A5039286429- Congenital heart defects research
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Drug-Induced Hepatotoxicity and Protection
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Cancer-related Molecular Pathways
- Congenital Heart Disease Studies
- Liver physiology and pathology
- Drug Transport and Resistance Mechanisms
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- Ocular Oncology and Treatments
- Cardiac electrophysiology and arrhythmias
- Signaling Pathways in Disease
- Pluripotent Stem Cells Research
- Bone Metabolism and Diseases
- Ginseng Biological Effects and Applications
- Health, Environment, Cognitive Aging
- Immune Response and Inflammation
- Gut microbiota and health
- Heat shock proteins research
- RNA Interference and Gene Delivery
- Cancer Cells and Metastasis
Fudan University
2015-2025
Shanghai Medical College of Fudan University
2025
State Key Laboratory of Medical Neurobiology
2020-2023
Shenzhen Polytechnic
2023
Hong Kong Polytechnic University
2023
National Institute of Allergy and Infectious Diseases
2023
National Institutes of Health
2023
Soochow University
2020-2022
Jiangnan University
2022
Beihang University
2020-2021
Abstract Cholesterol sulfate, produced by hydroxysteroid sulfotransferase 2B1 (SULT2B1), is highly abundant in the intestine. Herein, we study functional role and underlying intestinal epithelial repair mechanisms of cholesterol sulfate ulcerative colitis. The levels as well expression Sult2b1 genes involved biosynthesis, are significantly higher inflamed tissues from patients with colitis than mucosa healthy controls. gut circulation mainly catalyzed SULT2B1. Specific deletion gene cells...
IL-4 induces Akt activation in macrophages, required for full M2 (alternative) polarization. We examined the roles of Gαi1 and Gαi3 polarization using multiple genetic methods. Methods Results: In MEFs primary murine BMDMs, Gαi1/3 shRNA, knockout or dominant negative mutations attenuated IL-4-induced IL4Rα endocytosis, Gab1 recruitment as well activation, leaving STAT6 signaling unaffected. Following stimulation, proteins associated with intracellular domain IL-4Rα APPL1 adaptor, to mediate...
IGF2BP1 overexpression promotes hepatocellular carcinoma (HCC) progression. Long non-coding RNA LIN28B-AS1 directly binds to IGF2BP1. In the present study, and expression their potential functions in HCC cells were tested. Genetic strategies applied interfere expression, cell survival, proliferation apoptosis analyzed. We show that is expressed established/primary human tissues. RNA-immunoprecipitation (RIP) pull-down results confirmed associated with protein cells. silencing (by targeted...
Pancreatitis is the leading cause of hospitalization in gastroenterology, and no medications are available for treating this disease current clinical practice. FXR plays an anti-inflammatory role diverse inflammatory diseases, while its function pancreatitis remains unknown. In study, we initially observed a marked increase nuclear pancreatic tissues human patients with pancreatitis. Deleting acinar cells (FXR Δ / ) led to more severe mouse models caerulein-induced acute chronic...
Tumor cells metastasize from a primary lesion to distant organs mainly through hematogenous dissemination, in which tumor cell re-adhesion the endothelium is essential before extravasating into target site. We thus hypothesize that with ability adhere of specific organ exhibit enhanced metastatic tropism this organ. This study tested hypothesis and developed an vitro model mimic adhesion between brain under fluid shear stress, selected subpopulation strength. The up-regulated genes related...
It is urgent to identify and validate biomarkers for early diagnosis efficient treatment of nasopharyngeal carcinoma (NPC). Recent studies have proposed p38 gamma (p38γ) as a cyclin-dependent kinase (CDK)-like that phosphorylates retinoblastoma (Rb) promote cyclins expression tumorigenesis. Here the Gene Expression Profiling Interactive Analysis (GEPIA) database results from local NPC tissues demonstrate p38γ significantly upregulated in tissues, correlating with poor overall survival....
