A5059212207- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS drug development and treatment
- Gut microbiota and health
- Sex work and related issues
- Hepatitis C virus research
- HIV-related health complications and treatments
- Antifungal resistance and susceptibility
- Data-Driven Disease Surveillance
- Genital Health and Disease
- Fungal Infections and Studies
- Female Genital Mutilation/Cutting Issues
- Autophagy in Disease and Therapy
- Urologic and reproductive health conditions
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Syphilis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Tryptophan and brain disorders
- Hepatitis B Virus Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Grey System Theory Applications
Guangxi Medical University
2016-2025
Guangxi Center for Disease Prevention and Control
2022-2025
Guangxi University
2023-2024
Chinese University of Hong Kong
2023
Hepatitis is a serious public health problem with increasing cases and property damage in Heng County. It necessary to develop model predict the hepatitis epidemic that could be useful for preventing this disease.The autoregressive integrated moving average (ARIMA) generalized regression neural network (GRNN) were used fit incidence data from County CDC (Center Disease Control Prevention) January 2005 December 2012. Then, ARIMA-GRNN hybrid was developed. The 2013 validate models. Several...
Background Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic worldwide, and gut microbes are associated with development progression NAFLD. Despite numerous studies exploring changes in NAFLD, there was no consistent pattern changes. Method We retrieved on human fecal microbiota sequenced by 16S rRNA gene amplification NAFLD from NCBI database up to April 2023, re-analyzed them using bioinformatic methods. Results finally screened 12 relevant related which...
The HIV/AIDS data from the national surveillance systems of China and United States 1985 to 2014 were compared characterize epidemic in both countries. current estimated HIV prevalence rate are 0.0598% 0.348%, respectively. In States, annual number new infections has remained relatively stable (~50,000 each year) shown a downward trend recent years. Chinese is still low, have been contained at low level (50,000–100,000 year). However, showed an increasing since 2012. By risk group,...
This study aimed to investigate the prevalence of HIV late presentation and advanced disease identify factors associated with among patients newly diagnosed HIV/AIDS in Guangxi Zhuang Autonomous Region, Southwestern China.Patients registered surveillance system Centers for Disease Control between January 2012 December 2016 were included this study.Of 45,118 patients, 70.2% had presentation, 45.1% disease. A higher was found male heterosexuals female people who use drugs (PWID). Heterosexuals...
Guangxi, a province in southwestern China, has the second highest reported number of HIV/AIDS cases China. This study aimed to develop an accurate and effective model describe tendency HIV predict its incidence Guangxi. data Guangxi from 2005 2016 were obtained database Chinese Center for Disease Control Prevention. Long short-term memory (LSTM) neural network models, autoregressive integrated moving average (ARIMA) generalised regression (GRNN) models exponential smoothing (ES) used fit...
Background New evidence implies that the imbalance of gut microbiota is associated with progression alcoholic liver disease (ALD) and composition altered in ALD patients. However, predominant bacterium patients involved progress has not been identified. The purpose this study to investigate early end-stages as well relationship between degree injury. Methods We enrolled 21 fatty (AFL) patients, 17 cirrhosis (ALC) 27 healthy controls, sequenced 16S rRNA gene their fecal microbiota. its...
Objective Talaromycosis is a serious regional disease endemic in Southeast Asia. In China, Talaromyces marneffei (T. marneffei) infections mainly concentrated the southern region, especially Guangxi, and cause considerable in-hospital mortality HIV-infected individuals. Currently, factors that influence death of HIV/AIDS patients with T . infection are not completely clear. Existing machine learning techniques can be used to develop predictive model identify relevant prognostic predict...
Background The immune activation caused by microbial translocation has been considered to be a major driver of HIV infection progression. dysbiosis gut microbiota demonstrated in infection, but the interplay between and its metabolites pathogenesis is seldom reported. Methods We conducted case-controlled study including 41 AIDS patients, 39 pre-AIDS patients 34 healthy controls. Both group were divided according clinical manifestations CD4 + T cell count. collected stool samples for 16S rDNA...
