A5101605212- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Cell death mechanisms and regulation
- RNA Research and Splicing
- Fungal and yeast genetics research
- FOXO transcription factor regulation
- Chemotherapy-induced cardiotoxicity and mitigation
- Signaling Pathways in Disease
- Cellular transport and secretion
- Genomics and Chromatin Dynamics
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Soft tissue tumor case studies
- Galectins and Cancer Biology
- Health disparities and outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Telemedicine and Telehealth Implementation
- Extracellular vesicles in disease
- Telomeres, Telomerase, and Senescence
- Plant Gene Expression Analysis
Affiliated Hospital of Qingdao University
2015-2025
Qingdao University
2015-2025
University of Massachusetts Chan Medical School
2018
University of California, Davis
2017
University of Massachusetts Amherst
2015
The University of Texas Southwestern Medical Center
1997-2000
Southwestern Medical Center
2000
Non-coding RNAs (ncRNAs) are considered major players in physiological and pathological processes based on their versatile regulatory roles different diseases including cardiovascular disease. Circular (circRNAs), a newly discovered class of RNAs, constitute substantial fraction the mammalian transcriptome abundantly expressed system. However, functions these circRNAs ischemic cardiac disease remain largely unknown. Here, we investigated role circRNA transcribed from sodium/calcium exchanger...
Aims: Cardiomyocyte death critically contributes to the pathogenesis of cardiac disorders, such as myocardial infarction, heart failure, and ischemia/reperfusion (I/R) injury. As one main forms cell death, necrosis plays a critical role in diseases. Multiple signaling pathways have been demonstrated, which receptors, receptor-interacting serine/threonine-protein 1 3 kinases, cyclophilin-D (CypD) deeply implicated. However, fundamental mechanism underlying necroptosis, especially...
Necrosis is a key factor in myocardial injury during cardiac pathological processes, such as infarction (MI), ischemia/reperfusion (I/R) and heart failure. Increasing evidence suggests that several aspects of necrosis are programmed tightly regulated, so targeting the process has become new trend for protection. Multiple cellular signaling pathways have been implicated necrotic cell death, death receptor-mediated extrinsic mitochondrial intrinsic pathways. However, precise mechanisms...
BACKGROUND: Circular RNAs (circRNAs) have been gradually revealed to regulate the progression of heart disease in depth, showing their clinical significance. However, a mass cardiac circRNAs still has not functionally characterized. We aimed explore potential candidates that are involved pathological hypertrophy. METHODS: Public substantial RNA-sequencing data were utilized search hypertrophy–related circRNAs. Cardiomyocyte hypertrophy vitro was induced by Ang II (angiotensin II) treatment....
Abstract MicroRNA (miR)‐9 plays different roles in cancer types. Here, we investigated the role of miR‐9 non‐small‐cell lung ( NSCLC ) cell invasion and adhesion vitro explored whether was involved transforming growth factor‐beta 1 TGF ‐β1)‐induced by targeting SOX 7. The expression 7 human tissues lines examined reverse transcription‐quantitative polymerase chain reaction. Gain‐of‐function loss‐of‐function experiments were performed on A549 HCC 827 cells to investigate effect presence or...
Doxorubicin (DOX) is a broad-spectrum anti-tumor drug, but its cardiotoxicity limits clinical application. A better understanding of the molecular mechanisms underlying DOX will benefit practice and remedy heart failure. Our present study observed that caused cardiomyocyte (H9c2) apoptosis via induction abnormal mitochondrial fission. Notably, expression levels p21 increased in DOX-treated cardiomyocytes, silencing using siRNA greatly attenuated fission cardiomyocytes. We also found...
Cardiovascular disease is the major cause of death in patients with diabetes. Current treatment strategies for diabetes rely on lifestyle changes and glucose control to prevent angiopathy organ failure. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, used as an add-on therapy insulin treatment. Exenatide also has multiple beneficial effects addition its hypoglycemic effects, such preventing hepatic steatosis protecting against cardiac injury from doxorubicin-induced...
Synaptotagmins bind clathrin AP-2 with high affinity via their second C<sub>2</sub> domain, which indicates they are involved in coated pit function. We now report that expression of synaptotagmins lacking either the domain or entire cytoplasmic region potently inhibit endocytosis. Inhibition was dependent on two intramembrane cysteine residues were found to be essential for synaptotagmin oligomerization. Cells expressing wild-type, but not mutant, truncated fragment had a reduced number...
Iron overload is common in cardiovascular disease, it also the factor that drives ferroptosis. Noncoding RNAs play an important role heart disease; however, their regulatory iron overload-mediated ferroptosis remains much unknown. In our study, model mice was constructed through a high-iron diet, and ammonium citrate treatment used to mimic vitro. We found induced cardiomyocytes, which dependent on high expression of transferrin receptor (TFRC). MiR-31-5p downregulated during overload;...
The substantial epigenetic remodeling that occurs during early stages of mammalian embryonic development likely contributes to reprogramming the parental genomes from a differentiated totipotent state and activation genome. Trimethylation lysine 27 histone 3 (H3K27me3) is repressive mark undergoes global dynamic changes preimplantation several species. To ascertain role H3K27me3 in bovine we perturbed activity KDM6B, which demethylates H3K27me3. Knockdown maternal KDM6B mRNA inhibited...
S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production. SAM hypothesized to link metabolism chromatin modification, however, its role in acute gene regulation poorly understood. We recently found that Caenorhabditis elegans with reduced had deficiencies H3K4 trimethylation (H3K4me3) at pathogen-response genes, decreasing their expression limiting pathogen resistance. may be generally required...
Pre-B-cell leukemia transcription factor (PBX) proteins have important roles in the development of numerous organs. To date, four members PBX family been identified to be involved human cancer but little is known about their expression patterns and precise functions breast (BC) progression. The aim present study was determine whether they potential prognostic biomarkers patients with BC. PBXs were evaluated using Oncomine, Cancer Cell Line Encyclopedia Gene expression‑based Outcome for...