A5100386482- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Autoimmune and Inflammatory Disorders
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Frailty in Older Adults
- Adipokines, Inflammation, and Metabolic Diseases
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Gastroesophageal reflux and treatments
- Metabolomics and Mass Spectrometry Studies
- Syphilis Diagnosis and Treatment
- Gut microbiota and health
- Cancer-related gene regulation
- Fungal Infections and Studies
- IgG4-Related and Inflammatory Diseases
- Body Composition Measurement Techniques
- Acute Ischemic Stroke Management
- Antifungal resistance and susceptibility
- Tryptophan and brain disorders
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Diet, Metabolism, and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
Shanghai Jiao Tong University
2014-2025
Chongqing Jiulongpo People's Hospital
2024
Shanghai University of Medicine and Health Sciences
2022-2024
Shandong First Medical University
2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2021-2024
Xuzhou Medical College
2024
Second People’s Hospital of Huai’an
2024
Shandong Provincial Hospital
2024
The Fourth People's Hospital
2022-2023
Renji Hospital
2008-2023
As a newly identified and characterized gene, p42.3 is associated with cell proliferation tumorigenicity. The expression of upregulated in human gastric cancer (GC), but its underlying mechanisms action are not well understood. MicroRNAs (miRNAs) known to play vital regulatory roles many cellular processes. Here we utilized bioinformatics experimental approaches investigate the relationship between miRNAs gene. We showed that miR-29a could repress at both mRNA protein levels via directly...
Abstract The aim of the present study is to investigate relationship between sarcopenia and cardiovascular risk factors (CVRF) in Chinese elderly. A total 1611 elderly individuals aged ≥60 years were enrolled this study. well-established CVRF diabetes, hypertensions, dyslipidemia assessed. Sarcopenia was defined according recommended algorithm Asian Working Group for (AWGS). Multiple logistic regression analyses linear regressions used evaluate components number patients with sarcopenia....
This study explored potential biomarkers associated with Lauren classification of gastric cancer. We screened microarray datasets on cancer information in GEO database, and compared differentially expressing genes between intestinal-type or diffuse-type Four sets data (GSE2669, GSE2680, GDS3438 GDS4007) were enrolled into analysis. By differential gene analysis, UBE2C, CDH1, CENPF, ERO1L, SCD, SOX9, CKS1B, SPP1, MMP11 ANLN identified as the top related to cancer, MGP, FXYD1, FAT4, SIPA1L2,...
Objective. Functional dyspepsia is a common gastrointestinal disorder. The pathogenesis of functional remains unclear. may begin after bout gastroenteritis (post-infectious dyspepsia) or de novo (nonspecific dyspepsia). aim this study was to investigate the prevalence and probable mechanisms post-infectious dyspepsia. Material methods. patients with history unsanitary food intake acute 6-12 months ago were enrolled. 13C-UBT confirmed absence H. pylori infection. Controls consisted healthy...
Objective Talaromycosis is a serious regional disease endemic in Southeast Asia. In China, Talaromyces marneffei (T. marneffei) infections mainly concentrated the southern region, especially Guangxi, and cause considerable in-hospital mortality HIV-infected individuals. Currently, factors that influence death of HIV/AIDS patients with T . infection are not completely clear. Existing machine learning techniques can be used to develop predictive model identify relevant prognostic predict...
Abstract Background The prevalence of H. pylori is as high 60–70% in Chinese population. Although duodenal ulcer and gastric cancer are both caused by , they at opposite ends the spectrum such considered mutually exclusive. Duodenal promoting ( dupA ) gene was reported to be associated with development. aim this study determine Helicobacter patients various gastroduodenal diseases explore association between other virulence factors. Methods were isolated from biopsies chronic gastritis,...
The histone lysine methyltransferase NSD2 is overexpressed, translocated, or mutated in multiple types of cancers and has emerged as an attractive therapeutic target. However, the development small-molecule inhibitors still its infancy, selective efficacious are highly desirable. Here, view structural novelty reported inhibitor DA3003-1, we conducted a comprehensive optimization based on quinoline-5,8-dione scaffold. Compound 15a was identified possessing both high inhibitory activity potent...
Abstract Colorectal adenoma (CRA) is the precursor lesion of colorectal cancer (CRC). Several agents have been shown to be effective in chemoprevention CRA recurrence, but there has little research on its primary prevention. Participants older than 50 years with no adenomas were recruited for our study and randomized receive either 1 mg/day folic acid supplement or treatment without acid. After 3 follow-up, plasma folate colonoscopy evaluated. Seven hundred ninety-one participants (91.98%)...
Abstract We sought to identify common key regulators and build a gene-metabolite network in different nonalcoholic fatty liver disease (NAFLD) phenotypes. used high-fat diet (HFD), methionine-choline-deficient (MCDD) streptozocin (STZ) establish (NAFL), steatohepatitis (NASH) NAFL+type 2 diabetes mellitus (T2DM) rat models, respectively. Transcriptomics metabolomics analyses were performed livers serum. A functional network-based regulation model was constructed using Cytoscape with...
