A5089131063- COVID-19 Clinical Research Studies
- Diabetes and associated disorders
- Diabetes Management and Research
- Lipoproteins and Cardiovascular Health
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Parathyroid Disorders and Treatments
- Shoulder Injury and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Cancer, Lipids, and Metabolism
- Elbow and Forearm Trauma Treatment
- Venous Thromboembolism Diagnosis and Management
- Artificial Intelligence in Healthcare
- Peripheral Artery Disease Management
- Pituitary Gland Disorders and Treatments
- Systemic Lupus Erythematosus Research
- COVID-19 and healthcare impacts
- Ethics in Clinical Research
- Adrenal and Paraganglionic Tumors
- Cardiovascular Function and Risk Factors
- Foot and Ankle Surgery
- Machine Learning in Healthcare
Centre Hospitalier Universitaire de Nantes
2017-2025
Institut du Thorax
2017-2025
Inserm
2017-2025
Nantes Université
2020-2025
Centre National de la Recherche Scientifique
2019-2025
Centre d'Investigation Clinique de Nantes
2018-2022
Hôpital Paris Saint-Joseph
2022
Hôpital Robert-Debré
2021
Centre Hospitalier Universitaire de Reims
2021
Université de Reims Champagne-Ardenne
2021
Coronavirus disease-2019 (COVID-19) is a life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Diabetes has rapidly emerged as major comorbidity for COVID-19 severity. However, phenotypic characteristics of diabetes in patients are unknown. We conducted nationwide multicentre observational study people with hospitalised 53 French centres period 10–31 March 2020. The primary outcome combined tracheal intubation mechanical ventilation...
Abstract Aims/hypothesis This is an update of the results from previous report CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe outcomes prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). Methods The initiative a French nationwide multicentre study COVID-19 28-day follow-up. were screened after hospital admission 10 March April 2020. We mainly focused on discharge death within 28 days. Results included 2796...
Regulation of food intake is a recently identified endocrine function bone that mediated by Lipocalin-2 (LCN2). Osteoblast-secreted LCN2 suppresses appetite and decreases fat mass while improving glucose metabolism. We now show serum levels correlate with insulin β-cell function, indices healthy metabolism, in obese mice obese, prediabetic women. However, also body index resistance the same individuals are increased mice. To dissect this apparent discrepancy, we modulated Silencing Lcn2...
Abstract Aim To assess the relationship between body mass index (BMI) classes and early COVID‐19 prognosis in inpatients with type 2 diabetes (T2D). Methods From CORONAvirus‐SARS‐CoV‐2 Diabetes Outcomes (CORONADO) study, we conducted an analysis patients T2D categorized by four BMI subgroups according to World Health Organization classification. Clinical characteristics COVID‐19–related outcomes (i.e. intubation for mechanical ventilation [IMV], death discharge day 7 [D7]) were analysed...
Abstract Aims Risk stratification of sudden cardiac arrest (SCA) in Brugada syndrome (Brs) remains the main challenge for physicians. Several scores have been suggested to improve risk but never replicated. We aim investigate accuracy Brs scores. Methods and results A total 1613 patients [mean age 45 ± 15 years, 69% male, 323 (20%) symptomatic] were prospectively enrolled from 1993 2016 a multicentric database. All data described score double reviewed study. Among them, all evaluated with...
Abstract Objective Even though trimethylamine N-oxide (TMAO) has been demonstrated to interfere with atherosclerosis and diabetes pathophysiology, the association between TMAO major adverse cardiovascular events (MACE) not specifically established in type 2 (T2D). Research Design Methods We examined of plasma concentrations MACE all-cause mortality a single-center prospective cohort consecutively recruited patients T2D. Results The study population consisted 1463 SURDIENE participants (58%...
Abstract Aim To investigate the association between routine use of dipeptidyl peptidase‐4 (DPP‐4) inhibitors and severity coronavirus disease 2019 (COVID‐19) infection in patient with type 2 diabetes a large multicentric study. Materials Methods This study was secondary analysis CORONADO on 2449 patients (T2D) hospitalized for COVID‐19 68 French centres. The composite primary endpoint combined tracheal intubation mechanical ventilation death within 7 days admission. Stabilized weights were...
To evaluate the association of ulnar artery occlusion (UAO) assessed using Doppler ultrasound (DUS) with severity markers systemic sclerosis (SSc).Two hundred four unselected patients fulfilling American College Rheumatology/European League Against Rheumatism 2013 classification criteria for SSc were included in this cross-sectional multicenter study. All underwent bilateral hand DUS to presence UAO and clinical/paraclinical visceral evaluation according current guidelines. Univariable...
Background & aims In patients at metabolic risk, nonalcoholic fatty liver disease is a strong and highly prevalent predictor for type 2 diabetes. Its assessment in clinical practice not easy but the index (FLI) could be used as surrogate. Here, we studied association between FLI conversion to new-onset diabetes (NOD) or prediabetes reversion with prediabetes. Methods The IT-DIAB observational study included 389 individuals prediabetes, defined fasting plasma glucose (FPG) 110 125 mg/dL. NOD...
Objective Since 2014 Senegal has benefited from regular awareness-raising Short Message Service (SMS) campaigns (Be He@lthy, Be Mobile initiative) directed at people who have signed up, for free, to the ‘mDiabète’ programme. We report on an evaluation of its impact diabetes control. Design The clinical trial was designed send daily SMS during 3 months with type 2 diabetes. Due centre randomisation, were sent inclusion (M0) month (M3) in S and M3 6 (M6) P. Setting Medical northwestern suburbs...
Abstract Background Biomedical data warehouses (BDWs) have become an essential tool to facilitate the reuse of health for both research and decisional applications. Beyond technical issues, implementation BDWs requires strong institutional governance operational knowledge European national legal framework management access use. Objective In this paper, we describe compound process contents a regional university hospital BDW. Methods We present actions challenges regarding organizational...
Abstract Background Methylglyoxal (MGO) is a potent glycating agent that contributes to the pathogenesis of diabetes. However, MGO unstable in plasma without demanding sample preparation at blood collection, limiting its clinical utility as biomarker. We aimed discover reliable MGO-glycated albumin (ALB)-derived biomarkers and assess their association with new-onset diabetes (NOD) people prediabetes. Methods Bottom-up mass spectrometry-based proteomics was used peptide ALB, including...