A5081437454- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Pleural and Pulmonary Diseases
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Atomic and Subatomic Physics Research
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Ultrasound in Clinical Applications
- Advanced X-ray and CT Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- COVID-19 diagnosis using AI
- Occupational and environmental lung diseases
- MRI in cancer diagnosis
- Respiratory viral infections research
- Pulmonary Hypertension Research and Treatments
- Lymphoma Diagnosis and Treatment
- Trauma Management and Diagnosis
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2010-2025
Weatherford College
2022
University of British Columbia
2016
St. Paul's Hospital
2016
HeidelbergCement (Germany)
2008
University Radiology
2008
Catholic University of America
2004
Justus-Liebig-Universität Gießen
1983
PURPOSE: A prospective study of preoperative tumor-node-metastasis staging patients with esophageal cancer (EC) was designed to compare the accuracy 18-F-fluoro-deoxy-d-glucose (FDG) positron emission tomography (PET) conventional noninvasive modalities. PATIENTS AND METHODS: Seventy-four carcinomas esophagus (n = 43) or gastroesophageal junction 31) were studied. All underwent attenuation-corrected FDG-PET imaging, a spiral computed (CT) scan, and an endoscopic ultrasound (EUS). RESULTS:...
Abstract How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL) samples from 5 patients with mild 26 critical in comparison BALs non-COVID-19 pneumonia normal lung. We use pseudotime inference build T-cell monocyte-to-macrophage trajectories model gene expression changes along them. In COVID-19, CD8 + resident-memory (T RM ) CD4...
Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the triggering of an aberrant host immune response, more so than on direct virus-induced cellular damage. To elucidate immunopathology underlying COVID-19 severity, we perform cytokine multiplex profiling in patients. We show hypercytokinemia differs from interferon-gamma-driven storm macrophage activation syndrome, is pronounced critical versus mild-moderate COVID-19. Systems modelling levels paired with...
Long-term outcome data of coronavirus disease 2019 (COVID-19) survivors are needed to understand their recovery trajectory and additional care needs.A prospective observational multicentre cohort study was carried out adults hospitalised with COVID-19 from March through May 2020. Workup at 3 12 months following admission consisted clinical review, pulmonary function testing, 6-min walk distance (6MWD), muscle strength, chest computed tomography (CT) quality life questionnaires. We evaluated...
Objective To assess the value of positron emission tomography with 18fluorodeoxyglucose (FDG-PET) for preoperative lymph node staging patients primary cancer esophagus and gastroesophageal junction. Summary Background Data FDG-PET appears to be a promising tool in Recent reports indicate higher sensitivity specificity detection stage IV disease diagnosis involvement compared standard use computed endoscopic ultrasound. Methods Forty-two entered prospective study. All underwent...
Mediastinal restaging after induction therapy for non-small-cell lung cancer remains a difficult and controversial issue. The goal of this prospective study was to compare the performance integrated positron emission tomography (PET)--computed (CT) remediastinoscopy in evaluation mediastinal lymph node metastasis chemotherapy.Thirty consecutive stage IIIA-N2 patients surgically treated at our institution were entered onto study. N2 disease proven by cervical mediastinoscopy, which mean...
Chronic lung allograft dysfunction (CLAD) remains the leading cause of mortality after transplantation.In this retrospective single-center study, we aimed to identify different phenotypes and risk factors for CLAD diagnosis using univariate multivariate Cox proportional hazard survival regression analysis.CLAD was diagnosed in 71 294 patients (24.2%) at 30.9±22.8 months transplantation. Pulmonary function obstructive 51 (71.8%) patients, restrictive 20 (28.2%) whom 17 had persistent...
Background Immune checkpoint inhibitor (ICI)-related pneumonitis is the most frequent fatal immune-related adverse event associated with programmed cell death protein-1/programmed ligand-1 blockade. The pathophysiology however remains largely unknown, owing to limited and contradictory findings in existing literature pointing at either T-helper 1 or 17-mediated autoimmunity. In this study, we aimed gain novel insights into mechanisms of ICI-related pneumonitis, thereby identifying potential...
Lung cancer is a common disease and leading cause of death in many countries. The management lung directed by an optimal staging the tumour. Integrated positron emission tomography (PET)/computed (CT) anatomo-metabolic imaging modality that has recently been introduced to clinical practice combines two different techniques: CT, which provides very detailed anatomic information; PET, metabolic information. One advantages PET/CT improved image interpretation. This improvement can result...
To evaluate retrospectively the accuracy of integrated PET/CT, against PET, CT, or conventional staging in breast cancer. Seventy consecutive biopsy proven clinical stage IIB and III cancer patients were included. Descriptive statistics PET/CT for primary tumor, nodal status metastasis detection compared to CT with contrast, (biochemistry, chest X-ray, liver ultrasound, bone scintigraphy). Sensitivity tumor was 97.1% 62.5%, respectively. Specificity negative predictive value 100% 66.6%, The...
To investigate the use of diffusion-weighted (DW) imaging for differentiating benign lesions from malignant pleural disease (MPD) and to retrospectively assess dynamic contrast material-enhanced (DCE) magnetic resonance (MR) acquisitions find out whether combining these measurements with DW could improve diagnostic value imaging.This study was approved by local ethics committee, all patients provided written informed consent. Thirty-one consecutive abnormalities suspicious MPD underwent...
The crazy-paving pattern is a linear superimposed on background of ground-glass opacity, resembling irregularly shaped paving stones. initially described as the pathognomonic sign alveolar proteinosis. Nowadays this common finding high-resolution CT imaging, and can be seen in number acute chronic diseases. purpose paper to illustrate different diseases that cause correlate radiological findings from computed tomography with histopathological findings.
Purpose To elucidate the underlying lung changes responsible for computed tomographic (CT) features of idiopathic pulmonary fibrosis (IPF) and to gain insight into way IPF proceeds through lungs progresses over time. Materials Methods Micro-CT studies tissue cores obtained from explant were examined correlated 1:1 with a CT study immediately before transplantation. Samples histologic analysis selected cores. Results In areas no or minimal abnormalities on images, small increased attenuation...
Screening for lung cancer with low radiation dose computed tomography has a strong evidence base, is being introduced in several European countries and recommended as new targeted screening programme. The imperative now to ensure that implementation follows an evidence-based process will clinical cost effectiveness. This Respiratory Society (ERS) task force was formed provide expert consensus the management of incidental findings which can be adapted followed during implementation.
The aim of the present study was to assess retrospectively additional value positron emission tomography (PET)/computed (CT) in detection unexpected extrapulmonary lesions staging patients with a malignant pulmonary lesion comparison CT and PET used alone. A total 217 pathologically proven lung tumour underwent PET/CT. CT, PET/CT were evaluated lesions. These abnormalities compared final diagnosis obtained from medical records statistical analysis carried out. In total, 108 clinically...