A5043819281- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Radiation Detection and Scintillator Technologies
- Dark Matter and Cosmic Phenomena
- Atomic and Subatomic Physics Research
- Neutrino Physics Research
- Medical Imaging Techniques and Applications
- CCD and CMOS Imaging Sensors
- Black Holes and Theoretical Physics
- Computational Physics and Python Applications
- Particle Accelerators and Free-Electron Lasers
- Radiation Therapy and Dosimetry
- Nuclear physics research studies
- Advancements in Semiconductor Devices and Circuit Design
- Radiation Effects in Electronics
- Nuclear Physics and Applications
- Advanced Radiotherapy Techniques
- Astrophysics and Cosmic Phenomena
- Scientific Research and Discoveries
- Advanced NMR Techniques and Applications
- Analog and Mixed-Signal Circuit Design
- Analytical Chemistry and Sensors
- Cosmology and Gravitation Theories
University of Turin
2013-2025
Istituto Nazionale di Fisica Nucleare, Sezione di Torino
2016-2025
Institute of High Energy Physics
2018-2024
Budker Institute of Nuclear Physics
2024
China University of Geosciences
2024
Institute of Business Administration Karachi
2024
Carnegie Mellon University
2024
Chung-Ang University
2024
Ruhr University Bochum
2024
Central China Normal University
2024
Particle therapy exploits the energy deposition pattern of hadron beams. The narrow Bragg Peak at end range is a major advantage but uncertainties can cause severe damage and require online verification to maximise effectiveness in clinics. In-beam Positron Emission Tomography (PET) non-invasive, promising in-vivo technique, which consists measurement β+ activity induced by beam-tissue interactions during treatment, presents highest correlation measured distribution with deposited dose,...
A 64-channel ASIC for Time-of-Flight Positron Emission Tomography (TOF PET) imaging has been designed and simulated. The circuit is optimized the readout of signals produced by scintillation a L(Y)SO crystal optically coupled to silicon photomultiplier (SiPM). Developed in framework EndoTOFPET-US collaboration [1], integrated external PET plate performs timing, digitization data transmission 511 keV lower-energy events due Compton scattering.
We present a readout and digitization ASIC featuring low-noise low-power for time-of flight (TOF) applications using SiPMs. The circuit is designed in standard CMOS 110 nm technology, has 64 independent channels optimized time-of-flight measurement Positron Emission Tomography (TOF-PET). input amplifier low impedance current conveyor based on regulated common-gate topology. Each channel quad-buffered analogue interpolation TDCs (time binning 20 ps) charge integration ADCs with linear...
The quality assurance of particle therapy treatment is a fundamental issue that can be addressed by developing reliable monitoring techniques and indicators the plan correctness. Among available imaging techniques, positron emission tomography (PET) has long been investigated then clinically applied to proton carbon beams. In 2013, Innovative Solutions for Dosimetry in Hadrontherapy (INSIDE) collaboration proposed an innovative bimodal concept combines in-beam PET scanner with tracking...
In this contribution we will review the progresses toward construction of a tracking system able to measure passage charged particles with combined precision ∼10 ps and μm, either using single type sensor, concurrently position time, or combination time sensors.
Dark matter lighter than 10 GeV/c$^2$ encompasses a promising range of candidates. A conceptual design for new detector, DarkSide-LowMass, is presented, based on the DarkSide-50 detector and progress toward DarkSide-20k, optimized low-threshold electron-counting measurement. Sensitivity to light dark explored various potential energy thresholds background rates. These studies show that DarkSide-LowMass can achieve sensitivity down solar neutrino floor GeV-scale masses significant MeV/c$^2$...
Abstract Future liquid-argon DarkSide-20k and Argo detectors, designed for direct dark matter search, will be sensitive also to core-collapse supernova neutrinos, via coherent elastic neutrino-nucleus scattering. This interaction channel is flavor-insensitive with a high-cross section, enabling high-statistics neutrino detection target masses of ∼50 t ∼360 respectively. Thanks the low-energy threshold ∼0.5 keV nr achievable by exploiting ionization channel, have potential discover bursts...
We present the experimental characterization of TOFPET2, a readout and digitization ASIC for radiation detectors using Silicon Photomultipliers. The circuit is designed in CMOS 110 nm technology, has 64 independent channels optimized time-of-flight measurement PET or other applications. chip quad-buffered TDCs charge integration QDCs each channel. Coincidence Time Resolution (CTR) 511 keV photon pairs from 22Na point source measured with 2 × 3 mm3 LSO:Ce crystals co-doped 0.2% Ca 118 119 ps...
