A5102933915- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Solar-Powered Water Purification Methods
- Eicosanoids and Hypertension Pharmacology
- Carbon and Quantum Dots Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aquatic Ecosystems and Phytoplankton Dynamics
- Mitochondrial Function and Pathology
- Solar Thermal and Photovoltaic Systems
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Optical Systems and Laser Technology
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Neonatal Respiratory Health Research
- Lung Cancer Treatments and Mutations
- Advanced Nanomaterials in Catalysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Photocatalysis Techniques
- Cell death mechanisms and regulation
- Electrocatalysts for Energy Conversion
- Crystallography and molecular interactions
- Sepsis Diagnosis and Treatment
Central South University
2019-2024
Southwest Minzu University
2024
Yulin Normal University
2024
Anhui Normal University
2021-2023
China West Normal University
2020-2022
Chongqing Jiaotong University
2021-2022
Chemical Synthesis Lab
2021
Fudan University
2017-2021
National Yang Ming Chiao Tung University
2021
Asia University
2021
Abstract Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19 (refs. 1–3 ), but they still exhibit critical limitations caused by mRNA instability and degradation, which major obstacles for storage, distribution efficacy vaccine products 4 . Increasing secondary structure lengthens half-life, which, together with optimal codons, improves protein expression 5 Therefore, a principled design algorithm must optimize both structural stability codon usage. However, owing...
Incorporating carbon nanodots (CDs) into mesoporous silica framework for extensive biomedicine, especially the desirable cancer immunotherapy, is considered to be an unexplored challenge. Herein, a hydrogen bond/electrostatic-assisted co-assembly strategy was smartly exploited uniformly incorporate polymer-coated CDs ordered of nanoparticles (CD@MSNs). The obtained CD@MSN not only biodegradable via framework-incorporated CD-induced swelling but also capable gathering dispersive with enhanced...
Abstract Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation mitochondrial citrate (citrate mt ) lipopolysaccharide (LPS)-treated AECs because downregulation Idh3α and carrier (CIC, also known as Slc25a1). shRNA- or inhibitor–mediated inhibition Slc25a1 induced necroptosis vitro. Mice with AEC-specific deficiency exhibited exacerbated AEC...
Imaging-guided site-specific photothermal therapy (PTT) of glioma and other tumors in central nervous system presents a great challenge for the current nanomaterial design. Herein, an situ solid-state transformation method was developed preparation multicolor highly crystalline carbon nanodots (HCCDs). The synthesis yields 6-8 nm-sized HCCDs containing nanocore hydrophilic surface, which therefore simultaneously provide strong photoacoustic performances as well tunable fluorescence emission....
Solar water evaporation is an economical and sustainable solution to produce clean via the heat localization of photothermal conversion. However, it remains a great challenge for full optimization thermal management improve solar-to-vapor efficiency. Herein, we report broadband semiconductor foam architecture that simply created by in situ sulfuration nickel (NF) vertically aligned growth Ni3S2 nanosheet arrays (Ni3S2/NF) demonstrate synergetic during solar simultaneous electricity...
Pulmonary fibrosis (PF) is a senescence-associated disease with poor prognosis. Currently, there no effective therapeutic strategy for preventing and treating the process. Mounting evidence suggests that arachidonic acid (ARA) metabolites are involved in pathogenesis of various fibrosis. However, relationship between metabolism ARA PF still elusive. In this study, we observed disorder cyclooxygenase-2/cytochrome P450 (COX-2/CYP) lungs mice induced by bleomycin (BLM). Therefore, aimed to...
The thermal field effect effectively boosts water splitting electrocatalysis by lowering activation energy barriers and accelerating sluggish kinetics.
// Yongqiang Wang 1, 2, * , Yuan Yu 3, Rui Ye Duo Zhang Qiaoling Li 3 Dan An Lu Fang 4 Youcheng Lin 5 Yong Hou Abai Xu Fu 6 Wei Xin Chen 1 Mingwei Meng Huiling Jiang 7 Chuanxia 8 Pei Dong Chong 9 Jun 10 Guosheng Yang Chunxiao Liu Zhiming Cai 11 Fangjian Zhou Song Wu Department of Urology, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Medicine, State Key Laboratory Oncology in South China, Guangzhou, 510060, China 2 The Affiliated Luohu Hospital Shenzhen...
Hydrogels are important in biological and medical applications, such as drug delivery tissue engineering. DNA hydrogels have attracted significant attention due to the programmability biocompatibility of material. We developed a series low-cost one-strand self-assembled from single-stranded monomers containing multiple palindromic domains. This new hydrogel design is simple programmable. Thermal stability, mechanical properties, loading capacity these can be readily regulated by simply adjusting
Arachidonic acid can be metabolized to prostaglandins and epoxyeicosatrienoic acids (EETs) by cyclooxygenase-2 (COX-2) cytochrome P450 (CYP), respectively. While protective EETs are degraded soluble epoxide hydrolase (sEH) very fast. We have reported that dual inhibition of COX-2 sEH with specific inhibitor PTUPB shows anti-pulmonary fibrosis renal protection. However, the effect on cecal ligation puncture (CLP)-induced sepsis remains unclear. The current study aimed investigate effects...
The effective treatment of glioma is largely hindered by the poor transfer drug delivery systems across blood-brain barrier (BBB) and difficulty in distinguishing healthy tumorous cells. In this work, for first time, an interleukin-6 receptor binding I6P7 peptide was exploited as a cascade-targeting ligand combination with succinoyl tetraethylene pentamine (Stp)-histidine oligomer-based nonviral gene system (I6P7-Stp-His/DNA). provides multiple functions, including potential represented...
Accumulating evidence indicates that angiotensin (1-7) [Ang-(1-7)] protects against idiopathic pulmonary fibrosis (IPF) in animal experiments. However, whether Ang-(1-7) effectively inhibits epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1) remains unclear. The aim of this study is to examine the eff ;ects on TGF-β1-induced EMT human alveolar epithelial cells. We found angiotensin-converting enzyme 2 (ACE2) /Ang-(1-7)/MasR were decreased lungs mice with...
Despite the importance of skin mucosal barrier and commensal microbiota for health amphibians, potential environmental contaminants to disrupt have rarely been studied in toxicology. In this study, tadpoles (Lithobates catesbeianus) were exposed 0, 0.5, 2 μg/L microcystin-leucine arginine (MC-LR) 30 days explore impacts environmentally realistic MC-LR concentrations on physical barrier, immune microbiota, resistance pathogenic bacterial invasion. exposure significantly reduced collagen...
Abstract Necroptosis, a recently described form of programmed cell death, is the main way alveolar epithelial cells (AECs) death in acute lung injury (ALI). While mechanism how to trigger necroptosis AECs during ALI has been rarely evaluated. Long optic atrophy protein 1 (L‐OPA1) crucial mitochondrial inner membrane fusion protein, and its deficiency impairs function. This study aimed investigate role L‐OPA1 deficiency‐mediated dysfunction necroptosis. We comprehensively investigated...