A5059876442- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Monoclonal and Polyclonal Antibodies Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Axon Guidance and Neuronal Signaling
- Colorectal Cancer Treatments and Studies
- Carbon Nanotubes in Composites
- Bone health and treatments
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related gene regulation
Lund University
2015-2025
Malmö University
2024
University of Patras
2009-2016
Foundation for Research and Technology Hellas
2012-2014
FORTH Institute of Chemical Engineering Sciences
2012-2014
Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 (CSMD1) can regulate activity in vitro, expressed the brain, associated with increased schizophrenia risk. Beyond this, little known about CSMD1 including whether it regulates brain or otherwise plays a role neurodevelopment. We used biochemical, immunohistochemical, proteomic techniques to examine regional, cellular,...
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically alternative complement pathway, is activated in patients with carotid atherosclerosis related adverse outcome these patients, are scarce. Methods Results We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), H advanced a Discovery (n=324) Validation (n=206) cohort relation (mean follow‐up 7.8 6.6 years, respectively). Our major...
Abstract Background To identify subjects with rupture-prone atherosclerotic plaques before thrombotic events occur is an unmet clinical need. Thus, this proof-of-concept study aims to determine which plaque features can be detected using clinically available photon-counting computed tomography (PCCT). Methods In retrospective study, advanced ( ex vivo , paraffin-embedded) from the Carotid Plaque Imaging Project were scanned by PCCT reconstructed energy levels (45, 70, 120, 190 keV). Density...
The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable receptor and more stable analogue FOL-026. X-ray diffraction microscale thermophoresis analysis revealed that FOL-026 shares binding site with VEGF in NRP-1 b1-subdomain. Stimulation of human umbilical vein cells resulted phosphorylation VEGFR-2,...
Estradiol (E2)-estrogen receptor (ER) actions are implicated in initiation, growth and progression of hormone-dependent breast cancer. Crosstalk between ERs, epidermal factor (EGFR) and/or insulin-like (IGFR) is critical for the observed resistance to endocrine therapies. Cell surface heparan sulfate proteoglycans (HSPGs) principal mediators cancer cell properties E2-ER pathway as well those activated by EGFR IGFR have significant roles regulating expression certain HSPGs, such syndecan-2...
Cell surface heparan sulfate proteoglycans ( HSPG s), syndecans and glypicans, play crucial roles in the functional properties of cancer cells, such as proliferation, adhesion, migration invasion. Platelet‐derived growth factor PDGF )/ receptor ‐R) mediated signaling, on other hand, is highly associated with progression. Specifically, ‐Rα ‐Rβ expressions documented breast tissue specimens well cell lines are correlated tumor aggressiveness metastasis. Imatinib (Glivec ® ) a tyrosine kinase...
Human CUB and Sushi multiple domains 1 (CSMD1) is a membrane-bound complement inhibitor suggested to act as putative tumor suppressor gene, since allelic loss of this region encompassing 8p23 including CSMD1 characterizes various malignancies. Here, we assessed the role gene in development breast cancer vitro vivo. We found that human tissues expressed at lower levels compared normal mammary tissues. The decreased expression was linked shorter overall survival patients. also revealed cells...
Atherosclerosis progresses from fatty streaks to complex plaques, with rupture leading life-threatening complications. Endothelial-to-mesenchymal transition (EndMT) is associated advanced atherosclerotic but its role in plaque progression remains unclear. To investigate this, we analyzed the of TWIST1, a key EndMT- driving transcription factor, development. Using single-cell RNA sequencing plaques hypercholesterolemic mice inducible deletion Twist1 endothelial cells (Twist1ECKO ApoE-/-)...
Abstract Schizophrenia risk is associated with increased gene copy number and brain expression of complement component 4 ( C4 ). Because the system facilitates synaptic pruning, association has renewed interest in a hypothesis that excessive pruning contributes to schizophrenia pathogenesis. However, little known about regulation neural tissues or whether such could be relevant psychiatric illness. Intriguingly, common variation within CSMD1 , which encodes putative inhibitor, consistently...
Introduction Cartilage Oligomeric Matrix Protein (COMP) is an oncogenic protein that has been associated with a decrease in infiltrating T-cells periampullary adenocarcinoma. This study aimed to investigate whether this also the case for colorectal cancer (CRC) and evaluate relationship between COMP expression clinopathological features. Methods Immunohistochemistry was used determine levels of tumor cells stroma primary tumors from cohort 537 CRC patients. The immune cell markers, including...