A5100337707- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Plant-Microbe Interactions and Immunity
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Plant Pathogens and Fungal Diseases
- Cancer Mechanisms and Therapy
- Agriculture Sustainability and Environmental Impact
- Plant responses to water stress
- Horticultural and Viticultural Research
- Atmospheric and Environmental Gas Dynamics
- Mitochondrial Function and Pathology
- Soil and Water Nutrient Dynamics
- Phytochemistry and biological activity of medicinal plants
- Plant tissue culture and regeneration
- Circular RNAs in diseases
- Protein Hydrolysis and Bioactive Peptides
- RNA and protein synthesis mechanisms
- Plant nutrient uptake and metabolism
- Histone Deacetylase Inhibitors Research
- Genomics and Phylogenetic Studies
- Trace Elements in Health
- Angiogenesis and VEGF in Cancer
- Chromosomal and Genetic Variations
- Legume Nitrogen Fixing Symbiosis
Zhejiang University
2014-2025
Sir Run Run Shaw Hospital
2021-2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2025
Shanxi University
2022-2025
Sanya University
2024
Wuhan University of Technology
2024
China-Japan Friendship Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Chongqing Normal University
2021-2024
The ataxia telangiectasia mutated (ATM) protein kinase plays a central role in the cellular response to DNA damage. Loss or inactivation of both copies ATM gene leads telangiectasia, devastating childhood condition characterized by neurodegeneration, immune deficiencies, and cancer predisposition. is also absent approximately 40% mantle cell lymphomas (MCLs), we previously showed that MCL lines with loss are sensitive poly-ADP ribose polymerase (PARP) inhibitors. Next-generation sequencing...
Fatty acids (FAs) are essential building blocks for all the domains of life, which bacterial de novo synthesis, called type II FA synthesis (FAS II), is energetically expensive. The recycling exogenous FAs (eFAs) partially relieves FAS demand and, therefore, compromises efficacy II-directed antimicrobials. versatile acyl-acyl carrier protein (ACP) synthetase, AasS, enables channeling diverse eFA nutrients through holo-ACP, an activated form ACP. However, molecular mechanism AasS catalysis...
The fungus Harpophora oryzae is a close relative of the pathogen Magnaporthe and beneficial endosymbiont wild rice. Here, we show that H. evolved from pathogenic ancestor. overall genomic structures M. were found to be similar. However, during interactions with rice, expression 11.7% all genes showed opposing trends in two fungi, suggesting differences gene regulation. Moreover, infection patterns, triggering host defense responses, signal transduction nutritional preferences exhibited...
A compound that reduces the prevalence of perinucleolar compartment in cancer cells inhibits metastasis vivo.
The advent of single-cell sequencing opened a new era in transcriptomic and genomic research. To understand cell composition using studies, variety markers have been widely used to label individual types. However, the specific database for use by plant research community remains very limited. overcome this problem, we developed Plant Cell Marker DataBase (PCMDB, http://www.tobaccodb.org/pcmdb/), which is based on uniform annotation pipeline. By manually curating over 130 000 publications,...
Experimental autoimmune encephalomyelitis (EAE) is characterized by demyelination of the central nervous system. Emodin an anthraquinone derivative with comprehensive anti-inflammatory, anti-cancer, and immunomodulatory effects widely used in treatment inflammatory, tumor, immune system diseases. However, none clinical or experimental studies have explored therapeutic efficacy emodin EAE/multiple sclerosis (MS). Thus, we evaluated protective effect on EAE mediated via inhibition microglia...
Abstract The rice endophyte Harpophora oryzae shares a common pathogenic ancestor with the blast fungus Magnaporthe . Direct comparison of interactions between single plant species and two closely-related (1) (2) mutualistic fungi can improve our understanding evolution plants that lead to either or interactions. Differences in metabolome transcriptome response challenge by H. M. were investigated GC-MS, RNA-seq qRT-PCR. Levels metabolites shikimate lignin biosynthesis pathways increased...
Bioactive peptides exhibiting angiotensin-converting enzyme (ACE) inhibitory effects and extracted from natural foods have potential as healthy safe therapeutics for high blood pressure. The aim of this study was to isolate purify ACE rabbit meat protein hydrolysate, explore the underlying mechanisms by molecular docking, evaluate antihypertensive in vivo. A novel tetrapeptide Trp-Gly-Ala-Pro (WGAP) identified purified a bromelain hydrolysate. WGAP acted against non-competitive manner with...
RNA processing is altered during malignant transformation, and expression of the polypyrimidine tract-binding protein (PTB) often increased in cancer cells. Although some data support that PTB promotes cancer, functional contribution to phenotype remains be clarified. Here we report although levels are generally cell lines from multiple origins endometrial adenocarcinoma tumors, there appears no correlation between disease severity or metastatic capacity. The three isoforms increase...