A5076399682- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Prostate Cancer Treatment and Research
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Advanced Breast Cancer Therapies
- Head and Neck Cancer Studies
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Surgical Treatments
- Bone health and treatments
Université Libre de Bruxelles
2016-2025
Institut Jules Bordet
2016-2025
Breast International Group
2013-2017
Committee on Publication Ethics
2017
Dana-Farber Cancer Institute
2017
Frontier Science & Technology Research Foundation
2017
Hospital of Prato
2017
International Breast Cancer Study Group
2017
Frontier Science Foundation
2017
Leefmilieu Brussel
2004-2016
PURPOSE: A prospective study of preoperative tumor-node-metastasis staging patients with esophageal cancer (EC) was designed to compare the accuracy 18-F-fluoro-deoxy-d-glucose (FDG) positron emission tomography (PET) conventional noninvasive modalities. PATIENTS AND METHODS: Seventy-four carcinomas esophagus (n = 43) or gastroesophageal junction 31) were studied. All underwent attenuation-corrected FDG-PET imaging, a spiral computed (CT) scan, and an endoscopic ultrasound (EUS). RESULTS:...
Liver dissemination is a major cause of mortality among patients with advanced colorectal cancer. Hepatic intra-arterial injection the beta-emitting isotope yttrium-90 ((90)Y) bound to resin microspheres (radioembolization) delivers therapeutic radiation doses liver metastases minimal damage adjacent tissues.We conducted prospective, multicenter, randomized phase III trial in unresectable, chemotherapy-refractory liver-limited metastatic CRC (mCRC) comparing arm A (fluorouracil [FU]...
•The clinical course of advanced cancer for many patients with bone metastases can be transformed through optimum multidisciplinary management.•Bone-targeted agents significantly reduce skeletal morbidity in across tumour types and should part standard treatment.•Treatment-induced loss increases fracture risk may require use a bone-targeted agent addition to lifestyle modifications.•The bisphosphonate adjuvant therapies postmenopausal early breast reduces recurrence improves survival.
Abstract Purpose A multidisciplinary expert panel convened to formulate state-of-the-art recommendations for optimisation of selective internal radiation therapy (SIRT) with yttrium-90 ( 90 Y)-resin microspheres. Methods steering committee 23 international experts representing all participating specialties formulated SIRT Y-resin microspheres activity prescription and post-treatment dosimetry, based on literature searches the responses a 61-question survey that was completed by 43 leading...
Primary liver tumours (i.e. hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICC)) are among the most frequent cancers worldwide. However, only 10-20% of patients amenable to curative treatment, such as resection transplant. Liver metastases frequently caused by colorectal cancer, which accounts for second cancer-related deaths in Europe. In both primary and secondary tumours, radioembolization has been shown be a safe effective treatment option. The vast potential...
Objective To assess the value of positron emission tomography with 18fluorodeoxyglucose (FDG-PET) for preoperative lymph node staging patients primary cancer esophagus and gastroesophageal junction. Summary Background Data FDG-PET appears to be a promising tool in Recent reports indicate higher sensitivity specificity detection stage IV disease diagnosis involvement compared standard use computed endoscopic ultrasound. Methods Forty-two entered prospective study. All underwent...
PURPOSE: To assess the additional value of whole-body [ 18 F]-2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) scan as a staging modality complementing conventional diagnostic methods (CDM) in patients suspected having recurrent colorectal adenocarcinoma. PATIENTS AND METHODS: In 103 patients, discordances between FDG-PET and CDM results were identified related to final diagnosis obtained by histopathology or clinical follow-up (> 1 year). All studies reviewed with full...
Selective internal radiotherapy (SIRT) using Yttrium-90 labeled resin microspheres is increasingly used for the radioembolization of unresectable liver metastases colorectal cancer (CRC). The treatment can be simulated by scintigraphy with Tc(99m)-labeled macroaggregates albumin (MAA). aim study was to develop a predictive dosimetric model SIRT and validate it correlating results metabolic response. simulation dosimetry performed mathematically converting all voxel MAA-SPECT uptake values...
Molecular imaging receives increased attention for selecting patients who will benefit from targeted anticancer therapies. Neo-ALTTO (Neoadjuvant Lapatinib and/or Trastuzumab Treatment Optimisation) enrolled 455 women with invasive human epidermal growth factor receptor 2 (HER2)–positive breast cancer and compared rates of pathologic complete response (pCR) to neoadjuvant lapatinib, trastuzumab, their combination. Each anti-HER2 therapy was given alone 6 wk, followed by 12 wk the same plus...
To assess the impact of a novel molecular imaging technique, 68 Ga-(HBED-CC)-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT), in clinical management patients with prostate cancer rising prostate-specific (PSA) after treatment curative intent.In all, 131 consecutive were referred to our centre for Ga-PSMA PET/CT setting recurring cancer. Of these patients, 11/131(8%) presented persistent PSA radical prostatectomy, while 120/131 (92%)...
To compare using immuno-PET/CT the distribution of 89Zr-labelled rituximab without and with a preload unlabelled to assess impact preloading on tumour targeting radiation dose subsequent radioimmunotherapy 90Y-labelled in CD20+ B-cell lymphoma. Five patients lymphoma progressive disease were prospectively enrolled. All underwent three study phases: initial dosimetric phase baseline 89Zr-rituximab PET/CT imaging cold preload, followed 3 weeks later by second administration standard (250...
The prognostic value of body composition in cancer patients has been widely studied during the last decade. main finding these studies is that sarcopenia, or skeletal muscle depletion, assessed by CT imaging correlates with a reduced overall survival (OS). By contrast, fat mass remains ill-defined. This study aims to analyze influence including both and adipose tissue on OS homogeneous population advanced colorectal (CRC) patients.Among 235 chemorefractory CRC included SoMore RegARd-C...
Gastroenteropancreatic neuroendocrine neoplasms (GEPNENs) are heterogeneous in clinical course, biology, and outcomes. The NETPET score predicts survival by scoring uptake on dual [68Ga]DOTATATE [18F]FDG PET/CT scans. We aimed to validate previous single-centre findings a multicentre, international study.Dual scans were assigned of P1 (DOTATATE positive/FDG negative), P2-4 positive), or P5 negative/FDG positive). score, histological grade, age at diagnosis, presence/absence extrahepatic...
Our objective was to predict the outcome of peptide receptor radionuclide therapy (PRRT) using multimodality imaging and tumor dosimetry on gastroenteropancreatic neuroendocrine (GEP-NET) lesions patients.
Abstract Efficacy of the human epidermal growth factor receptor (HER)2-targeting trastuzumab emtansine (T-DM1) in breast cancer (BC) relies on HER2 status determined by immunohistochemistry or fluorescence in-situ hybridization. Heterogeneity expression, however, generates interest “whole-body” assessment using molecular imaging. We evaluated role HER2-targeted imaging detecting HER2-positive BC lesions and patients unlikely to respond T-DM1. Patients underwent zirconium-89 ( 89 Zr) (HER2)...
Patients with relapsed malignant glioma have a poor prognosis. We developed strategy of vaccination using autologous mature dendritic cells loaded tumour homogenate. In total, 12 patients median age 36 years (range: 11-78) were treated. All had relapsing glioma. After surgery, vaccines given at weeks 1 and 3, later every 4 weeks. A 5 2-7) was given. There no serious adverse events except in one patient gross residual prior to vaccination, who repetitively vaccine-related peritumoral oedema....