In particle therapy, the uncertainty of delivered range during patient irradiation limits optimization treatment planning. Therefore, an in vivo verification device is required, not only to improve plan robustness, but also detect significant interfractional morphological changes itself. this article, effective and robust analysis regions with a discrepancy proposed. This study relies on by means in-beam Positron Emission Tomography (PET) was carried out INSIDE system installed at National...
This article presents a fully depleted monolithic active pixel sensor technology compatible with standard deep submicrometer 110-nm CMOS process. Passive test pixels structures, produced in various flavors, have proved the feasibility of 100- and 300-μm-thick substrates. Active sensors monolithically integrated analog digital electronics, consisting 24 × array 50-μm pitch, been shown to be functional when operating full depletion mode. Characterization results obtained proton microbeam <sup...
The EndoTOFPET-US project aims to develop a multimodal detector foster the development of new biomarkers for prostate and pancreatic tumors. will consist two main components: an external plate, PET extension endoscopic ultrasound probe. plate is array LYSO crystals read out by silicon photomultipliers (SiPM) coupled Application Specific Integrated Circuit (ASIC). internal probe be highly integrated miniaturized made fully digital SiPM featuring photosensor elements readout in same chip....
Abstract Aria is a plant hosting $${350}\,\hbox {m}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>350</mml:mn><mml:mspace/><mml:mtext>m</mml:mtext></mml:mrow></mml:math> cryogenic isotopic distillation column, the tallest ever built, which being installed in mine shaft at Carbosulcis S.p.A., Nuraxi-Figus (SU), Italy. one of pillars argon dark-matter search experimental program, lead by Global Argon Dark Matter Collaboration. It was designed to reduce abundance...
Morphological changes that may arise through a treatment course are probably one of the most significant sources range uncertainty in proton therapy. Non-invasive in-vivo monitoring is useful to increase quality. The INSIDE in-beam Positron Emission Tomography (PET) scanner performs and carbon therapy treatments at National Center Oncological Hadrontherapy (CNAO). It currently clinical trial (ID: NCT03662373) has acquired PET data during various patients. In this work we analyze (IB-PET)...
Abstract DarkSide-20k is a novel liquid argon dark matter detector currently under construction at the Laboratori Nazionali del Gran Sasso (LNGS) of Istituto Nazionale di Fisica Nucleare (INFN) that will push sensitivity for Weakly Interacting Massive Particle (WIMP) detection into neutrino fog. The core apparatus dual-phase Time Projection Chamber (TPC), filled with 50 tonnes low radioactivity underground (UAr) acting as WIMP target. NUV-HD-cryo Silicon Photomultipliers (SiPM)s designed by...
Abstract DarkSide-20k (DS-20k) is a dark matter detection experiment under construction at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy. It utilises ∼ 100 t of low radioactivity argon from an underground source (UAr) its inner detector, with half serving as target dual-phase time projection chamber (TPC). The UAr cryogenics system must maintain stable thermodynamic conditions throughout experiment's lifetime over 10 years. Continuous removal impurities and radon essential for...
Abstract Objective: This paper introduces a novel PET imaging methodology called 3-dimensional positron (3DΠ), which integrates total-body (TB) coverage, time-of-flight (TOF) technology, ultra-low dose capabilities, and ultra-fast readout electronics inspired by emerging technology from the DarkSide collaboration. Approach: The study evaluates performance of 3DΠ using Monte Carlo simulations based on NEMA NU 2-2018 protocols. employs homogenous, monolithic scintillator composed liquid argon...
A 64-channel ASIC for TOF PET imaging is presented. The circuit provides time and energy measurements of events produced by a SiPM coupled to L(Y)SO fast scintillator. This developed in the framework EndoTOFPETUS collaboration as an option readout external 200×200 mm plate detector, which consists 3×3×15 crystals 3×3 (active area) SiPMs. Using chip with non-segmented and/or higher light yield possible. same applies photodetectors different gain, polarity, or even dark count rate. targeted...
Pixel detectors at HL-LHC experiments or other future are facing new challenges, especially in terms of unprecedented levels radiation and particle flux. This paper describes the progress made by CHIPIX65 project INFN for development a generation readout ASIC using CMOS 65 nm technology.
This paper is a review of recent progress RD53 Collaboration. Results obtained on the study radiation effects 65 nm CMOS have matured enough to define first strategies adopt in design analog and digital circuits. Critical building blocks very front end chains been designed, tested before after 5–800 Mrad. Small prototypes 64×64 pixels with complex architectures produced, point address main issues dealing extremely high pixel rates, while operating at small in-time thresholds end. The...