Acceptability of pre-exposure prophylaxis (PrEP) and willingness to participate in a clinical trial for both safety efficacy PrEP were investigated among female sex workers (FSWs) Guangxi, China.
Gut microbiota is the largest population of microorganisms and closely related to health. Many studies have explored changes in gut viral hepatitis. However, correlation between occurrence progression hepatitis has not been fully clarified.PubMed BioProject databases were searched for about disease 16S rRNA gene sequencing up January 2023. With bioinformatics analyses, we microbial diversity hepatitis, screened out crucial bacteria functions identified potential markers predicting risks...
Teleoperation is a critical method for human-robot interface, holds significant potential enabling robotic applications in industrial and unstructured environments. Existing teleoperation methods have distinct strengths limitations flexibility, range of workspace precision. To fuse these advantages, we introduce the Global-Local (G-L) Interface. This interface decouples into global behavior, which ensures robot motion intuitiveness, local enhances human operator's dexterity capability...
To assess the impact of anemia severity during antiretroviral therapy (ART) on in-hospital mortality among persons living with HIV. We conducted a retrospective cohort study hospitalized HIV at Fourth People's Hospital Nanning, Guangxi, China, from 2018 to 2020. Kaplan-Meier analysis was used calculate cumulative rates. The Cox proportional hazards model, 1:1:1 propensity score matching (PSM), and three-group inverse probability treatment weighting (IPTW) were in A total 2,217 included, whom...
Hepatitis C virus (HCV) has become a serious global public health issue. Existing study confirmed the potential role of internet search data in prediction infectious diseases. This aims to explore predictive models suitable for HCV, providing references and recommendations actively responding World Health Organization's strategy eliminate HCV by 2030. We collected publicly available daily reported case numbers volume HCV-related keywords Baidu Search Index (BSI) from January 2011 September...
Objective To characterise the association between duration of exposure to antiretroviral treatment (ART) and liver damage in HIV patients with an initially normal baseline function without hepatitis B virus (HBV)/hepatitis C (HCV) infection. Methods A retrospective cohort study was conducted HIV-infected individuals parameters at ART initiation HBV/HCV infection, from 14 April 2004 13 2015 Guigang city, Guangxi, China. The (grade II–IV enzyme elevation [LEE] and/or total bilirubin [TBE]),...
Little is known about how Talaromyces marneffei, a thermally dimorphic fungus that causes substantial morbidity and mortality in Southeast Asia, evades the human immune system. Polarization of macrophages into fungal-inhibiting M1-like fungal-promoting M2-like types has been shown to play an important role innate response against fungal pathogens. This mechanism not defined for T. marneffei. Here, we demonstrated marneffei promotes its survival by inducing them toward polarization. Our...
Internet-derived data and the autoregressive integrated moving average (ARIMA) ARIMA with explanatory variable (ARIMAX) models are extensively used for infectious disease surveillance. However, effectiveness of Baidu search index (BSI) in predicting incidence scarlet fever remains uncertain.Our objective was to investigate whether a low-cost BSI monitoring system could potentially function as valuable complement traditional surveillance China.ARIMA ARIMAX were developed predict China using...
Introduction. Increasing evidence suggests a correlation between gut microbiota and colorectal cancer (CRC).Hypothesis/Gap Statement. However, few studies have used as diagnostic biomarker for CRC.Aim. The objective of this study was to explore whether machine learning (ML) model based on could be diagnose CRC identify key biomarkers in the model.Methodology. We sequenced 16S rRNA gene from faecal samples 38 participants, including 17 healthy subjects 21 patients. Eight supervised ML...
Previous studies have shown that mycophenolic acid (MPA) has an anti-HCV activity. However, the mechanism of MPA-mediated inhibition HCV replication remains to be determined. This study investigated whether MPA effect on autophagy, a cellular machinery required for replication, thereby, inhibits in Huh7 cells. treatment cells could suppress evidenced by decreased LC3B-II level and conversion LC3B-I LC3B-II, autophagosome formation, increased p62 compared MPA-untreated Tunicamycin or...