A5048755230- Bone health and treatments
- Synthesis and biological activity
- Bone health and osteoporosis research
- Nutrition and Health in Aging
- Salivary Gland Disorders and Functions
- Prostate Cancer Treatment and Research
- Bone Metabolism and Diseases
- Exercise and Physiological Responses
- Sports Performance and Training
- Adenosine and Purinergic Signaling
- Obstructive Sleep Apnea Research
- Eating Disorders and Behaviors
- Cancer, Lipids, and Metabolism
- Bone and Joint Diseases
- Cancer Diagnosis and Treatment
- Nutritional Studies and Diet
- Endoplasmic Reticulum Stress and Disease
- Fatty Acid Research and Health
- Cardiovascular and exercise physiology
- Quinazolinone synthesis and applications
- Autophagy in Disease and Therapy
- Synthesis and Characterization of Heterocyclic Compounds
- Bioactive Compounds and Antitumor Agents
- Synthesis and Biological Evaluation
- Radiopharmaceutical Chemistry and Applications
Harokopio University of Athens
2015-2024
Columbia University Irving Medical Center
2020
General-Maternity District Hospital Helena Venizelou
2009
National and Kapodistrian University of Athens
2002-2008
Regulation of food intake is a recently identified endocrine function bone that mediated by Lipocalin-2 (LCN2). Osteoblast-secreted LCN2 suppresses appetite and decreases fat mass while improving glucose metabolism. We now show serum levels correlate with insulin β-cell function, indices healthy metabolism, in obese mice obese, prediabetic women. However, also body index resistance the same individuals are increased mice. To dissect this apparent discrepancy, we modulated Silencing Lcn2...
The aim of this study was to examine the levels endoplasmic reticulum (ER) stress in minor salivary glands, investigate interplay between ER stress-induced autophagy and apoptosis human gland (HSG) cells test effect on cellular redistribution two major Sjögren's syndrome (SS) autoantigens Ro/Sjögren's syndrome-related antigen A (SSA) La/Sjögren's B (SSB). Minor biopsies from SS patients sicca controls were examined by immunohistochemistry for expression 78 kDa glucose-regulated...
Levosimendan (LEVO) a clinically-used inodilator, exerts multifaceted cardioprotective effects. Case-studies indicate protection against doxorubicin (DXR)-induced cardiotoxicity, but this effect remains obscure. We investigated the and mechanism of different regimens levosimendan on sub-chronic chronic cardiotoxicity.Based preliminary in vivo experiments, rats serving as model doxorubicin-cardiotoxicity were divided into: Control (N/S-0.9%), DXR (18 mg/kg-cumulative), DXR+LEVO (LEVO, 24...
Myosteatosis implies impaired muscle quality. The aim of the study was to investigate association myosteatosis with other abnormalities and its role in prognosis liver cirrhosis (LC).Skeletal index (SMI) were measured by computed tomography. defined as radiodensity evaluated according dry body mass (BMI). Median values interquartile range used for continuous count (percentage) categorical variables.A total 197 consecutive patients included (age 61 (IQR 52-68); 67% male; MELD score 11...
Beta-glucan rich mushrooms may exert beneficial<italic>in vitro</italic>effects on bone physiology by alterations in the gut microbiota and/or SCFAs.
Resveratrol, a naturally occurring stilbene, exhibits numerous beneficial health effects. Various studies have demonstrated its diverse biological actions, including anti-oxidant, anti-inflammatory, and anti-platelet properties, thereby supporting potential for cardio protection, neuroprotection, anti-cancer activity. However, significant limitation of resveratrol is weak bioavailability. To overcome this challenge, multiple research groups investigated the synthesis new derivatives to...
Primary Sjögren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltrates associated with destruction of salivary gland epithelial cells (SGECs) induced mainly apoptosis. Adiponectin immunoregulatory hormone. We have previously shown that SGECs from patients primary SS as well controls differentially express adiponectin. derived constitutively produce and secrete adiponectin in higher quantities. The aim this study was to investigate the effect on proliferation...
In patients with liver cirrhosis (LC), sarcopenia is correlated frequent complications and increased mortality. Myostatin, a myokine, potential biomarker of skeletal mass and/or sarcopenia. The aim this study was to examine the association between myostatin muscle evaluate as in LC. Skeletal index (SMI) myosteatosis were evaluated by computed tomography scan. Muscle quantity quality along strength function used diagnose Serum measured ELISA. One hundred fifteen consecutive LC [72.2% male,...
Small bowel preparation for capsule endoscopy remains controversial. This study was conducted to compare the efficacy of 2 and 4 l polyethylene glycol.One hundred one patients (group A) received 100 B) in a prospective, randomized single-blind trial. To objectively evaluate enteric preparation, cleansing coefficient calculated each patient.The two groups were found comparable regarding age, sex, body mass index, reason referral. In 82 group A 76 B, examination small completed (P =0.40)....
Obstructive sleep apnea (OSA) and the metabolic syndrome (MetS) frequently coexist. Low serum vitamin D has been positively associated with OSA presence severity; however, data on its link to cardiometabolic features in patients remain scarce. We aimed assess 25-hydroxyvitamin [25(OH)D] explore association parameters OSA.This was a cross-sectional study among 262 (49 ± 9 years old, 73% men) polysomnography-diagnosed OSA. Participants were evaluated terms of anthropometric indices, lifestyle...
Prostate cancer is the second most commonly diagnosed in men worldwide, which almost incurable, once it progresses into metastatic stage. Adriamycin (ADR) a known chemotherapeutic agent that causes severe side effects. In recent years, studies natural plant products have revealed their anticancer activities. particular, Glycyrrhiza glabra enhanced extract (GGE), as licorice, has been reported to exert antiproliferative properties against cells. this study, cytotoxic potential of GGE was...
Silymarin-enriched extract (SEE) is obtained from Silybum marianum (Asteraceae). Doxorubicin (DXR) a widely used chemotherapeutical yet with severe side effects. The goal of the present study was to assess pharmacologic effect SEE and its bioactive components silibinin silychristine when administrated alone or in combination DXR human prostate cancer cells (PC-3). PC-3 were treated SEE, (silybins A B), silychristine, alone, DXR, cell proliferation assessed by MTT assay. Cell cycle,...
Abstract OBJECTIVES We analyzed the actions of zoledronic acid (10–250 μM) and doxorubicin nM) on PC‐3 prostate cancer cells using both continuous (48–96 hr) pulsatile exposures (15 min/day for up to three consecutive days). RESULTS The proliferation was inhibited by either or in a dose‐dependent manner. In contrast, failed inhibit growth cells. addition, inhibition partially neutralized exogenous administration geranylgeranyl pyrophosphate (GGPP), however, not farnesyl (FPP). Furthermore,...
Bone metastasis microenvironment-related growth factors such as insulin-like factor 1 (IGF-1), transforming beta (TGF-β1), basic fibroblast (bFGF) and interleukin 6 (IL-6) show survival activity, thereby inhibiting chemotherapy-induced apoptosis of PC-3 prostate cancer cells in vitro. Recently, zoledronic acid has been shown to induce while overexpression parathyroid hormone-related protein (PTHrP) inhibits serum deprivation-induced cells. Consequently, we have investigated whether IGF-1,...