent reports have suggested that patients with heart failure (HF) an altered gut microbiota composition; however, associations diet remain largely uninvestigated. We aimed to explore differences in the between HF reduced ejection fraction and healthy controls, focusing on disease severity. Methods results The composition of two cross‐sectional cohorts (discovery, n = 40 validation, 44) systolic controls ( 266) was characterized by sequencing bacterial 16S rRNA gene. overall...
Although modulation of inflammatory processes has been suggested as a new treatment modality in heart failure (HF), our knowledge about abnormalities the cytokine network during HF is still limited. On basis previous cDNA array study examining peripheral blood mononuclear cells from patients, we hypothesized role for activin A, member transforming growth factor (TGF)-beta superfamily, pathogenesis HF.This had 4 main and novel findings. First, serum levels A were significantly elevated...
Inflammation is important in atherogenesis. Interleukin (IL)-1 the prototypic inflammatory cytokine. We hypothesized a dysbalance between and anti-inflammatory mediators IL-1 family coronary artery disease (CAD) possible modulation of these by HMG-CoA inhibitors (statins).In microarray screening experiment examining peripheral blood mononuclear cells (PBMCs) from 6 CAD patients 4 healthy control subjects, IL-1beta was identified as 1 25 genes whose expression were upregulated downregulated...
Objective: Increasing evidence supports a role for inflammation in chronic heart failure (CHF). However, the source and mechanism this immune activation are unknown. To address issue we investigated gene expression of cytokines surface activity markers T-cells monocytes from CHF patients healthy controls. Methods: Gene was analysed by real-time RT-PCR flow cytometry 14 nine Surface were cytometry. Results: showed enhanced chemokines, ligands tumor necrosis factor superfamily, as well...
Chemokines play a pathogenic role in atherogenesis and plaque destabilization by activating directing leukocytes into the atherosclerotic plaque. However, stromal cell-derived factor (SDF)-1 was recently found to have antiinflammatory effects, we hypothesized that this chemokine could beneficial coronary artery disease.Plasma levels of SDF-1alpha were significantly decreased patients with stable (n=30) unstable angina compared healthy control subjects (n=20), particularly those disease. By...
Based on their role in T-cell homing into nonlymphoid tissue, we examined the of homeostatic chemokines CCL19 and CCL21 common receptor CCR7 coronary artery disease (CAD).We performed studies patients with stable (n=40) unstable angina healthy controls (n=20), vitro T-cells macrophages, apolipoprotein-E-deficient (ApoE-/-) mice human atherosclerotic carotid plaques. We found increased levels within lesions ApoE-/- mice, plaques, plasma CAD patients. Whereas strong expression was seen from...
Nonalcoholic fatty liver disease (NAFLD) is the most common in Western and non-Western countries, but its pathogenesis not fully understood.Based on role of nicotinamide phosphoribosyltransferase (NAMPT) fat glucose metabolism cell survival, we hypothesized a for NAMPT/visfatin NAFLD-related disease.We conducted clinical studies at referral medical center well-characterized NAFLD patients (n = 58) healthy controls 27). In addition performed experimental vitro hepatocytes.We examined 1)...