A5001179545- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Advanced X-ray and CT Imaging
- Cardiac Imaging and Diagnostics
- Artificial Intelligence in Healthcare and Education
- Cerebrovascular and Carotid Artery Diseases
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- COVID-19 diagnosis using AI
- CAR-T cell therapy research
- Advanced MRI Techniques and Applications
- Radiation Dose and Imaging
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Advanced Radiotherapy Techniques
- Lung Cancer Diagnosis and Treatment
- Bone health and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Radiology practices and education
- Orthopedic Infections and Treatments
- Cardiovascular Disease and Adiposity
Society of Nuclear Medicine and Molecular Imaging
2024-2025
National Institutes of Health
2020-2025
National Institute of Dental and Craniofacial Research
2024-2025
Molecular Theranostics (United States)
2024-2025
Emory University
2025
University of Alabama at Birmingham
2025
Johns Hopkins University
2022-2025
University of Pennsylvania
2010-2024
National Institutes of Health Clinical Center
2020-2024
Hospital of the University of Pennsylvania
2011-2023
CD40 immunotherapy shows efficacy in treating pancreatic cancer mice and humans by eliciting antitumor immunity.
This phase I study investigated the maximum-tolerated dose (MTD), safety, pharmacodynamics, immunologic correlatives, and antitumor activity of CP-870,893, an agonist CD40 antibody, when administered in combination with gemcitabine patients advanced pancreatic ductal adenocarcinoma (PDA).Twenty-two chemotherapy-naïve PDA were treated 1,000 mg/m(2) once weekly for three weeks infusion CP-870,893 at 0.1 or 0.2 mg/kg on day each 28-day cycle.CP-870,893 was well-tolerated; one dose-limiting...
Abstract The T cell receptor fusion construct (TRuC) gavocabtagene autoleucel (gavo-cel) consists of single-domain anti-mesothelin antibody that integrates into the endogenous (TCR) and engages signaling capacity entire TCR upon mesothelin binding. Here we describe phase 1 results from an ongoing phase1/2 trial gavo-cel in patients with treatment-refractory mesothelin-expressing solid tumors. primary objectives were to evaluate safety determine recommended 2 dose (RP2D). Secondary included...
Abstract Background The utility of fluorodeoxyglucose positron emission tomography (FDG‐PET) imaging in Alzheimer's disease (AD) diagnosis has been well established. Recently, measurement cerebral blood flow using arterial spin labeling magnetic resonance (ASL‐MRI) shown diagnostic potential AD, although it never directly compared with FDG‐PET. Methods We used a novel protocol to obtain FDG‐PET and ASL‐MRI images concurrently 17 AD patients 19 age‐matched control subjects. Paired from...
Nanomedicine is emerging as a promising approach for diagnostic applications. Nanoparticles are structures in the nanometer size range, which can present different shapes, compositions, charges, surface modifications, vitro and vivo stabilities, performances. be made of materials diverse chemical nature, most common being metals, metal oxides, silicates, polymers, carbon, lipids, biomolecules. exist various morphologies, such spheres, cylinders, platelets, tubes. Radiolabeled nanoparticles...
Chest radiography is the most common diagnostic imaging examination performed in emergency departments (EDs). Augmenting clinicians with automated preliminary read assistants could help expedite their workflows, improve accuracy, and reduce cost of care.To assess performance artificial intelligence (AI) algorithms realistic radiology workflows by performing an objective comparative evaluation reads anteroposterior (AP) frontal chest radiographs AI algorithm residents.This study included a...
The nuclear medicine field has seen a rapid expansion of academic and commercial interest in developing artificial intelligence (AI) algorithms. Users developers can avoid some the pitfalls AI by recognizing following best practices algorithm development. In this article, recommendations on technical for algorithms are provided, beginning with general then continuing descriptions how one might practice these principles specific topics within medicine. This report was produced Task Force...
An important need exists for strategies to perform rigorous objective clinical-task-based evaluation of artificial intelligence (AI) algorithms nuclear medicine. To address this need, we propose a 4-class framework evaluate AI promise, technical task-specific efficacy, clinical decision making, and postdeployment efficacy. We provide best practices each these classes. Each class yields claim that provides descriptive performance the algorithm. Key are tabulated as RELAINCE (Recommendations...
Radiopharmaceutical therapies are gaining increasing prominence as they improve survival in patients with common diseases such metastatic prostate cancer ([ 1 ][1],[ 2 ][2]). However, whereas sodium iodide (131I) therapy has been used for over 70 y treating malignant and benign thyroid
The deployment of artificial intelligence (AI) has the potential to make nuclear medicine and medical imaging faster, cheaper, both more effective accessible. This is possible, however, only if clinicians patients feel that these AI devices (AIMDs) are trustworthy. Highlighting need ensure health justice by fairly distributing benefits burdens while respecting individual patients’ rights, Task Force Society Nuclear Medicine Molecular Imaging identified 4 major ethical risks arise during...
Computational nuclear oncology for precision radiopharmaceutical therapy (RPT) is a new frontier theranostic treatment personalization. A key strategy relies on the possibility to incorporate clinical, biomarker, image-based, and dosimetric information in digital twins (TDTs) of patients move beyond one-size-fits-all approach. The TDT framework enables optimization by real-time monitoring real-world system, simulation different scenarios, prediction resulting outcomes, as well facilitating...
This study aims to assess and compare the value of FDG PET with combined In-labeled leukocyte/Tc-sulfur colloid bone marrow (WBC/BM) imaging for diagnosing infection in hip knee prostheses.In this prospective study, patients painful or arthroplasty, who were scheduled undergo clinical diagnostic evaluation prosthesis revision, included. They have been studied by using WBC/BM scan. was institutional review board approved Health Insurance Portability Accountability Act compliant. All provided...