We describe the opportunistic infections (OIs) of HIV/AIDS to understand spectrum, mortality, and frequency multiple coinfected OIs among patients in southern China, where are severe. carried out a retrospective cohort study hospitalized HIV-infected individuals at Fourth People's Hospital Nanning, Guangxi, from Jan. 2011 May. 2019. The chi-square test was used analyze cross-infection; Kaplan‒Meier analysis compare mortality. A total 12,612 were admitted this study. Among them, 8982 (71.2%)...
Non-alcoholic fatty liver (NAFL) has the potential to progress non-alcoholic steatohepatitis (NASH) or promote type 2 diabetes mellitus (T2DM). However, NASH and T2DM do not always develop coordinately. Additionally, there are no definite noninvasive methods for diagnosis currently. We established rat models of NAFL, NASH, NAFL + recapitulate different phenotypes associated with disease (NAFLD) its progression. Histologic features livers were scored according criteria by Nonalcoholic...
Objective Up to now, non-invasive diagnosis of laterally spreading tumor (LST) and prediction adenoma recurrence after endoscopic resection LSTs is inevitable. This study aimed identify a microbial signature with clinical significance diagnosing predicting colectomy. Methods We performed 16S rRNA sequencing in 24 mucosal samples, including 5 healthy controls (HC), 8 colorectal (CRA) patients, 11 LST patients. The differentiating microbiota fecal samples was quantified by qPCR 475 cases 113...
Reduced muscle strength, as measured by handgrip strength (HS), has been associated with an increased risk of cardiovascular disease (CVD). The aim this study was to examine the association between different HS indexes and CVD factors in elderly Chinese individuals. We also determine optimal cutoffs for predicting factors. Data were obtained from 603 men 789 women aged ≥60 years (average age 66.8 ± 6.4 y). These participants recruited suburb area Tianjin, China. An individual considered a...
Surfactin, produced by
BACKGROUND: Regardless of surgical technique, patients who have undergone cholecystectomy appear to be predisposed the development bile reflux gastritis. OBJECTIVE: To assess efficacy rabeprazole and hydrotalcite in with gastritis after cholecystectomy. METHODS: Postcholecystectomy confirmed by endoscopy 24 h gastric bilirubin monitoring were randomly assigned one four eight-week treatments: observation (group A), alone B), C) combination D). Endoscopy repeated all treatment. Dyspeptic...
microRNAs (miRNA) are promising predictors in colorectal cancer (CRC). We investigated whether miRNAs could predict adenoma recurrence patients with advanced (ACRA) after polypectomy. miRNA expression profiling was performed by microarray to identify recurrence-related miRNAs. Candidate extracted from formalin-fixed paraffin-embedded blocks of ACRA were measured using real-time PCR. Logistic regression analysis conducted investigate validated profiles independent other known risk factors....
Abstract Multidimensional health function impairments are common in older patients with chronic kidney disease (CKD). The purpose of this study was to explore whether the risk or severity geriatric syndrome increased a decline renal function. This survey conducted for CKD aged ≥ 60 years and hospitalized at West China Hospital Sichuan University (Center Gerontology Geriatrics, Nephrology, Endocrinology) Chengdu Kangfu Kidney Disease from September 01, 2013 June 30, 2014. Patients underwent...
Objective. Nonalcoholic fatty liver disease (NAFLD) is a mitochondrial associated with the metabolic syndrome, but few data are available on dysfunction of NAFLD after development type 2 diabetes mellitus (T2DM). We aimed to identify changes function in rat livers when T2DM develops NAFLD. Material and methods. Rat models nonalcoholic (NAFL) were established using high-fat diet streptozocin. Mitochondria isolated from livers. The levels reactive oxygen species (ROS) mRNA protein complex IV...
The Alberta Stroke Program Early CT Score (ASPECTS) and hyperdense vessel sign (HDVS) on baseline non-contrast (NCCT) may benefit prognosis of acute ischemic stroke (AIS). We aimed to investigate the agreement ASPECTS between automated manual interpretations, further understand roles NCCT Perfusion (CTP) in prognosis.From January 2019 May 2020, thrombolysis-treated AIS patients undergoing imaging before treatment were retrospectively reviewed. A radiologist, a senior neuroradiologist...
To validate transient elastography (Fibroscan) in assessment of hepatic fibrosis autoimmune hepatitis (AIH).Liver stiffness was assessed using Fibroscan totally 30 patients with AIH. We compared the results Scheuer stage liver biopsy each patient.4 were shown as S0, 6 S1, 5 S2, 11 S3 and 4 S4. Failure measurement occurred 1 case (3.3%) because her increased body mass index (BMI). The significantly correlated (r = 0.801, P less than 0.001). stiffnesses between mild moderate (S0-2) advanced...