A5047759445- Cancer-related Molecular Pathways
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Hippo pathway signaling and YAP/TAZ
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Cell death mechanisms and regulation
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Advanced biosensing and bioanalysis techniques
- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
- Myasthenia Gravis and Thymoma
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Telomeres, Telomerase, and Senescence
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2025
Istituti Fisioterapici Ospitalieri
2011-2025
Cancer Institute (WIA)
2003-2025
McMaster University
2014-2024
National Cancer Institute
2012-2024
Juravinski Cancer Centre
2015-2024
Fondazione IRCCS Istituto Nazionale dei Tumori
2020-2024
Tel Aviv University
2023
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2023
University of Brescia
2023
Specific protein-protein interactions are involved in a large number of cellular processes and mainly mediated by structurally functionally defined domains. Here we report that the nuclear phosphoprotein p73 can engage physical association with Yes-associated protein (YAP). This occurs under physiological conditions as shown reciprocal co-immunoprecipitation complexes from lysates P19 cells. The WW domain YAP PPPPY motif directly association. Furthermore, required for ligands to group I...
Highlights•Multi-omics definition of four robust molecular TET subtypes associated with survival•Thymomas have the lowest mutational burden among adult cancers•Enrichment HRAS, NRAS, TP53, and recurrent GTF2I mutations are observed•Expression autoimmune targets aneuploidy links thymoma to myasthenia gravisSummaryThymic epithelial tumors (TETs) one rarest malignancies. Among TETs, is most predominant, characterized by a unique association diseases, followed thymic carcinoma, which less common...
Circular RNAs are a class of endogenous with various functions in eukaryotic cells. Worthy note, circular play critical role cancer. Currently, nothing is known about their head and neck squamous cell carcinoma (HNSCC). The identification HNSCC might become useful for diagnostic therapeutic strategies HNSCC. Using samples from 115 patients, we find that circPVT1 over-expressed tumors compared to matched non-tumoral tissues, particular enrichment patients TP53 mutations. up- down-regulation...
Literature data suggests that age, gender and body mass index (BMI) could be associated with difference in immune responses to vaccines. The first goal of the study was analyze antibody titre seven days after second dose BNT162b2 vaccine a group 248 healthcare workers (HCWs). how changes correlation gender, BMI hypertension.An immunogenicity evaluation carried out among HCWs vaccinated at Istituti Fisioterapici Ospitalieri (IFO), Rome, Italy. All were asked by Italian national campaign...
Melatonin is an indolic hormone that regulates a plethora of functions ranging from the regulation circadian rhythms and antioxidant properties to induction maintenance tumor suppressor pathways. It binds specific receptors as well some cytosolic proteins, leading several cellular signaling cascades. Recently, involvement melatonin in cancer insurgence progression has clearly been demonstrated. In this review, we will first describe structure its receptors, then discuss both molecular...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the system can progress to a multisystemic disease with aberrant inflammatory response. Cellular senescence promotes chronic inflammation, named senescence-associated secretory phenotype (SASP). We investigated whether 2019 (COVID-19) is associated cellular and SASP.Autopsy lung tissue samples from 11 COVID-19 patients 43 age-matched non-COVID-19 controls similar comorbidities were analysed by immunohistochemistry for...
p53 is the most frequently inactivated tumor suppressor gene in human cancer, whereas its homologue, p73, rarely mutated. Similarly to p53, p73 can promote growth arrest or apoptosis when overexpressed certain p53-null cells. It has previously been shown that some tumor-derived mutants exert gain of function activity. The molecular mechanism underlying this activity remains be elucidated. We show here (p53His175 and p53Gly281) associate vitro andin vivo with p73α, β, γ, δ. This association...
The p53 tumor suppressor gene is the most frequent target for genetic alterations in human cancers, whereas recently discovered homologues p73 and p63 are rarely mutated. We others have previously reported that tumor-derived mutants can engage a physical association with different isoforms of p73, inhibiting their transcriptional activity. Here, we report associate <i>in vitro</i> vivo</i> through respective core domains. show interaction mutant impairs sequence-specific DNA binding...