A5030904534- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- Cancer Treatment and Pharmacology
- Traditional Chinese Medicine Analysis
- Graphene and Nanomaterials Applications
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Drug Transport and Resistance Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Venous Thromboembolism Diagnosis and Management
- Advanced Nanomaterials in Catalysis
- Berberine and alkaloids research
- Radiopharmaceutical Chemistry and Applications
- HER2/EGFR in Cancer Research
- Advancements in Transdermal Drug Delivery
- Phytochemistry and biological activity of medicinal plants
- Heparin-Induced Thrombocytopenia and Thrombosis
- Acute Myeloid Leukemia Research
- Phytochemistry and Biological Activities
- Histone Deacetylase Inhibitors Research
- Proteoglycans and glycosaminoglycans research
Heilongjiang University of Chinese Medicine
2015-2025
Central South University
2021-2022
Xiangya Hospital Central South University
2021-2022
National Clinical Research Center for Digestive Diseases
2021-2022
Chongqing University
2022
PharmacoGenetics (China)
2021
Heilongjiang University
2010-2016
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2011
Jilin University of Finance and Economics
2009
Peking University
2002-2008
Current therapy of malignant glioma in clinic is unsatisfactory with poor patient compliance due to low therapeutic efficiency and strong systemic side effects. Herein, we combined chemo-photothermal targeted within one novel multifunctional drug delivery system. A targeting peptide (IP)-modified mesoporous silica-coated graphene nanosheet (GSPI) was successfully synthesized characterized, first introduced the field. doxorubicin (DOX)-loaded GSPI-based system (GSPID) showed heat-stimulative,...
Tumor site-directed multifunctional therapeutic platforms such as photothermochemotherapy that respond to tumor-focused physical and biological stimuli are highly demanded for effective cancer therapy. Herein, targeting peptide-conjugated core–shell graphitic carbon@silica nanospheres with dual-ordered mesopores (MMPS) were successfully fabricated developed antitumoral doxorubicin (DOX) delivery system (MMPSD) synergistic targeted photothermal chemotherapy of breast cancer. The hydrophilic...
To investigate the possibility of enhancing effect deformable vesicles on buccal delivery insulin, two kinds with and without presence sodium deoxycholate (deformable conventional vesicles) were prepared by reverse phase evaporation methods. The liposomal entrapment efficiency was determined column chromatography. particle size morphology also evaluated. hypoglycemic effects, insulin concentrations, residual amounts deposited in membrane after administration to rabbits investigated. Compared...
Background/Objectives: Platycodon grandiflorus (PG) has been widely researched as a conductant drug for the treatment of lung diseases by ancient and modern traditional Chinese medicine (TCM) practitioners. Inspired mechanism our previous finding about fructans fructooligosaccharides from (FFPG), we developed nano delivery system (NDDS) targeting cancer. The aim was to improve efficiency liposomal Paclitaxel (PTX) enhance anti-tumor efficacy. Methods: FFPG-Lip-PTX NDDS prepared electrostatic...
1.Atorvastatin Calcium (AC) is the first line lipid-lowering drug in clinical. Nowadays, combination of AC and BBR often used to treat hyperlipidemia In order determine mechanism, we investigate regulatory atorvastatin combined with berberine on PI3K/Akt/FoxO1 signaling pathway rats hyperlipidemia.2.The rat model was constructed. Meanwhile, liver protective effects were determined by oil red O H&E method. The expression PI3K, Akt FoxO1 examined IHC, WB RT-pCR. level CK LDH serum ELISA.3.The...
The selectivity of chemotherapeutic agents for liver cancer is poor. When they kill tumour cells, produce serious adverse reactions in the whole body and multidrug resistance (MDR) also a major hurdle chemotherapy. Combination therapy useful method overcoming MDR reducing toxic side effects. In this study, we developed long-circulating codelivery system, which doxorubicin (DOX) schizandrin A (SchA) are combined against MCF-7/ADR cells. DOX-SchA liposome (DOX-SchA-Lip) was prepared using...
A general strategy is developed for dual-triggered chemo-photothermal tumor therapy based on template semi-graphitized mesoporous silica nanoparticles (TsGMSN). The endues classic MSN with new charming properties, while easily escaping from toxicity of the surfactant. doxorubicin-loaded system (TsGMSND) exhibits synergistic heat-stimulative, pH-responsive, and sustained release, effective combined therapy.
The most effective method to reduce chronic hepatitis B virus infection is the universal implementation of vaccination. commercial aluminum-based vaccines need multiple-injection protocols for complete protection resulting in poor compliance developing countries. It necessary develop single-shot vaccine formulations. In this study, novel antigen-loaded DDAB/PLA (didodecyldimethylammonium bromide/poly(lactic acid)) nanoparticles (NPs)-alginate composite microcapsules were developed as a...
Effective interaction between mucoadhesive drug delivery systems and mucin is the basis of effective local placement drugs to play its therapeutic role after mucosal administration including vaginal use, which especially requires prolonged presence for treatment gynecological infectious diseases. Our previous report on phenylboronic acid-rich nanoparticles (PBNPs) demonstrated their strong with mucin-sensitive release profiles model protein therapeutics interferon (IFN) in vitro, but poor...
Background: Recently, one of the specific BH3-mimetics, Venetoclax has been approved by FDA providing new options for newly diagnosed AML patient especially who are unfitted to receive conventional chemotherapy. Though clinical success venetoclax achieved in outcomes such as complete remission (CR) and overall survival. Acquired resistance ABT-199 which is induced regulation apoptosis pathway still an important problem. To this end, attempt combine drugs can reverse compensatory urgent....
Icaritin (ICT) and hydrous icaritin (HICT) are two similar flavonoids compounds isolated from Epimedium Genus. This is the first comparative study on their in vitro vivo antitumor effects. Nanorods (NRs) were prepared for ICT HICT by anti-solvent precipitation method using D-alpha tocopherol acid polyethylene glycol succinate (TPGS) as a stabilizer. The ICT-NRs HICT-NRs had diameter (155.5 nm 201.7 nm), high drug loading content (43.30 ± 0.22% 41.08 0.19%), excellent stability sustaining...
Atorvastatin, an effective lipid-lowering drug, could reduce the risks of morbidity and mortality cardiovascular diseases. Patients with diseases often use atorvastatin along berberine. Atorvastatin is substrate CYP3A4 P-gp. However, berberine inhibitor. The combination might lead to DDIs. aim this study was assess effect on pharmacokinetics pharmacodynamics in rats.Plasma concentrations or without were determined by HPLC. Pharmacokinetics parameters calculated used evaluate interactions....