A5077969822- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Neuroendocrine Tumor Research Advances
- AI in cancer detection
- Peptidase Inhibition and Analysis
- Lymphoma Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Monoclonal and Polyclonal Antibodies Research
- Radiation Therapy and Dosimetry
- Radioactive Decay and Measurement Techniques
- Lung Cancer Diagnosis and Treatment
- MRI in cancer diagnosis
- Mass Spectrometry Techniques and Applications
- Advanced Neural Network Applications
- Advanced MRI Techniques and Applications
- Medical Imaging and Pathology Studies
- Radiation Dose and Imaging
- CAR-T cell therapy research
- Medical Image Segmentation Techniques
- Artificial Intelligence in Healthcare and Education
- Radiation Detection and Scintillator Technologies
University of British Columbia
2015-2025
BC Cancer Agency
2018-2024
Molecular Oncology (United States)
2024
Cancer Research Institute
2024
Terry Fox Research Institute
2023
Occupational Cancer Research Centre
2023
Spinal Cord Injury BC
2019-2022
Adler Planetarium
2015
University of Illinois Chicago
2015
We designed and evaluated a novel albumin-binder-conjugated 177Lu-PSMA-617 derivative, 177Lu-HTK01169, with an extended blood retention time to maximize the radiation dose delivered prostate tumors expressing prostate-specific membrane antigen (PSMA). PSMA-617 HTK01169 that contained N-[4-(p-iodophenyl)butanoyl]-Glu as albumin-binding motif were synthesized using solid-phase approach. Binding affinity PSMA was determined by in vitro competition-binding assay. 177Lu labeling performed acetate...
Radiopharmaceutical therapies (RPTs) with <sup>177</sup>Lu-prostate-specific membrane antigen (PSMA) ligands have demonstrated promising results for the treatment of metastatic castration-resistant prostate cancer. The lack absorbed-dose–effect relationships currently prevents patient-specific activity personalization. To ease implementation dosimetry in routine clinical workflow RPT, simplified methods such as single-time-point (STP) instead multiple-time-point (MTP) imaging protocols are...
Computational nuclear oncology for precision radiopharmaceutical therapy (RPT) is a new frontier theranostic treatment personalization. A key strategy relies on the possibility to incorporate clinical, biomarker, image-based, and dosimetric information in digital twins (TDTs) of patients move beyond one-size-fits-all approach. The TDT framework enables optimization by real-time monitoring real-world system, simulation different scenarios, prediction resulting outcomes, as well facilitating...
The use of an albumin binder has been shown to improve tumor uptake prostate-specific membrane antigen (PSMA)-targeting radiotherapeutic agents. aim this study was develop improved agents that combine optimized affinity-modifying group and binders maximize the tumor-to-kidney absorbed dose ratio.
Because of challenges in performing routine personalized dosimetry radiopharmaceutical therapies, interest single-time-point (STP) dosimetry, particularly using only a single SPECT scan, is on the rise. Meanwhile, there are questions about reliability STP with limited independent validations. In present work, we analyzed 2 methods and evaluated dose errors for several radiopharmaceuticals based effective half-life distributions. <b>Methods:</b> We first challenged common assumption that...
Automatic and accurate segmentation of lesions in images metastatic castration-resistant prostate cancer has the potential to enable personalized radiopharmaceutical therapy advanced treatment response monitoring. The aim this study is develop a convolutional neural networks-based framework for fully-automated detection whole-body PET/CT images. 525 patients with were available study, acquired [18F]DCFPyL radiotracer that targets prostate-specific membrane antigen (PSMA). U-Net (1)-based...
Objectives: Accurate outcome prediction is important for making informed clinical decisions in cancer treatment. In this study, we assessed the feasibility of using changes radiomic features over time (Delta radiomics: absolute and relative) following chemotherapy, to predict relapse/progression progression (TTP) primary mediastinal large B-cell lymphoma (PMBCL) patients. Material Methods: Given lack standard staging PET scans until 2011, only 31 out 103 PMBCL patients our retrospective...
Image-based dosimetry-guided radiopharmaceutical therapy has the potential to personalize treatment by limiting toxicity organs at risk and maximizing therapeutic effect. The <sup>177</sup>Lu dosimetry challenge of Society Nuclear Medicine Molecular Imaging consisted 5 tasks assessing variability in workflow. fifth task investigated associated with last step, dose conversion, workflow on which this study is based. <b>Methods:</b> Reference was assessed 2 medical physicists using different...
The aim of the study is to assess accuracy activity quantification 177Lu studies performed according recommendations provided by committee on Medical Internal Radiation Dose (MIRD) pamphlets 23 and 26. performances two scatter correction three segmentation methods were compared. Additionally, tomographic planar for determination camera normalization factor (CNF) was evaluated. Eight phantoms containing inserts different sizes shapes placed in air, water, radioactive background scanned using...
Camera calibration, which translates reconstructed count map into absolute activity map, is a prerequisite procedure for quantitative SPECT imaging. Both planar and tomographic scans using different phantom geometries have been proposed the determination of camera calibration factor (CF). However, there no consensus on approach best. The aim this study to evaluate all these methods, compare their performance, propose practical accurate method quantitation therapeutic radioisotopes....
In this work, we present details and initial results from a <sup>177</sup>Lu dosimetry challenge that has been designed to collect data the global nuclear medicine community aiming at identifying, understanding, quantitatively characterizing consequences of various sources variability in dosimetry. <b>Methods:</b> The covers different approaches performing dosimetry: planar, hybrid, pure SPECT. It consists 5 independent tasks measure each step workflow. Each task involves calculation...
This work emphasizes that patient data, including images, are not operable (clinically), but digital twins are. Based on the former, latter can be created. Subsequently, virtual clinical operations performed towards selection of optimal therapies. Digital beginning to emerge in field medicine. We suggest theranostic (TDTs) amongst most natural and feasible flavors digitals twins. elaborate importance TDTs a future where 'one-size-fits-all' therapeutic schemes, as prevalent nowadays,...
Abstract Background Dosimetry after radiopharmaceutical therapy with 177 Lu ( Lu-RPT) relies on quantitative SPECT/CT imaging, for which suitable reconstruction protocols are required. In this study, we characterized the first time performance of a ring-shaped CZT-based camera using two different algorithms: an ordered subset expectation maximization (OSEM) and block sequential regularized (BSREM) combined noise reduction regularization. This study lays foundations definition protocol...
Image artefacts continue to pose challenges in clinical molecular imaging, resulting misdiagnoses, additional radiation doses patients and financial costs. Mismatch halo occur frequently gallium-68 (
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The gastrin-releasing peptide receptor (GRPR), a G protein-coupled receptor, is overexpressed in solid malignancies and particularly prostate cancer. We synthesized novel bombesin derivative, [68Ga]Ga-ProBOMB1, evaluated its pharmacokinetics potential to image GRPR expression with positron emission tomography (PET), compared it [68Ga]Ga-NeoBOMB1. ProBOMB1 (DOTA-pABzA-DIG-d-Phe-Gln-Trp-Ala-Val-Gly-His-Leu-ψ(CH2N)-Pro-NH2) was by solid-phase synthesis. polyaminocarboxylate chelator...