A5019493678- Melanoma and MAPK Pathways
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Mechanisms of cancer metastasis
- Metal complexes synthesis and properties
- Hippo pathway signaling and YAP/TAZ
- Enzyme function and inhibition
- Gastrointestinal Tumor Research and Treatment
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- Gastric Cancer Management and Outcomes
- FOXO transcription factor regulation
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Genomics, phytochemicals, and oxidative stress
- Chemotherapy-induced organ toxicity mitigation
- Cancer-related gene regulation
- Peripheral Nerve Disorders
- Synthesis and biological activity
- Orthopedic Surgery and Rehabilitation
- Nerve Injury and Rehabilitation
- Metastasis and carcinoma case studies
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- BRCA gene mutations in cancer
National Cancer Institute
2016-2023
Center for Cancer Research
2017-2023
Cedars-Sinai Medical Center
2020
National Institutes of Health
2016-2019
Northwestern University
2019
University of Kansas
2019
Leidos (United States)
2019
Leidos Biomedical Research Inc. (United States)
2019
Tufts University
2019
University of North Carolina Health Care
2019
A compound that reduces the prevalence of perinucleolar compartment in cancer cells inhibits metastasis vivo.
Hereditary diffuse gastric cancer (HDGC) is a syndrome associated with variants in E-cadherin (CDH1), and lobular breast cancer. There considerable heterogeneity its clinical manifestations. This study aimed to determine associations between CDH1 germline variant status phenotypes of HDGC.
Chronic granulomatous disease (CGD) is a rare genetic disorder causing recurrent infections. More than one-quarter of patients develop hepatic abscesses and liver dysfunction. Recent reports suggest that disease-modifying treatment with corticosteroids effective for these abscesses. Comparison corticosteroid therapy to traditional invasive treatments has not been performed. Records 268 CGD treated at the National Institutes Health from 1980 2014 were reviewed. Patients involvement complete...
Inflammatory bowel disease (IBD), encompassing Crohn's and ulcerative colitis, is a chronic condition marked by recurring gastrointestinal inflammation. While immune, genetic, environmental factors are well-studied, the gut virome has received less attention. This editorial highlights work which investigates virome’s role in IBD its interactions with bacterial microbiome host immune system. The consists of bacteriophages, eukaryotic viruses, endogenous retroviruses. Among these, Caudovirales...
Abstract Prostate cancer (PCa) frequently develops antiapoptotic mechanisms and acquires resistance to anticancer drugs. Therefore, identifying PCa drug determinants should facilitate designing more effective chemotherapeutic regimens. Recently, we described that the PCPH protein becomes highly expressed in human prostatic intraepithelial neoplasia PCa, functional interaction between kinase Cδ (PKCδ) increases invasiveness of PCa. Here, report a different PKC isoform, PKCα, confers against...
Despite the near universal occurrence of activating codon 12 KRAS somatic variants in pancreatic cancer, there is considerable heterogeneity molecular make-up, MAPK/ERK pathway activation states, and clinical outcome this disease. We analyzed expression levels CNKSR1, a scaffold that influences activity, pancreas cancer specimens their impact on survival patients with cancer.Immunohistochemical staining for CNKSR1 was performed 120 from three independent tissue registries, phospho-ERK were...
As peripheral nerve specialists can have a wide variety of training backgrounds, few standards care exist with respect to necessary incision length, amount dissection, and operative technique for common decompressions.Approaches the following 12 surgeries were minimized using shorter incisions simple lighted retractor: zygomatico-temporal auriculotemporal, greater occipital, brachial plexus, ulnar, radial, median, lateral femoral cutaneous thigh, peroneal at groin, fibular neck calf, tibial...
Considering that several different specialties perform nerve decompressions in the upper extremity, universal technical standards do not exist. Many of these procedures are performed via incisions made unnecessarily long to achieve adequate exposure nerves and their known anatomical compression points. The purpose this article is introduce reproducible techniques reliably allow necessary while minimizing length required skin incisions.The senior author's surgical approach most common...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Abstract Combinatorial molecular therapy in pancreatic ductal adenocarcinoma (PDAC) has yielded largely disappointing results clinical testing to-date as a multitude of adaptive resistance mechanisms is making selection patients via markers that capture essential, intersecting signaling routes challenging. Here, we report the scaffolding protein connector enhancer kinase suppressor Ras 1 (CNKSR1) mediator to MAPK (MEK) inhibition. MEK inhibition CNKSR1high cancer cells induces translocation...
With advances in treatment of cancer, patients who survive their first malignancy are at risk developing additional malignancies. Data on the risks secondary malignancies after some more common cancers lacking.Our prospectively maintained database was queried from 1996 to 2016 identify with breast colorectal melanoma, sarcoma, gastric, and pancreatic adenocarcinoma developed Predisposing clinical factors were included our analysis.We identified 756 diagnosed a solid second malignancy, which...
Supplementary Materials and Figures 1-3 from PCPH/ENTPD5 Expression Confers to Prostate Cancer Cells Resistance against Cisplatin-Induced Apoptosis through Protein Kinase Cα–Mediated Bcl-2 Stabilization
Supplementary Materials and Figures 1-3 from PCPH/ENTPD5 Expression Confers to Prostate Cancer Cells Resistance against Cisplatin-Induced Apoptosis through Protein Kinase Cα–Mediated Bcl-2 Stabilization
<p>Lists of cell lines, antibodies, RNAi kinome screen; and matrix drug combination.</p>
<p>Selumetinib fails to recruit CNKSR1 and p-AKT the plasma membrane in low cell lines; Proximal ligation of lines treated with vehicle vs selumetinib;CNKSR1 PLA signal after treatment selumetinib is dependent on presence both primary antibodies; Silencing CNKSR1high abrogates signal; Immunofluorescence staining PIP3 YAPC selumetinib.</p>
<p>Resistance to MEK inhibition in YAPC cells is not due reactivation of phospho-Extracellular-signal-regulated-kinases (ERK) levels.</p>
<p>Secondary validation of candidate genes.</p>
<p>Schematic layout of the selumetinib versus 26 compounds targeting effector signaling CNKSR1 screen; and Dose response MK-2206 rapamycin in pancreas cancer cell lines.</p>