A5101647725- Forest ecology and management
- Soil Carbon and Nitrogen Dynamics
- Forest, Soil, and Plant Ecology in China
- Forest Ecology and Biodiversity Studies
- Plant Ecology and Soil Science
- Plant Water Relations and Carbon Dynamics
- Parkinson's Disease Mechanisms and Treatments
- Seaweed-derived Bioactive Compounds
- Nutrition and Health in Aging
- Fire effects on ecosystems
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Environmental and Agricultural Sciences
- Ecology and Vegetation Dynamics Studies
- Mycorrhizal Fungi and Plant Interactions
- Forest Management and Policy
- Frailty in Older Adults
- Peatlands and Wetlands Ecology
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Sperm and Testicular Function
- Cerebral Palsy and Movement Disorders
- Glycosylation and Glycoproteins Research
- Reproductive Biology and Fertility
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
Shandong University of Traditional Chinese Medicine
2017-2025
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2025
Hubei University of Medicine
2025
Qingdao University
2013-2024
Academy of Medical Sciences
2024
Peking Union Medical College Hospital
2024
Northwest A&F University
2006-2023
Capital Medical University
1999-2022
Renji Hospital
2017-2021
Non-coding RNAs (ncRNAs) are considered major players in physiological and pathological processes based on their versatile regulatory roles different diseases including cardiovascular disease. Circular (circRNAs), a newly discovered class of RNAs, constitute substantial fraction the mammalian transcriptome abundantly expressed system. However, functions these circRNAs ischemic cardiac disease remain largely unknown. Here, we investigated role circRNA transcribed from sodium/calcium exchanger...
Background Fucoidan is a sulfated polysaccharide derived from brown algae that has been reported to perform multiple biological activities, including antitumor activity. In this study, we examined the influence of crude fucoidan on mouse breast cancer in vitro and vivo. Materials Methods vitro, fluorescent staining, flow cytometry Western blot were performed analyze apoptosis vascular endothelial growth factor (VEGF) expression 4T1 cells. vivo, therapy experiments conducted Babl/c mice...
Aims: Cardiomyocyte death critically contributes to the pathogenesis of cardiac disorders, such as myocardial infarction, heart failure, and ischemia/reperfusion (I/R) injury. As one main forms cell death, necrosis plays a critical role in diseases. Multiple signaling pathways have been demonstrated, which receptors, receptor-interacting serine/threonine-protein 1 3 kinases, cyclophilin-D (CypD) deeply implicated. However, fundamental mechanism underlying necroptosis, especially...
Abstract Background Persistent inflammation dysregulation and cognitive decline have been associated with several trauma- stress-related disorders such as posttraumatic stress disorder (PTSD) anxiety disorder. Despite the abundant discoveries of neuroinflammation in disorders, underlying mechanisms still remain unclear. Method Wild-type Nlrp3 −/− mice were exposed to electric foot shocks contextual fear memory paradigm. Three hours after shocks, activation NLRP3 inflammasome was investigated...
Abstract The aim of the present study is to investigate relationship between sarcopenia and cardiovascular risk factors (CVRF) in Chinese elderly. A total 1611 elderly individuals aged ≥60 years were enrolled this study. well-established CVRF diabetes, hypertensions, dyslipidemia assessed. Sarcopenia was defined according recommended algorithm Asian Working Group for (AWGS). Multiple logistic regression analyses linear regressions used evaluate components number patients with sarcopenia....
Fucoidan is a sulfated polysaccharide derived from brown algae and known to possess anticancer properties. However, the relationship between fucoidan β-catenin, one of key components Wnt signaling pathway, in mouse breast cancer remains poorly characterized. In this study, cells (4T1) were exposed investigate Wnt/β-catenin pathway vivo vitro. We found that significantly inhibited cell growth, increased death, induced G1 cycle arrest 4T1 cells. also reduced β-catenin expression T...
The recent 2014–2016 West African Ebola virus epidemic underscores the need for development of novel anti-Ebola therapeutics, due to high mortality rates infections and lack FDA-approved vaccine or therapy that is available prevention treatment. Traditional Chinese medicines (TCMs) represent a huge reservoir bioactive chemicals many TCMs have been shown antiviral activities. 373 extracts from 128 were evaluated using throughput assay screen inhibitors cell entry. Extract Rhodiola rosea...
Soil labile organic carbon (LOC) responds rapidly to environmental changes and plays an important role in cycle. In this study, the seasonal fluctuations LOC, activities of carbon-cycle related enzymes, bacterial fungal communities were analyzed for soils collected from two forests, namely Betula albosinensis (Ba) Picea asperata Mast. (Pa), Qinling Mountains China. Results revealed that average contents microbial biomass (MBC), easily oxidized (EOC), dissolved (DOC) Pa forest soil 13.5%,...
Pro-inflammatory cytokines induced by inflammation and iron accumulation in the substantia nigra (SN) have been implicated pathogenesis of Parkinson's disease (PD). In present study, we aimed to investigate relationship between a lipopolysaccharide (LPS)-induced Parkinsonian rat model. The activation glial cells elevated levels pro-inflammatory were observed SN LPS models, accompanied deposits same region. Moreover, ferroportin (Fpn), only channel for export, was down-regulated. SH-SY5Y...
The therapeutic management of obesity is challenging, hence further elucidating the underlying mechanisms development and identifying new diagnostic biomarkers targets are urgent necessary. Here, we performed differential gene expression analysis weighted co-expression network (WGCNA) to identify significant genes specific modules related BMI based on profile data 7 discordant monozygotic twins. In analysis, it appeared that 32 differentially expressed (DEGs) were with a trend up-regulation...
Abstract Background This study was to investigate the effect and its possible mechanism of fucoidan on development spontaneous autoimmune diabetes in non-obese diabetic (NOD) mice. Methods 7-week-old NOD mice were randomly divided into three groups: control group, low-dose (300 mg/kg) high-dose (600 fucoidan-treatment groups. After 5 weeks treatment, 10 per group selected be sacrificed after feces collection. The remaining 12 fed until 26 age assess incidence diabetes. Results Treatment with...
Both in Germany and China, there is strong expertise regarding the different aspects of forest management, as well products management. Nevertheless, forestry both countries facing challenges, some which are regional, but many shared. Therefore, experts from (Technical University Munich Germany; Northwest A&F Yangling, China; Forestry Academy Shaanxi, Thünen Institut, FEDRC GIZ Forest Policy Facility (Forestry Economics Development Research Center Deutsche Gesellschaft für Internationale...
Fate determination of germline stem cells remains poorly understood at the chromatin structure level.Our research hopes to develop successful offspring production ovarian organoids derived from spermatogonial (SSCs) by defined factors.The oocytes transdifferentiated mouse SSCs with tracking transplanted in vivo, single cell whole exome sequencing, and 3D culture reconstitution process oogenesis SSCs. The factors were screened organoids. We uncovered extensive reorganization during SSC...
As an ecological unit, coarse woody debris (CWD) plays essential role in productivity, nutrient cycling, carbon sequestration, community regeneration and biodiversity. However, thus far, the information on quantification decomposition content of CWD forest ecosystems remains considerably limited. In this study, we conducted a long-term (1996-2013) study decay dynamics for evaluating accurately value Huoditang Experimental Forest Farm Qinling Mountains, China. The results demonstrated that...