A5101765288- Nanoplatforms for cancer theranostics
- Single-cell and spatial transcriptomics
- Photodynamic Therapy Research Studies
- Electrospun Nanofibers in Biomedical Applications
- Gene expression and cancer classification
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- Gene Regulatory Network Analysis
- Ferroptosis and cancer prognosis
- Advanced Photocatalysis Techniques
- Psoriasis: Treatment and Pathogenesis
- Nanoparticle-Based Drug Delivery
- Molecular Biology Techniques and Applications
- Immune cells in cancer
- RNA modifications and cancer
- Wound Healing and Treatments
- MXene and MAX Phase Materials
- Neurogenesis and neuroplasticity mechanisms
- Tissue Engineering and Regenerative Medicine
- Advanced Nanomaterials in Catalysis
- 3D Printing in Biomedical Research
- Dermatology and Skin Diseases
- RNA Interference and Gene Delivery
- Fluoride Effects and Removal
- Medicinal Plants and Bioactive Compounds
Sun Yat-sen University
2020-2025
Fujian Agriculture and Forestry University
2023-2025
Ministry of Education
2025
Peking University
2024-2025
Chongqing University of Technology
2018-2025
Beijing University of Chemical Technology
2024
Center for Excellence in Brain Science and Intelligence Technology
2023-2024
Chinese Academy of Sciences
2023-2024
Shanghai Institutes for Biological Sciences
2024
Nanjing Medical University
2022-2024
Photo-immunotherapy is a novel therapeutic approach against malignant tumors with minimal invasiveness. Herein, targeting multifunctional black phosphorus (BP) nanoparticle, modified by PEGylated hyaluronic acid (HA), was designed for photothermal/photodynamic/photo-immunotherapy. In vitro and in vivo assays indicated that HA-BP nanoparticles possess excellent biocompatibility, stability, sufficient efficacy the combined therapy of photothermal (PTT) photodynamic (PDT) cancer therapy....
Sonodynamic therapy (SDT), which is non-invasive and controllable has the potential to treat triple-negative breast cancer (TNBC). However, hypoxia immunosuppressive tumor microenvironment (TME) often block production of reactive oxygen species induction SDT-activated immunogenic cell death, thus limiting activation adaptive immune responses. To alleviate these challenges, we proposed development a multifunctional biomimetic nanoplatform (mTSeIR), was designed with diselenide-conjugated...
The enzyme-mediated elevation of reactive oxygen species (ROS) at the tumor sites has become an emerging strategy for regulating intracellular redox status anticancer treatment. Herein, we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti3C2 nanosheets combined enzyme dynamic therapy (EDT), phototherapy and deoxygenation-activated chemotherapy. Briefly, glucose oxidase (GOX) chloroperoxidase (CPO) were chemically conjugated onto nanosheets, where drug tirapazamine (TPZ)...
Background: Research on immunogenic cell death (ICD) in lung adenocarcinoma (LUAD) has been relatively limited. This study aims to create ICD-related signatures for accurate survival prognosis prediction LUAD patients, addressing the challenge of lacking reliable early prognostic indicators this type cancer. Methods: Using single-cell RNA sequencing (scRNA-seq) analysis, ICD activity cells was calculated by AUCell algorithm, divided into high- and low-ICD groups according median values, key...
Abstract Prodrug‐based self‐assembled nanoparticles (PSNs) with tailored responses to tumor microenvironments show a significant promise for chemodynamic therapy (CDT) by generating highly toxic reactive oxygen species (ROS). However, the insufficient level of intracellular ROS and limited drug accumulation remain major challenges further clinical transformation. In this study, PSNs delivery artesunate (ARS) are demonstrated designing pH‐responsive ARS‐4‐hydroxybenzoyl hydrazide...
Abstract Tumor research is a fundamental focus of medical science, yet the intrinsic heterogeneity and complexity tumors present challenges in understanding their biological mechanisms initiation, progression, metastasis. Recent advancements single-cell transcriptomic sequencing have revolutionized way researchers explore tumor biology by providing unprecedented resolution. However, key limitation loss spatial information during preparation. Spatial transcriptomics (ST) emerges as...
The traditional evaluation of nanoparticles (NPs) is mainly based on 2D cell culture and animal models. However, these models are difficult to accurately represent human tumor microenvironment (TME) fail systematically study the complex transportation NPs, thus limiting translation nano-drug formulations clinical studies. This reports a model fabricated via 3D bioprinting with adipose decellularized extracellular matrix (ECM) enhanced hybrid bioink. Compared cultured cells, printed...
Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by loss of function mutations in maternally expressed UBE3A. No gene-specific treatment available for patients so far. Although intact and transcriptionally active, paternally inherited UBE3A silenced elongation antisense long noncoding RNA UBE3A-ATS neurons. Here, we demonstrated that targeting paternal Ube3a-ATS with high-fidelity CRISPR-Cas13 (hfCas13x.1) system could restore Ube3a expression to similar levels as maternal...
Although sonodynamic therapy (SDT) is a promising non-invasive tumor treatment strategy due to its safety, tissue penetration depth and low cost, the hypoxic microenvironment limits therapeutic effects. Herein, we have designed developed an oxygen-independent, ROS-amplifying chemo-sonodynamic antitumor based on novel pH/GSH/ROS triple-responsive PEG-PPMDT nanoparticles. The formulated artemether (ART)/Fe3O4-loaded NPs can rapidly release drug under synergistic effect of acidic endoplasmic pH...
Surgical resection remains the mainstay of melanoma treatment. However, due to difficulties in controlling tumor recurrence and wound healing simultaneously, high postoperative rates reconstruction remain most significant challenges. As a result, heterogeneous hybrid hydrogel scaffold was designed this work achieve sequential photothermal therapy chemotherapy for inhibition healing. A 3D printing platform used create SA-GG@PDA scaffold, which prepared from bioink consisting sodium alginate...
Sonodynamic therapy (SDT) benefiting from its intrinsic merits, such as noninvasiveness and deep tissue penetrability, is receiving increasing considerable attention in reactive oxygen species (ROS)-based tumor treatment. However, current sonosensitizers usually suffer low lesion accumulation, insufficient ROS generation efficiency under ultrasound, non-biodegradability, which seriously impede the therapeutic outcomes. Additionally, it difficult that SDT alone can completely eradicate tumors...
Photodynamic therapy (PDT) has emerged as an efficient approach for non-invasive cancer treatment. However, organic small-molecule photosensitizers are often associated with defects in hydrophobicity, poor photostability, and aggregation-caused quenching, which limit their application. Usually, the carrier-assisted drug delivery system is a common strategy to solve above obstacles, but additional carrier material could increase risk of potential biological toxicity. The carrier-free easy...
In this study, wheat starch (WS) was combined with different concentrations of laminarin (LM) to investigate changes in its microstructure, structure and digestibility. The application LM improve the cooking textural properties noodles also investigated. A low concentration (2%, g/100g) reduced crystallinity order degree WS, but a high had opposite effect. After addition, leached amylose content swelling power WS were significantly reduced, indicating that coats granule surface, inhibiting...
Sonodynamic therapy (SDT), which involves the activation of sonosensitizers to generate cytotoxic reactive oxygen species under ultrasound irradiation, is a promising noninvasive modality for cancer treatment. However, clinical translational application SDT impeded by lack efficient sonosensitizers, inefficient accumulation at tumor sites, and complicated immunosuppressive microenvironment. Herein, we developed facilely synthesized multifunctional porous organic polymer nanosonosensitizer...
Abstract Retinoblastoma (RB) is the most prevalent ocular tumor of childhood, and its extraocular invasion significantly increases risk metastasis. Nevertheless, a single-cell characterization RB local extension has been lacking. Here, we perform RNA sequencing on four samples (two from intraocular two patients), integrate public datasets five normal retina samples, three to characterize at level. A total 128,454 qualified cells are obtained in nine major cell types. Copy number variation...
Abstract Background Tumors exhibit metabolic heterogeneity, influencing cancer progression. However, understanding diversity in retinoblastoma (RB), the primary intraocular malignancy children, remains limited. Methods The landscape of RB was constructed based on single-cell transcriptomic sequencing from 11 and 5 retina samples. Various analyses were conducted, including assessing overall activity, correlation between hypoxia pathways. Additionally, expression pattern monocarboxylate...
High salt intake has been known to cause hypertension and other side effects. However, it is still unclear whether also affects fibrosis in the mature or developing liver. This study demonstrates that high exposure mice (4% NaCl drinking water) chick embryo (calculated final osmolality of egg was 300 mosm/L) could lead derangement hepatic cords liver using H&E, PAS, Masson, Sirius red staining. Meanwhile, Desmin immunofluorescent staining mouse livers indicated stellate cells were activated...
Background: Pyroptosis is a form of programmed cell death triggered by the rupture membranes and release inflammatory substances; it essential in occurrence development cancer. A considerable number studies have revealed that pyroptosis closely associated to biological process several cancers. However, role lung adenocarcinoma (LUAD) remains elusive. The purpose this study was explore prognostic pyroptosis-related genes (PRGs) their relationship with tumor immune microenvironment (TIME)...