Carbon tetrachloride (CCl4), Concanavalin A (ConA), bile duct ligation (BDL), and liver resection (LR) are four types of commonly used mouse models acute injury. However, these belong to different cell damage while their application situations often confounded. In addition, the systematic changes multiple extra-liver organs after injury crosstalk between remain unclear. Here, we aim map morphological, metabolomic transcriptomic systematically search for potential organs. Significant...
Hepatocyte growth factor (HGF) is a multifunctional that promotes various biological processes. However, the effect of HGF on bone metabolism in rheumatoid arthritis (RA) remains unknown. Here, we investigated role regulating osteoclastogenesis and resorption RA.The expression RA patients collagen-induced (CIA) mice was examined. The analysed by assays. inhibition evaluated CIA model. mechanism explored series vitro studies.HGF overexpressed RA. stimulated vitro. SU11274, selective small...
Abstract Mechanical stimulation is an important factor regulating mesenchymal stem cell (MSC) functions such as proliferation. The Ca 2+ ‐activated K + channel, 3.1, critically engaged in MSC proliferation but its role mechanical regulation of remains unknown. Here, we examined the 3.1 channel expression and rat bone marrow‐derived (BMSC) response to stretch. Application stretch stimulated BMSC via promoting cycle progression. Such up‐regulated pharmacological or genetic inhibition strongly...
Adult mammalian heart repair after myocardial damage is highly inefficient due to the post-mitotic nature of cardiomyocytes. Interestingly, in traditional Chinese medicine (TCM), there are reported effective treatments infarction (MI) and failure adult humans by oral intake a TCM concoction named Gu Ben Pei Yuan San (GBPYS), which composed Panax ginseng, velvet antler, Gekko gecko Linnaeus tail, human placenta, Trogopterus dung, notoginseng, amber. We fed mice with GBPYS damages through...
Radix Paeoniae Alba (RPA) and other natural medicines have remarkable curative effects are widely used in traditional Chinese Medicine (TCM). However, due to their multi-component multi-target characteristics, it is difficult study the detailed pharmacological mechanisms for those vivo. Therefore, real on organisms still uncertain.RPA was selected as research object, present designed complex of RPA vivo by integrating interpreting transcriptomic based RNA-seq metabolomic NMR spectrum after...
Abstract Vascular stiffening, an early and common characteristic of cardiovascular diseases (CVDs), stimulates vascular smooth muscle cell (VSMC) proliferation which reciprocally accelerates the progression CVDs. However, mechanisms by extracellular matrix stiffness accompanying stiffening regulates VSMC remain largely unknown. In present study, we examined role intermediate‐conductance Ca 2+ ‐activated K + (IK ) channel in regulation growing A7r5 cells on soft stiff polydimethylsiloxane...
Oxygen and glucose deprivation (OGD)-re-oxygenation (OGDR) stimulation to the human endometrial cells mimics ischemia-reperfusion injury.Cyclophilin D (CypD)-dependent programmed necrosis pathway mediates OGDRinduced cytotoxicity cells.We here identified a novel CypD-targeting miRNA, microRNA-1203 (miR-1203).In T-HESC primary cells, ectopic overexpression of miR-1203, using lentiviral construct, potently downregulated CypD 3'-untranslated region (3'-UTR) activity its expression.Both were...
Abstract Myocardial regeneration has been considered a promising option for the treatment of adult myocardial injuries. Previously, chick early amniotic fluid (ceAF) preparation was shown to contain growth-related factors that promoted embryonic growth and cellular proliferation, though nature components within ceAF were not fully defined. Here we tested whether this is similarly effective in promotion regeneration, which could provide an alternative therapeutic intervening injury. In study,...
ABSTRACT Ferroptosis is a type of cell death that strongly associated with the cellular redox state. Glutathione key to buffering lipid peroxidation in ferroptosis and can also modify proteins by S-glutathionylation under oxidative stress. Here, we showed strong associations among glutathione pools, protein S-glutathionylation, susceptibility existed broadly induced erastin or acetaminophen. Deficiency CHAC1, glutathione-degrading enzyme, led decreased pools reduced improved liver function...