A5075254077- Telomeres, Telomerase, and Senescence
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Galectins and Cancer Biology
- Radiation Therapy and Dosimetry
- Autophagy in Disease and Therapy
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Prostate Cancer Treatment and Research
- Tryptophan and brain disorders
- Cell Adhesion Molecules Research
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- COVID-19 Clinical Research Studies
- Effects of Radiation Exposure
- melanin and skin pigmentation
- Redox biology and oxidative stress
- Sirtuins and Resveratrol in Medicine
- Mechanisms of cancer metastasis
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- Inflammasome and immune disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
National and Kapodistrian University of Athens
2016-2025
Anna Needs Neuroblastoma Answers
2020
University of Thessaly
2020
City Of Hope National Medical Center
2020
St. Jude Children's Research Hospital
2020
St.Petersburg V.M.Bekhterev Psychoneurological Research Institute
2013
Eginition Hospital
1997-2000
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of the system can progress to a multisystemic disease with aberrant inflammatory response. Cellular senescence promotes chronic inflammation, named senescence-associated secretory phenotype (SASP). We investigated whether 2019 (COVID-19) is associated cellular and SASP.Autopsy lung tissue samples from 11 COVID-19 patients 43 age-matched non-COVID-19 controls similar comorbidities were analysed by immunohistochemistry for...
Myelination results in a highly segregated distribution of axonal membrane proteins at nodes Ranvier. Here, we show the role this process TAG-1, glycosyl-phosphatidyl-inositol–anchored cell adhesion molecule. In absence Caspr2 did not accumulate juxtaparanodes, and normal enrichment shaker-type K+ channels these regions was severely disrupted, central peripheral nervous systems. contrast, localization protein 4.1B, an axoplasmic partner Caspr2, only moderately altered. which is expressed...
To describe the placental pathology, fetal autopsy findings and clinical characteristics of pregnancies that resulted in stillbirth owing to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) placentitis, identify potential risk factors.This was a prospective multicenter study non-vaccinated pregnant women affected by disease 2019 (COVID-19) Greece from April 2020 August 2021. A total 165 placentas were examined histologically six cases associated with SARS-CoV-2 placentitis...
Given the clinical, economic, and societal impact of obesity, unraveling mechanisms adipose tissue expansion remains fundamental significance. We previously showed that white (WAT) levels 3-mercaptopyruvate sulfurtransferase (MPST), a mitochondrial cysteine-catabolizing enzyme yields pyruvate sulfide species, are downregulated in obesity. Here, we report Mpst deletion results fat accumulation mice fed high-fat diet (HFD) through transcriptional metabolic maladaptation. Mpst-deficient on HFD...
Objectives Age is the strongest risk factor of giant cell arteritis (GCA), implying a possible pathogenetic role cellular senescence. To address this question, we applied an established senescence specific multimarker algorithm in temporal artery biopsies (TABs) GCA patients. Methods 75(+) TABs from patients, 22(−) polymyalgia rheumatica (PMR) patients and 10(−) non-GCA/non-PMR were retrospectively retrieved analysed. Synovial tissue specimens with inflammatory arthritis aorta used as...
Prostate cancer is a major cause of morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective early-stage androgen-sensitive disease, but prostate gradually develops into an androgen-resistant metastatic state the vast majority patients. According to our oncogene-induced model for development, senescence tumor progression barrier. However, whether implicated highly aggressive castration-resistant (CRPC) remains poorly addressed.Androgen-dependent...
The ozone layer in the Earth's atmosphere filters solar radiation and limits unwanted effects on humans. A depletion of this shield would permit hazardous levels UV radiation, especially UVB range, to bombard surface, resulting potentially significant human health. concern for these adverse intensifies if we consider that is combined with secondary cosmic (SCR) components, such as protons muons, well terrestrial gamma rays. This research aims delve into intricate interplay between earth at...
Abstract Background NUCKS (Nuclear, Casein Kinase and Cyclin-dependent Substrate) is a nuclear, DNA-binding highly phosphorylated protein. A number of reports show that expressed on the level mRNA in several human cancers, including breast cancer. In this work, expression both RNA protein levels was studied tissue biopsies consisted invasive carcinomas, intraductal proliferative lesions, benign epithelial proliferations fibroadenomas, as well primary cultures derived from above biopsies....
The combined effects of ionizing radiation (IR) with high-z metallic nanoparticles (NPs) such as gold has developed a growing interest over the recent years. It is currently accepted that radiosensitization not only attributed to physical but also underlying chemical and biological mechanisms’ contributions. Low- high-linear energy transfer (LET) IRs produce DNA damage different structural types. combination IR may increase clustering deposition events in vicinity NPs due production mainly...
The emerging field of senolytics is centered on eliminating senescent cells to block their contribution the progression age-related diseases, including cancer, and facilitate healthy aging. Enhancing selectivity senolytic treatments toward stands reduce adverse effects associated with existing interventions. Taking advantage lipofuscin accumulation in cells, we describe here development a highly efficient platform consisting lipofuscin-binding domain scaffold, which can be conjugated drug...
Integrins are transmembrane adhesion receptors that provide the physical link between actin cytoskeleton and extracellular matrix. It has been well established integrins play a major role in various cancer stages, such as tumor growth, progression, invasion metastasis. In breast cancer, integrin alphavbeta3 associated with high malignant potential cells, signaling onset of widespread Many preclinical studies based on cell lines, which may not represent behavior phenotype primary origin, due...
Pancreatic ductal adenocarcinoma (PDAC) is resistant to single-agent immunotherapies. To understand the mechanisms leading poor response this treatment, a better understanding of PDAC immune landscape required. The present work aims study profile in relationship spatial heterogeneity tissue microenvironment (TME) intact tissues.Serial section and multiplex situ analysis were performed 42 samples assess gene protein expression at single-cell resolution the: (a) tumor center (TC), (b) invasive...
Abstract Background Few published data, concerning the electron microscopy findings of idiopathic guttate hypomelanosis have been so far. Objectives To reveal microscopic and their aetiopathogenetic associations. Methods Punch biopsy specimens from four patients with hypomelanosis, after being properly processed, were observed under microscope. Results In epidermis, melanocytes melanosomes normal in structure. some areas, there was a reduced uptake by keratinocytes. dermis, fibroblasts...
Silymarin-enriched extract (SEE) is obtained from Silybum marianum (Asteraceae). Doxorubicin (DXR) a widely used chemotherapeutical yet with severe side effects. The goal of the present study was to assess pharmacologic effect SEE and its bioactive components silibinin silychristine when administrated alone or in combination DXR human prostate cancer cells (PC-3). PC-3 were treated SEE, (silybins A B), silychristine, alone, DXR, cell proliferation assessed by MTT assay. Cell cycle,...